Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome (original) (raw)
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Research Articles| February 11 2008
aImmunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran;
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bCenter for Pediatrics and Adolescent Medicine, Freiburg University, Freiburg, and
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aImmunology, Asthma and Allergy Research Institute, Medical Sciences/University of Tehran, Tehran, Iran;
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bCenter for Pediatrics and Adolescent Medicine, Freiburg University, Freiburg, and
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bCenter for Pediatrics and Adolescent Medicine, Freiburg University, Freiburg, and
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dServicio de Inmunologia, Hospital Son Dureta, Palma de Mallorca, and
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fDepartment of Pediatrics, University of Milan, Fondazione Policlinico IRCCS, Milano, and
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eImmunology Unit, Hospital Vall d’Hebron, Barcelona, Spain;
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hDepartment of Clin. Immunol. Allergol, Masaryk University, St. Anne’s University Hospital, Brno, Czech Republic;
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iGrupo de Inmunodeficiencias Primarias, Universidad de Antioquia, Medellín, Colombia;
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jImmunology Division, Hacettepe University Children’s Hospital, Ankara, and
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kDepartment of Pediatric Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey;
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lDepartment of Pediatric Pulmonology, Allergy and Clinical Immunology, 3rd Department of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland;
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gDepartment of Pediatrics and Institute of Molecular Medicine A. Nocivelli, University of Brescia, Spedali Civili, Brescia, Italy;
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cDr. v. Haunersches Kinderspital and Division of Clinical Pharmacology, Ludwigs Maximilians University, Munich, Germany;
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cDr. v. Haunersches Kinderspital and Division of Clinical Pharmacology, Ludwigs Maximilians University, Munich, Germany;
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mDepartment of Medicine, University of Washington School of Medicine, Seattle, Wash., USA;
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nDepartment of Immunology and Molecular Pathology, Royal Free Hospital and University College London, London, UK
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nDepartment of Immunology and Molecular Pathology, Royal Free Hospital and University College London, London, UK
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Int Arch Allergy Immunol (2008) 146 (3): 190–194.
Accepted:
October 22 2007
Published Online:
February 11 2008
Citation
Mehdi Yeganeh, Philipp Henneke, Nima Rezaei, Stephan Ehl, Doerte Thiel, Nuria Matamoros, Cristina Pietrogrande, Teresa Espanol, Jiri Litzman, Jose L. Franco, Ozden Sanal, Sara S. Kilic, Anna Breborowicz, Alessandro Plebani, Ellen Renner, Simon Rothenfusser, Thomas R. Hawn, Cristina Woellner, Bodo Grimbacher; Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome. _Int Arch Allergy Immunol 1 June 2008; 146 (3): 190–194. https://doi.org/10.1159/000115886
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Abstract
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with ‘cold’ abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-α and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES.
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2008
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