Studies on the Nature and Genetic Control of an Antigen in Normal Chick Embryos which Reacts in the COFAL Test (original) (raw)

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Abstract

Summary

Chick embryos from the inbred Reaseheath I line of chickens contained a complement-fixing antigen which reacted in the COFAL test, whereas embryos from the inbred Reaseheath C line lacked the antigen. In cross-bred embryos between the I and C lines the antigen segregated in accordance with the hypothesis that the presence of the antigen was controlled by a single autosomal dominant gene. The antigen appeared to be identical to the group-specific antigen of the avian leukosis-sarcoma group of viruses. No infectious virus was detected in I-line embryos, and the presence of the antigen was not correlated with response to the A and B subgroups of avian leukosis-sarcoma viruses. The possible relationship between the I-line antigen and viral group-specific antigen is discussed.

• Received: 18/03/1968
• Accepted:20/05/1968
• Published Online:01/12/1968

© Journal of General Virology 1968

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1968-12-01

2024-10-23

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