Differential involvement of dopamine D1 receptor and MEK signaling pathway in the ventromedial prefrontal cortex in consolidation and reconsolidation of recognition memory (original) (raw)
- Mouna Maroun1 and
- Irit Akirav2,3
- 1Department of Neurobiology and Ethology, University of Haifa, Haifa 31905, Israel;
- 2Department of Psychology, University of Haifa, Haifa 31905, Israel
Abstract
We investigated MEK and D1 receptors in the ventromedial prefrontal cortex (vmPFC) in consolidation and reconsolidation of recognition memory in rats nonhabituated to the experimental context (NH) or with reduced arousal due to extensive prior habituation (H). The D1 receptor antagonist enhanced consolidation and impaired reconsolidation in NH but impaired consolidation with no effect on reconsolidation in H. The D1 receptor agonist had no effect on consolidation in either H or NH but impaired reconsolidation in both groups. The MEK inhibitor impaired consolidation and reconsolidation, regardless of arousal. Thus, vmPFC D1 receptors and MEK show differential involvement in memory and arousal.
Footnotes
↵3 Corresponding author.
↵E-mail irit.akirav{at}gmail.com or iakirav{at}psy.haifa.ac.il; fax 972-4-8288268.Article is online at http://www.learnmem.org/cgi/doi/10.1101/lm.1245009.
- Received September 28, 2008.
- Accepted January 20, 2009.
Copyright © 2009 by Cold Spring Harbor Laboratory Press