Shedding and Interspecies Type Sero-reactivity of the Envelope Glycopolypeptide gp120 of the Human Immunodeficiency Virus (original) (raw)
Abstract
Summary
Two glycopolypeptides with molecular weights 160000 and 120000 (gp120) are regularly recognized by human immunodeficiency virus (HIV)-specific antisera in lysates of cells persistently infected with HIV. In the present study, gp120 was characterized as the major envelope glycopolypeptide of HIV. Gp120 was identified as the external viral glycoprotein by radiosequencing and by its presence in purified virus. However gp120 was predominantly shed as a soluble protein into the culture fluid. Furthermore gp120 was precipitated by sera from horses infected with equine infectious anaemia virus (EIAV), but not by sera from uninfected animals. This may indicate conserved epitopes common to the envelopes of HIV and EIAV.
- Received: 26/07/1986
- Accepted:29/07/1986
- Published Online:01/11/1986
© The Journal of General Virology 1986
Article metrics loading...
/content/journal/jgv/10.1099/0022-1317-67-11-2533
1986-11-01
2024-10-23
Full text loading...
/deliver/fulltext/jgv/67/11/JV0670112533.html?itemId=/content/journal/jgv/10.1099/0022-1317-67-11-2533&mimeType=html&fmt=ahah
Most read this month
Article
content/journal/jgv
Journal
5
3
false
en