ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND

AGING (original) (raw)

Abstract

▪ Abstract

Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.

Article metrics loading...

/content/journals/10.1146/annurev.med.46.1.223

1995-02-01

2024-09-30

Full text loading...