TRANSCRIPTIONAL REGULATION DURING B CELL

DEVELOPMENT (original) (raw)

Abstract

▪ Abstract

Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell development. In this review the roles of transcription factors and coactivators are discussed with respect to changes in expression patterns of various genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobulin gene V(D)J recombination, somatic hypermutation, and isotype switch recombination.

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/content/journals/10.1146/annurev.immunol.16.1.163

1998-04-01

2025-01-12

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