- Ahola H, Heikkila E, Astrom E (2003) A novel protein, densin, expressed by glomerular podocytes. J Am Soc Nephrol 14, 1731–7.
Article PubMed CAS Google Scholar
- Andrews PM (1977) The effect of vinblastine-induced microtu-bule loss on kidney podocyte morphology. Am J Anat 150, 53–61.
Article PubMed CAS Google Scholar
- Apperson ML, Moon IS, Kennedy MB (1996) Characterization of densin-180, a new brain-specific synaptic protein of the _O_-sialoglycoprotein family. J Neurosci 16, 6839–952.
PubMed CAS Google Scholar
- Balda MS, Matter K (2003) Epithelial call adhesion and the regulation of gene expression. Tr ends Cell Biol 13, 310–18.
CAS Google Scholar
- Barisoni L, Kopp JB (2003) Update in podocyte biology: Putting one’s best foot forward. Curr Opin Nephrol Hypertens 12, 251–9.
Article PubMed CAS Google Scholar
- Barisoni L, Mundel P (2003) Podocyte biology and the emerging understanding of podocyte diseases. Am J Nephrol 23, 353–60.
Article PubMed Google Scholar
- Barletta GM, Kovari IA, Verma RK, Kerjaschki D, Holzman LB (2003) Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J Biol Chem 278, 19 266–71.
Google Scholar
- Beltcheva O, Kontusaari S, Fetissov S et al. (2003) Alternatively used promoters and distinct elements direct tissue-specific expression of nephrin. J Am Soc Nephrol 14, 352–8.
Article PubMed CAS Google Scholar
- Beltran PJ, Bixby JL, Masters BA (2003) Expression of PTPRO during mouse development suggests involvement in axono-genesis and differentiation of NT-3 and NGF-dependent neurons. J Comp Neurol 465, 384–95.
Article Google Scholar
- Bourdoulous S, Bourdoulous S, Orend G, MacKenna DA, Pas-qualini R, Ruoslahti E (1998) Fibronectin matrix regulates activation of RHO and CDC42 GTPases and cell cycle progression. J Cell Biol 143, 267–76.
Article PubMed CAS Google Scholar
- Chiou JY, Westhead EW (1992) Okadaic acid, a protein phosphatase inhibitor, inhibits nerve growth factor-directed neurite outgrowth in PC12 cells. J Neurochem 59, 1963–6.
Article PubMed CAS Google Scholar
- Cortes P, Mendez M, Riser BL et al. (2000) F-Actin fiber distribution in glomerular cells: Structural and functional implications. Kidney Int 58, 2452–61.
Article PubMed CAS Google Scholar
- de Hoop MJ, Dotti CG (1993) Membrane traffic in polarized neurons in culture. J Cell Sci Suppl 17, 85–92.
PubMed Google Scholar
- Deller T, Mundel P (2000) Potential role of synaptopodin in spine motility by coupling actin to the spine apparatus. Hippocampus 10, 569–81.
Article PubMed CAS Google Scholar
- Dong JM, Leung T, Manser E, Lim L (1998) cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKalpha. J Biol Chem 273, 22 554–62.
Google Scholar
- Dotti CG, Simons K (1990) Polarized sorting of viral glycopro-teins to the axon and dendrites of hippocampal neurons in culture. Cell 62, 63–72.
Article PubMed CAS Google Scholar
- Endlich K, Kriz W, Witzgall R (2001) Update in podocyte biology. Curr Opin Nephrol Hypertens 10, 331–40.
Article PubMed CAS Google Scholar
- Feoktistov I, Goldstein AE, Biaggioni I (2000) Cyclic AMP and protein kinase A stimulate Cdc42: Role of A(2) adenosine receptors in human mast cells. Mol Pharmacol 58, 903–10.
PubMed CAS Google Scholar
- Gao FB, Brenman JE, Jan LY, Jan YN (1999) Genes regulating dendritic outgrowth, branching, and routing in Drosophila. Gene Dev 13, 2549–61.
Article PubMed CAS Google Scholar
- Gao S, Li C, Chen J et al. (2004) Rho-ROCK signal pathway regulates microtubule-based process formation of cultured podocytes: Inhibition of ROCK promoted process elongation. Nephron Exp Nephrol (in press).
- Gerke P, Huber TB, Sellin L, Benzing T, Walz G (2003) Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1. J Am Soc Nephrol 14, 918–26.
