The Roles of pH and Concentration in Lactic Acid-induced... : Dermatologic Surgery (original) (raw)

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The Roles of pH and Concentration in Lactic Acid-induced Stimulation of Epidermal Turnover

THUESON, DAVID O. PHD1; CHAN, ELAINE K. PHARMD1; OECHSLI, LAUREN M. BA1; HAHN, GARY S. MD1

1 Cosmederm Technologies, Inc. (DOT, EKC, IMO, GSH), La folk; and the Immunology & Allergy Division, Department of Pediatrics (GSH), University of California, San Diego, California.

Address correspondence and reprint requests to: Gary S. Hahn, MD, Cosmederm Technologies, 3252 Holiday Court, La Jolla, CA 92037.

Elaine K. Chan, PharmD is now at Lakeport Hospital, Lakeport, CA.

This work was supported by Cosmederm Technologies, Inc.

Abstract

background.

Alpha hydroxy acids such as lactic and glycolic acids (AHAs) accelerate epidermal turnover and exfoliate the stratum corneum. The roles of pH and concentration in these antiaging effects of AHAs is unclear, but a lower (more acidic) pH and higher concentration of acid are thought to be more effective.

objective.

To examine the effects on skin renewal rates of lactic acid 10% at pHs of 2.0, 3.0, and 4.0, and of 5%, 10% and 15% lactic acid at a pH of 3.0.

methods.

Twenty-six female subjects participated in this double-blind, randomized, placebo-controlled study. The dansylchloride stain technique was used to measure epidermal renewal times.

results.

Both pH and concentration are critical in the lactic acid effect. At a fixed lactic acid concentration, the desquamative effect was highly pH dependent. At a fixed pH, the turnover rate of skin was concentration dependent.

conclusion.

The desquamative and proliferation-stimulating effects of lactic acid are very pH and concentration dependent, suggesting the “free acid” concentration is the active moiety.