A Biochemical and Genetic Analysis of Mammalian RNA-containing Sarcoma Viruses (original) (raw)

1. E. M. Scolnick,
2. R. J. Goldberg, and
3. W. P. Parks
4. National Cancer Institute, Bethesda, Maryland 20014

Excerpt

RNA-containing type C viruses have been classified into two groups based on the biological properties of the viruses. One group consists of leukemia-producing viruses, which are able to cause a variety of lymphoproliferative diseases in their natural hosts (Huebner and Todaro 1969) but generally infect fibroblast cell cultures without morphologically transforming the cells. In this paper we will refer to such type C viruses as fibroblast transforming negative (FT−). The other group consists of sarcoma-producing viruses, which cause sarcomas in animals and when grown in cell cultures produce morphologic transformation of fibroblasts (FT+). Leukemia-producing viruses have frequently been isolated from many different phyla. On the other hand, isolates of sarcoma-producing viruses have been more limited. Although the number of isolates of sarcoma-producing virus has been more limited, such viruses have been isolated from diverse phyla, including aves (Rous 1911) and mammals, and within the mammalian phylum from mice (Moloney 1966),...