Nuclear Stress Bodies (original) (raw)

  1. Claire Vourc’h2
  2. 1Istituto di Genetica Molecolare. CNR; Via Abbiategrasso 207. 27100 Pavia, Italy
  3. 2Université Joseph Fourier; INSERM; Institut Albert Bonniot U823, La Tronche BP170, 38042 Grenoble cedex 9, France
  4. Correspondence: biamonti{at}igm.cnr.it and claire.vourch{at}ujf-grenoble.fr

Abstract

Nuclear stress bodies (nSBs) are unique subnuclear organelles which form in response to heat shock. They are initiated through a direct interaction between heat shock transcription factor 1 (HSF1) and pericentric tandem repeats of satellite III sequences and correspond to active transcription sites for noncoding satellite III transcripts. Given their unusual features, nSBs are distinct from other known transcription sites. In stressed cells, they are thought to participate in rapid, transient, and global reprogramming of gene expression through different types of mechanisms including chromatin remodeling and trapping of transcription and splicing factors. The analysis of these atypical and intriguing structures uncovers new facets of the relationship between nuclear organization and nuclear function.

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