Flavonoid Inhibition of Enzymic and Nonenzymic Lipid Peroxidation in Rat Liver Differs from Its Influence on the Glutathione-Related Enzymes (original) (raw)
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Research Articles| June 10 2008
aDepartment of Pharmacology, School of Pharmacy, University of Granada, Spain;
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bDepartment of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Spain
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aDepartment of Pharmacology, School of Pharmacy, University of Granada, Spain;
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Felipe Sanchez de la Cuesta
bDepartment of Pharmacology and Therapeutics, School of Medicine, University of Malaga, Spain
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Pharmacology (1995) 51 (2): 127–133.
Abstract
Eight flavonoids were tested for their antiperoxidative activities against lipid peroxidation induced in liver cell membranes either by nonenzymic way (ascorbic acid-Fe2+ system, FeAs) or by enzymic way (arachidonic acid, AA). When lipid peroxidation is induced by FeAs, the order in the inhibitory potency for the different flavonoids assayed is: (–)-epicatechin ≈ luteolin > quercetin ≈ (+)-catechin > delphinidin > kaempferol >> apigenin > naringenin. However, when lipid peroxidation is induced by AA, the potency order is markedly modified: delphinidin > (–)-epicatechin > (+)-catechin > kaempferol > quercetin > luteolin > naringenin > apigenin. These flavonoids were also tested for their influence on glutathione-related enzymes, which constitute one of the aim physiological antioxidant systems. It is concluded that the antiperoxidative effect shown by most of the flavonoids is exerted without modifying these enzymes.
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© 1995 S. Karger AG, Basel
1995
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