The Role of Antibodies in Natural and Acquired Resistance of Mice to Vesicular Stomatitis Virus (original) (raw)
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1988
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Experimental Cell Biology
Research Articles| October 07 2008
Institute of Pathology, Department for Experimental Pathology, University Hospital, Zürich, Switzerland
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Institute of Pathology, Department for Experimental Pathology, University Hospital, Zürich, Switzerland
Search for other works by this author on:
Institute of Pathology, Department for Experimental Pathology, University Hospital, Zürich, Switzerland
Search for other works by this author on:
Institute of Pathology, Department for Experimental Pathology, University Hospital, Zürich, Switzerland
Search for other works by this author on:
Institute of Pathology, Department for Experimental Pathology, University Hospital, Zürich, Switzerland
Search for other works by this author on:
Experimental Cell Biology (1988) 56 (4): 175–180.
Abstract
Mice infected with live vesicular stomatitis virus (VSV) produced primary antibody responses more efficiently (with doses > 102 pfu) than those injected with UV-inactivated VSV ( > 106 pfu) or purified VSV glycoprotein G (equivalent to 107 pfu) by producing neutralizing antibodies. Very low doses of live VSV ( < 102 pfu) failed to prime mice. Normal mouse serum had the capacity to inactivate VSV by heat-labile and immunoglobulin-mediated mechanisms in vitro independently of specifically induced antibodies. Studies using B cell-depleted agammaglobulineamic mice showed that their serum lacked VSV-neutralizing capacity in vitro and that naturally resistant mice became susceptible to VSV-induced paralytic disease which could be prevented by adoptive transfer of immune but also of normal serum.
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© 1988 S. Karger AG, Basel
1988
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