Differential Effects of Interferon on the MHC Expression of Human Lymphocytes: Enhanced Expression of HLA without Effect on Ia (original) (raw)
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Research Articles| July 28 2009
Division of Pathology, Bureau of Biologics, Food and Drug Administration, and the Clinical Immunology Division, Clinical Investigation Department, Naval Medical Research Institute, Bethesda, Md.
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Division of Pathology, Bureau of Biologics, Food and Drug Administration, and the Clinical Immunology Division, Clinical Investigation Department, Naval Medical Research Institute, Bethesda, Md.
Search for other works by this author on:
International Archives of Allergy and Applied Immunology (1979) 60 (1): 101–105.
Abstract
HLA antigens are the principal serologically detectable products of the major histocompatibility complex (MHC), and they function as targets for antibody-mediated and cell-mediated cytolysis. Anti-HLA sera were used in a quantitative absorption procedure to study the effect of interferon (IF) treatment on HLA expression. This study was undertaken since IF has been shown to play an important role in the regulation of cell division and function. We found that IF enhanced the expression of HLA antigens on human peripheral blood lymphocytes by 8-fold. This increase in HLA expression was specific for both the HLA-A and HLA-B regions of the MHC. There was no increase in the expression of the la region after IF treatment as opposed to the HLA region. Since IF is an antiviral agent and it also enhances the expression of the HLA-A and HLA-B regions, it may be involved in the elimination of virus-infected cells by A and B identical effector cells.
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© 1979 S. Karger AG, Basel
1979
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