Cooperative regulation in development by SMRT and FOXP1 (original) (raw)

  1. Kristen Jepsen1,5,
  2. Anatoli S. Gleiberman2,
  3. Can Shi3,
  4. Daniel I. Simon3, and
  5. Michael G. Rosenfeld1,4
  6. 1 Department of Medicine, Howard Hughes Medical Institute, University of California at San Diego, School of Medicine, La Jolla, California 92093, USA;
  7. 2 Cleveland Biolabs, Inc., Buffalo, New York 14052, USA;
  8. 3 University Hospitals Case Medical Center, Case Western Reserve University School of Medicine. Cleveland, Ohio 44106, USA

Abstract

A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination events. While the role of NCoR/SMRT corepressors in nuclear receptor actions is well documented, we here report that a previously unrecognized functional interaction between SMRT and a forkhead protein, FOXP1, is required for cardiac growth and regulation of macrophage differentiation. Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor.

Footnotes