Anterior cingulate cortex in schema assimilation and expression (original) (raw)

1. Dorothy Tse and
2. Richard G.M. Morris
3. Centre for Cognitive and Neural Systems, The University of Edinburgh, EH8 9JZ Edinburgh, United Kingdom

Abstract

In humans and in animals, mental schemas can store information within an associative framework that enables rapid and efficient assimilation of new information. Using a hippocampal-dependent paired-associate task, we now report that the anterior cingulate cortex is part of a neocortical network of schema storage with NMDA receptor-mediated transmission critical for information updating, and AMPA receptor-mediated transmission required for the expression and updating of stored information.

Footnotes

• ↵1 Corresponding author
  E-mail s.wang{at}ed.ac.uk

• [Supplemental material is available for this article.]

• Received March 9, 2012.

• Accepted May 30, 2012.

• © 2012 Cold Spring Harbor Laboratory Press

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