Role of TGF-β in Vascular Development and Vascular Reactivity (original) (raw)
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Review Articles| February 23 1998
a Cardiovascular Biology Laboratory,Harvard School of Public Health,
b Department of Medicine, Harvard Medical School,
c Pulmonary, and
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a Cardiovascular Biology Laboratory,Harvard School of Public Health,
b Department of Medicine, Harvard Medical School,
d Cardiovascular Divisions, Brigham and Women’s Hospital, Boston, Mass., USA
Search for other works by this author on:
a Cardiovascular Biology Laboratory,Harvard School of Public Health,
b Department of Medicine, Harvard Medical School,
d Cardiovascular Divisions, Brigham and Women’s Hospital, Boston, Mass., USA
Search for other works by this author on:
Mineral and Electrolyte Metabolism (1998) 24 (2-3): 136–143.
Abstract
Transforming growth factor-β (TGF-β) is the prototypic member of a large family of structurally related proteins. Three vertebrate TGF-β isoforms have been identified and termed TGF-β1, TGF-β2, and TGF-β3, respectively. In addition, two receptors of the serine/threonine kinase family termed type I and II have also been identified. In this review, we focused our attention on the effects of TGF-β on vascular development and vascular reactivity. The critical role of the TGF-β1 and the TGF-β type II receptor in blood vessel formation in the yolk sac has been demonstrated by gene deletion experiments. Recent investigations have also shown that isoforms of TGF-β play a critical role in smooth muscle cell differentiation. And, finally, a role for TGF-β1 in the regulation of vascular tone and reactivity has been suggested by studies demonstrating that TGF-β1 can inhibit the production of potent vasodilators (such as nitric oxide) and stimulate the production of potent vasoconstrictors (such as endothelin). Taken together, these studies suggest that TGF-β plays a critical role in blood vessel development and vascular function.
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1998
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