Cellular Sensing of Viral DNA and Viral Evasion Mechanisms (original) (raw)
Abstract
Mammalian cells detect foreign DNA introduced as free DNA or as a result of microbial infection, leading to the induction of innate immune responses that block microbial replication and the activation of mechanisms that epigenetically silence the genes encoded by the foreign DNA. A number of DNA sensors localized to a variety of sites within the cell have been identified, and this review focuses on the mechanisms that detect viral DNA and how the resulting responses affect viral infections. Viruses have evolved mechanisms that inhibit these host sensors and signaling pathways, and the study of these antagonistic viral strategies has provided insight into the mechanisms of these host responses. The field of cellular sensing of foreign DNA is in its infancy, but our currently limited knowledge has raised a number of important questions for study.
Article metrics loading...
/content/journals/10.1146/annurev-micro-091313-103409
2014-09-08
2024-10-23
Full text loading...
/deliver/fulltext/micro/68/1/annurev-micro-091313-103409.html?itemId=/content/journals/10.1146/annurev-micro-091313-103409&mimeType=html&fmt=ahah
- Article Type: Review Article
Most Read This Month
Article
content/journals/micro
Journal
5
3
false
en