Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis (original) (raw)

Abstract

Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.

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/content/journals/10.1146/annurev.micro.61.080706.093426

2007-10-13

2024-10-23

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