Sustained G→A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome (original) (raw)

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Abstract

Two full-length human immunodeficiency virus type 1 O sequences are described, one of which was hypermutated in all regions of the genome. This indicates that the intracellular [dTTP]/[dCTP] bias conducive to G→A hypermutation may be sustained throughout the synthesis of minus-strand DNA. In turn, this suggests the possibility of mutation of host sequences.

• Received: 09/10/2001
• Accepted:26/11/2001
• Published Online:01/04/2002

© Microbiology Society

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2002-04-01

2024-10-24

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