RNA Polymerase-DNA Interaction: Structures of Intermediate, Open, and Elongation Complexes (original) (raw)

1. R.H. EBRIGHT
2. Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry, Rutgers University, Piscataway, New Jersey 08854

Excerpt

RNA polymerase (RNAP) is the enzyme responsiblefor the first step in gene expression and is the target, directly or indirectly, of most regulation of gene expression. Understanding RNAP structure and function is essential for understanding gene expression and regulationof gene expression and, as such, is a fundamental objective of structural biolog...