Article PubMed CAS Google Scholar
- Gloy J, Reitinger S, Fischer KG et al. (2000) Amino acid transporter in podocytes. Am J Physiol 278, F999–1005.
Google Scholar
- Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K (2000a) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. J Biol Chem 275, 5535–44.
Article PubMed CAS Google Scholar
- Gong CX, Wegiel J, Lidsky T et al. (2000b) Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Res 853, 299–309.
Article PubMed CAS Google Scholar
- Goto H, Wakui H, Komatsuda A et al. (2003) Renal alpha-actinin-4: Purification and puromycin aminonucleoside-binding property. Nephron Exp Nephrol 93, E27–35.
Article Google Scholar
- Hara M, Ichida F, Higuchi A, Tanizawa T, Okada T (1984) Nephropathy associated with Charcot-Marie-Tooth disease. Int J Pediatr Nephrol 5, 99–102.
PubMed CAS Google Scholar
- Henderson BR, Fagotto F (2002) The ins and outs of APC and beta-catenin nuclear transport. EMBO Rep 3, 834–9.
Article PubMed CAS Google Scholar
- Hiraga A, Tamura S (2000) Protein phosphatase 2A is associated in an inactive state with microtubules through 2A1-specific interaction with tubulin. Biochem J 346, 433–9.
Article PubMed CAS Google Scholar
- Hirose M, Ishizaki T, Watanabe N et al. (1998) Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblast-oma N1E-115 cells. J Cell Biol 141, 1625–36.
Article PubMed CAS Google Scholar
- Huber TB, Schmidts M, Gerke P et al. (2003) The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem 278, 13 417–21.
Google Scholar
- Ichimura K, Kurihara H, Sakai T (2003) Actin filament organization of foot processes in rat podocytes. J Histochem Cytochem 51, 1589–600.
PubMed CAS Google Scholar
- Ihalmo P, Palmen T, Ahola H, Valtonen E, Holthofer H (2003) Filtrin is a novel member of nephrin-like proteins. Biochem Biophys Res Commun 300, 364–70.
Article PubMed CAS Google Scholar
- Inoue T, Yaoita E, Kurihara H et al. (2001) FAT is a component of glomerular slit diaphragms. Kidney Int 59, 1003–12.
Article PubMed CAS Google Scholar
- Jan Y, Jan LY (2003) The control of dendrite development. Neuron 40, 229–42.
Article PubMed CAS Google Scholar
- Kaplan JM, Kim SH, North KN et al. (2000) Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24, 251–6.
Article PubMed CAS Google Scholar
- Kato M, Sasaki T, Ohya T et al. (1996) Physical and functional interaction of rabphilin-3a with alpha-actinin. J Biol Chem 271, 31 775–8.
Google Scholar
- Kim K, Sirota A, Chen YH et al. (2002) Dendrite-like process formation and cytoskeletal remodeling regulated by delta-catenin expression. Exp Cell Res 275, 171–84.
Article PubMed CAS Google Scholar
- Kobayashi N (2002) Mechanism of the process formation: Podocytes versus neurons. Microsc Res Tech 57, 217–23.
Article PubMed CAS Google Scholar
- Kobayashi N, Mundel P (1998) A role of microtubules during the formation of cell processes in neuronal and non-neuronal cells. Cell Tissue Res 291, 163–74.
Article PubMed CAS Google Scholar
- Kobayashi N, Reiser J, Kriz W, Kuriyama R, Mundel P (1998) Non-uniform microtubular polarity, established by CHO1/ MKLP1 motor protein, is necessary for process formation of podocytes. J Cell Biol 143, 1961–70.
Article PubMed CAS Google Scholar
- Kobayashi N, Heid HW, Sakai T, Kriz W, Huber G, Mundel P (2000) Molecular characterization reveals the identity of microtubule-associated proteins MAP3 and MAP4. Biochem Biophys Res Commun 268, 306–9.
Article PubMed CAS Google Scholar
- Kobayashi N, Mominoki K, Wakisaka H, Shimazaki Y, Matsuda S (2001a) Morphogenetic activity of extracellular matrices on cultured podocytes. Ital J Anat Embryol 106 (Suppl. 1), 423–30.
PubMed CAS Google Scholar
- Kobayashi N, Reiser J, Schwarz K, Sakai T, Kriz W, Mundel P (2001b) Process formation of podocytes: Morphogenetic activity of microtubules and regulation by serine/threonine protein phosphatase PP2A. Histochem Cell Biol 115, 255–66.
