A Contiguous Network of Dendritic Antigen-Presenting Cells within the Respiratory Epithelium (original) (raw)
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Research Articles| August 06 2009
Clinical Immunology Research Unit, Children’s Medical Research Foundation, Princess Margaret Hospital, Perth, and Department of Anatomy and Human Biology, University of Western Australia
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Clinical Immunology Research Unit, Children’s Medical Research Foundation, Princess Margaret Hospital, Perth, and Department of Anatomy and Human Biology, University of Western Australia
Search for other works by this author on:
Clinical Immunology Research Unit, Children’s Medical Research Foundation, Princess Margaret Hospital, Perth, and Department of Anatomy and Human Biology, University of Western Australia
Search for other works by this author on:
Clinical Immunology Research Unit, Children’s Medical Research Foundation, Princess Margaret Hospital, Perth, and Department of Anatomy and Human Biology, University of Western Australia
Search for other works by this author on:
Clinical Immunology Research Unit, Children’s Medical Research Foundation, Princess Margaret Hospital, Perth, and Department of Anatomy and Human Biology, University of Western Australia
Search for other works by this author on:
International Archives of Allergy and Applied Immunology (1990) 91 (2): 155–159.
Received:
September 15 1989
Accepted:
October 12 1989
Published Online:
August 06 2009
Abstract
This study utilises a simple technique to section airway epithelium in a plane parallel to the basement membrane, thus providing a unique plan view of the intra-epithelial cell populations. Immunoperoxidase staining of these tissue sections for class II major histocompatibility complex la antigen reveals a virtually contiguous network of Ia-positive dendritic cells (DC) within the epithelium. These DC are shown to be capable of binding inhaled antigens in vivo in a form suitable for presentation to T cells. The strategic location of these cells and the fact that they account for virtually all staining in the airway epithelium during the steady state is convincing evidence that the DC network functions as the ‘first line of defence’ in surveillance for inhaled antigens and further suggests a major role for the intra-epithelial DC in allergic and infectious disease(s) in the respiratory tract.
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© 1990 S. Karger AG, Basel
1990
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