Great Apes and Zoonoses (original) (raw)
Comparing the origins of AIDS and malaria may provide insight for gauging the prospect of future pathogen transmissions from apes to humans.
Science
19 Apr 2013
Vol 340, Issue 6130
pp. 284-286
Abstract
Two of the most widespread and virulent diseases of modern humans appear to have originated in our closest relatives, the African apes. There is evidence that the parasite Plasmodium falciparum, the cause of malaria in humans, is of gorilla origin (1, 2), whereas the pandemic form of human immunodeficiency virus type 1 (HIV-1), the cause of acquired immune deficiency syndrome (AIDS), stems from a lentivirus infection of chimpanzees (3). Is their great ape origin a coincidence, or are there important parallels that could provide insight into the prospects of future zoonoses in which other pathogens from the great apes might successfully colonize humans?
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References
1
Liu W., et al., Nature 467, 420 (2010).
2
Ayouba A., et al., Int. J. Parasitol. 42, 709 (2012).
3
Keele B. F., et al., Science 313, 523 (2006).
4
Davies T. J., Pedersen A. B., Proc. Biol. Sci. 275, 1695 (2008).
5
Martin M. J., Rayner J. C., Gagneux P., Barnwell J. W., Varki A., Proc. Natl. Acad. Sci. U.S.A. 102, 12819 (2005).
6
Crosnier C., et al., Nature 480, 534 (2011).
7
Evans D. T., et al., Trends Microbiol. 18, 388 (2010).
8
Sharp P. M., Hahn B. H., Cold Spring Harb. Perspect. Med. 1, a006841 (2011).
9
Duval L., et al., Proc. Natl. Acad. Sci. U.S.A. 107, 10561 (2010).
10
Escalante A. A., et al., Proc. Natl. Acad. Sci. U.S.A. 102, 1980 (2005).
11
Carter R., Trends Parasitol. 19, 214 (2003).
12
Rayner J. C., Liu W., Peeters M., Sharp P. M., Hahn B. H., Trends Parasitol. 27, 222 (2011).
13
Tanabe K., et al., Curr. Biol. 20, 1283 (2010).
14
Carter R., Mendis K. N., Clin. Microbiol. Rev. 15, 564 (2002).
15
Pepin J., The Origins of AIDS (Cambridge Univ. Press, Cambridge, 2011).
16
Kantele A., Jokiranta T. S., Clin. Infect. Dis. 52, 1356 (2011).
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