The Intracellular Forms of T7 and P22 DNA Molecules (original) (raw)

1. C. A. Thomas, Jr.,
2. T. J. Kelly, Jr.*, and
3. Marc Rhoades†
4. Department of Biological Chemistry, Harvard Medical School, Boston, Massachusetts * John Hopkins University School of Medicine, Baltimore, Maryland † Biological Laboratories, Harvard University, Cambridge, Massachusetts

Excerpt

The final products of viral DNA replication are mature viral chromosomes. Any consideration of the intracellular replicating forms of viral DNA molecules should take proper account of the structure of the final product. Therefore, this paper will begin with a brief review of what is now known about the structure of mature viral DNA molecules. From this it will be clear why we have studied the intracellular forms of T7 and P22.

THE COMPARATIVE ANATOMY OF VIRAL DNA MOLECULES

Figure 1 summarizes what is known about the structures of the mature phage DNA molecules that have been studied to date. Leaving aside the [Graphics Excised] single-chain-containing small phage such as ϕx or fd, the known larger phage DNA molecules are linear duplexes that differ from each other in the following ways: (1) the presence or absence...