Mechanisms of Viral Activators (original) (raw)

1. A.J. BERK,
2. T.G. BOYER,
3. A.N. KAPANIDIS,
4. R.H. EBRIGHT,
5. N.N. KOBAYASHI,
6. P.J. HORN,
7. S.M. SULLIVAN,
8. R. KOOP,
9. M.A. SURBY, and
10. S.J. TRIEZENBERG
11. *Molecular Biology Institute, University of California, Los Angeles, California 90095-1570; †Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry, Rutgers University, Piscataway, New Jersey 08854-8020; ‡Department of Biochemistry, Michigan State University, East Lansing, Michigan 48824-1319

Excerpt

Viral regulatory proteins were among the first eukaryotic transcriptional activators identified (Berk et al. 1979;Jones and Shenk 1979; Post et al. 1981; Campbell et al.1984). They generally induce a very high rate of viralgene transcription and thus are excellent models for analyzing mechanisms of transcriptional activation. Ourstudies have focused primarily on the adenovirus largeE1A, Epstein-Barr virus Zebra, and herpes simplex virusVP16 proteins...