Interphase cytogenetics reveals somatic pairing of chromosome 17 centromeres in normal human brain tissue, but no trisomy 7 or sex-chromosome loss (original) (raw)
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1991
This article was originally published in
Cytogenetics and Cell Genetics
Commentaries| May 13 2008
aDepartments of Neurology and
bCytochemistry and Cytometry, Leiden University, Leiden (The Netherlands)
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aDepartments of Neurology and
bCytochemistry and Cytometry, Leiden University, Leiden (The Netherlands)
Search for other works by this author on:
aDepartments of Neurology and
Search for other works by this author on:
bCytochemistry and Cytometry, Leiden University, Leiden (The Netherlands)
Search for other works by this author on:
bCytochemistry and Cytometry, Leiden University, Leiden (The Netherlands)
Search for other works by this author on:
Cytogenetics and Cell Genetics (1991) 56 (3-4): 214–216.
Abstract
Nuclei isolated from normal human brain tissue, collected from six autopsies, were hybridized with a panel of nine satellite DNA probes specific for the centromeric regions of chromosomes 1, 6, 7, 10, 11, 17, 18, and the X and Y chromosomes. The results did not confirm the recently reported trisomy 7 and loss of sex chromosomes observed in metaphases obtained from normal brain tissue after short-term cultures; however, cells of all six brains displayed somatic pairing of the chromosome 17 centromeres in approximately 50% of the nuclei.
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© 1991 S. Karger AG, Basel
1991
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