cDNA clones of Japanese hepatitis C virus genomes derived from a single patient show sequence heterogeneity (original) (raw)

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Abstract

Twelve cDNA clones of Japanese hepatitis C virus (HCV) have been isolated from liver tissue of a single non-A, non-B hepatitis patient. These clones represented the non-structural domains of HCV. The degree of substitution in the nucleotide sequences and deduced amino acid sequences between these clones was 9.5 and 7.7%, respectively. This high level of substitution suggested that repeated infections of different HCVs may have occurred in the patient.

• Received: 03/04/1991
• Accepted:31/07/1991
• Published Online:01/11/1991

© Journal of General Virology 1991

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/content/journal/jgv/10.1099/0022-1317-72-11-2805

1991-11-01

2025-01-23

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