Exploiting the bad eating habits of Ras-driven cancers (original) (raw)

1. Eileen White1
2. Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA

Abstract

Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.

• Ras
• macropinocytosis
• autophagy
• cancer metabolism
• glutamine
• scavenging

Footnotes

• ↵1 Correspondence
  E-mail eileenpwhite{at}gmail.com and epwhite{at}cinj.rutgers.edu

• Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.228122.113.

• © 2013 White; Published by Cold Spring Harbor Laboratory Press

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