Effects of Thymus Grafts in Nude Mice Transplanted with Human Malignant Tumors (original) (raw)
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1979
This article was originally published in
Experimental Cell Biology
Research Articles| October 03 2008
Pathological-Anatomical Institute, Herlev Amts Sygehus, University of Copenhagen, Herlev and Pathological-Anatomical Institute, Kommunehospitalet, Copenhagen
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Pathological-Anatomical Institute, Herlev Amts Sygehus, University of Copenhagen, Herlev and Pathological-Anatomical Institute, Kommunehospitalet, Copenhagen
Search for other works by this author on:
Pathological-Anatomical Institute, Herlev Amts Sygehus, University of Copenhagen, Herlev and Pathological-Anatomical Institute, Kommunehospitalet, Copenhagen
Search for other works by this author on:
Experimental Cell Biology (1979) 47 (6): 409–429.
Received:
November 21 1978
Accepted:
January 08 1979
Published Online:
October 03 2008
Abstract
The effects of neonatal thymus grafts implanted in nude mice previously transplanted with three different human malignant tumors – an adenocarcinoma of the colon, a malignant melanoma and a Burkitt’s lymphoma – were studied. In all immunologically reconstituted animals tumors were rejected. Tumor rejection started 2–3 weeks after thymus implantation, and was completed after 3–6 weeks. Histological examination of lymphoid tissues showed a correlation between immunological reconstitution and tumor rejection. The rejection process showed a characteristic histologic picture with 3 phases – an early, an intermediate and a late phase – these were similar in the three tumor types examined. The possible mechanisms of reconstitution and tumor rejection are discussed.
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© 1979 S. Karger AG, Basel
1979
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