PubMed CAS Google Scholar
- Kos CH, Le TC, Sinha S et al. (2003) Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest 111, 1683–90.
PubMed CAS Google Scholar
- Kreidberg JA (2003) Podocyte differentiation and glomerulo-genesis. J Am Soc Nephol 14, 806–14.
Article Google Scholar
- Kreidberg JA, Donovan MJ, Goldstein SL et al. (1996) Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis. Development 122, 3537–47.
PubMed CAS Google Scholar
- Kretzler M (2002) Regulation of adhesive interaction between podocytes and glomerular basement membrane. Microsc Res Tech 57, 247–53.
Article PubMed CAS Google Scholar
- Kriz W (2002) Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech 57, 189–95.
Article PubMed Google Scholar
- Kriz W, Kobayashi N, Elger M (1998) New aspects of podocyte structure, function and pathology. Clin Exp Nephrol 2, 85–99.
Article Google Scholar
- Lemieux G, Neemeh JA (1967) Charcot-Marie-Tooth disease and nephritis. Can Med Assoc J 97, 1193–8.
PubMed CAS Google Scholar
- Martinez MC, Ochiishi T, Majewski M, Kosik KS (2003) Dual regulation of neuronal morphogenesis by a delta-catenin- cortactin complex and Rho. J Cell Biol 162, 99–111.
Article PubMed CAS Google Scholar
- Mundel P, Shankland SJ (2002) Podocyte biology and responce to injury. J Am Soc Nephrol 13, 3005–15.
Article PubMed Google Scholar
- Mundel P, Reiser J, Zuniga Mejia Borja A et al. (1997a) Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 36, 248–58.
Article Google Scholar
- Mundel P, Heid HW, Mundel TM, Kruger M, Reiser J, Kriz W (1997b) Synaptopodin, an actin-associated protein in telen-cephalic dendrites and in renal podocytes. J Cell Biol 139, 193–204.
Article PubMed CAS Google Scholar
- Nakayama AY, Harms MB, Luo L (2000) Small GTPases Rac and Rho in the maintenance of dendritic spines and branches in hippocampal pyramidal neurons. J Neurosci 20, 5329–38.
PubMed CAS Google Scholar
- Neumann H, Schweigreiter R, Yamashita T, Rosenkranz K, Wekerle H, Barde YA (2002) Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism. J Neurosci 22, 854–62.
PubMed CAS Google Scholar
- Noren NK, Liu BP, Burridge K, Kreft B (2000) p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol 150, 567–80.
Article PubMed CAS Google Scholar
- Orlando RA, Takeda T, Zak B et al. (2001) The glomerular epithelial cell anti-adhesin podocalyxin associates with the actin cytoskeleton through interactions with ezrin. J Am Soc Nephrol 12, 1589–98.
PubMed CAS Google Scholar
- Patrie KM, Drescher AJ, Goyal M, Wiggins RC, Margolis B (2001) The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. J Am Soc Nephrol 12, 667–77.
PubMed CAS Google Scholar
- Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B (2002) Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. J Biol Chem 277, 30 183–90.
Google Scholar
- Pavenstaedt H, Kriz W, Kreztler M (2003) Cell biology of the glomerular podocyte. Physiol Rev 83, 253–307.
Google Scholar
- Peitsch WK, Hofmann I, Endlich N et al. (2003) Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. J Am Soc Nephrol 14, 1452–63.
Article PubMed Google Scholar
- Price NE, Wadzinski B, Mumby MC (1999) An anchoring factor targets protein phosphatase 2A to brain microtubules. Brain Res Mol Brain Res 73, 68–77.
Article PubMed CAS Google Scholar
- Quaggin S (2002) Transcriptional regulation of podocyte specification and differentiation. Microsc Res Tech 57, 208–11.
Article PubMed CAS Google Scholar
- Rastaldi MP, Armelloni S, Berra S et al. (2003) Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector Rabphilin-3a. Am J Pathol 163, 889–99.
PubMed CAS Google Scholar
- Redmond L, Ghosh A (2001) The role of Notch and Rho GTPase signaling in the control of dendritic development. Curr Opin Neurobiol 11, 111–17.
Article PubMed CAS Google Scholar
- Reiser J, Kriz W, Kretzler M, Mundel P (2000) The glomerular slit diaphragm is a modified adherens junction. J Am Soc Nephrol 11, 1–8.
