Control of Lymphocyte Differentiation by the LEF-1/TCF Family of Transcription Factors (original) (raw)

1. T. REYA,
2. R. OKAMURA, and
3. R. GROSSCHEDL
4. Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, California 94143-0414

Excerpt

Lymphocyte differentiation is a complex process thatallows stem cells to develop into highly specialized cells.The external signals that regulate cell-lineage and stagespecific expression of genes include extracellular growthfactors and cell–cell contact. Within a given cell, thesecues are integrated by transcription factors that play a particularly important role in executing a program of differentiation (for review, see Clevers and Ferrier 1998; Reyaand Grosschedl 1998)...