PubMed CAS Google Scholar
- Rodriguez OC, Schaefer AW, Mandato CA, Forscher P, Bement WM, Waterman-Storer CM (2003) Conserved microtubule- actin interactions in cell movement and morphogenesis. Nature Cell Biol 5, 599–609.
Article PubMed CAS Google Scholar
- Sakai T, Kriz W (1987) The structural relationship between mesangial cells and basement membrane of the renal glomerulus. Anat Embryol 176, 373–86.
Article PubMed CAS Google Scholar
- Saleem MA, Ni L, Witherden I et al. (2002) Co-localization of nephrin, podocin, and the actin cytoskeleton: Evidence for a role in podocyte foot process formation. Am J Pathol 161, 1459–66.
PubMed CAS Google Scholar
- Schmid H, Henger A, Cohen CD et al. (2003) Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases. J Am Soc Nephrol 14, 2958–66.
Article PubMed CAS Google Scholar
- Schwarz K, Simons M, Reiser J et al. (2001) Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 108, 1621–9.
PubMed CAS Google Scholar
- Scott EK, Reuter JE, Luo L (2003) Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci 23, 3118–23.
PubMed CAS Google Scholar
- Sellin L, Huber TB, Gerke P, Quack I, Pavenstadt H, Walz G (2003) NEPH1 defines a novel family of podocin-interacting proteins. FASEB J 17, 115–17.
PubMed CAS Google Scholar
- Shirato I, Sakai T, Kimura K, Tomino Y, Kriz W (1996) Cytoskel-etal changes in podocytes associated with foot process effacement in Masugi nephritis. Am J Pathol 148, 1283–96.
PubMed CAS Google Scholar
- Simons M, Saffrich R, Reiser J, Mundel P (1999) Directed membrane transport is involved in process formation of cultured podocytes. J Am Soc Nephrol 10, 1633–9.
PubMed CAS Google Scholar
- Somlo S, Mundel P (2000) Getting a foothold in nephrotic syndrome. Nat Genet 24, 333–5.
Article PubMed CAS Google Scholar
- Sontag E, Nunbhakdi-Craig V, Lee G et al. (1999) Molecular interactions among protein phosphatase 2A, tau, and micro-tubules. J Biol Chem 274, 25 490–8.
Google Scholar
- Takai Y, Sasaki T, Matozaki T (2001) Small GTP-bindings proteins. Physiol Rev 81, 153–207.
PubMed CAS Google Scholar
- Takeda T, McQuistan T, Orlando RA, Farquhar MG (2001) Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest 108, 289–301.
PubMed CAS Google Scholar
- Togawa A, Miyoshi J, Ishizaki H et al. (1999) Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene 18, 5373–80.
Article PubMed CAS Google Scholar
- Usui J, Kurihara H, Shu Y et al. (2003) Localization of intercellular adherens junction protein p120 catenin during podocyte differentiation. Anat Embryol 206, 175–84.
PubMed CAS Google Scholar
- Wong WT, Faulkner-Jones BE, Sanes JR, Wong RO (2000) Rapid dendritic remodeling in the developing retina: Dependence on neurotransmission and reciprocal regulation by Rac and Rho. J Neurosci 20, 5024–36.
PubMed CAS Google Scholar
- Yamaguchi Y, Katoh H, Yasui H, Mori K, Negishi M (2001) RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. J Biol Chem 276, 18 977–83.
Google Scholar
- Yu W, Sharp DJ, Kuriyama R, Mallik P, Baas PW (1997) Inhibition of a mitotic motor compromises the formation of dendrite-like processes from neuroblastoma cells. J Cell Biol 136, 659–68.
Article PubMed CAS Google Scholar
- Yu W, Cook C, Sauter C, Kuriyama R, Kaplan PL, Baas PW (2000) Depletion of a microtubule-associated motor protein induces the loss of dendritic identity. J Neurosci 20, 5782–91.
PubMed CAS Google Scholar
- Yu X, Malenka RC (2003) Beta-catenin is critical for dendritic morphogenesis. Nat Neurosci 6, 1169–77.
Article PubMed CAS Google Scholar
- Yuan XB, Jin M, Xu X et al. (2003) Signalling and crosstalk of Rho GTPases in mediating axon guidance. Nat Cell Biol 5, 1–8.
Article CAS Google Scholar