Production of Interleukin-4 and Other Cytokines following Stimulation of Mast Cell Lines and in vivo Mast Cells/Basophils (original) (raw)
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Research Articles| August 07 2009
aThe Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA;
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aThe Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA;
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aThe Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA;
bLautenberg Center for Tumor Immunology, Hebrew University-Hadassah Medical Center, Jerusalem, Israel;
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aThe Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA;
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cDepartment of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Md., USA;
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dDepartment of Medicine, Uniformed Services University of the Health Sciences;
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eLaboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA
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aThe Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA;
cDepartment of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Md., USA;
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International Archives of Allergy and Applied Immunology (1991) 94 (1-4): 137–140.
Abstract
Interleukin-3 (IL-3)-dependent mast cell lines, upon stimulation by calcium ionophores or by FcεRI cross-linking, express mRNA for, and secrete, a distinct pattern of cytokines, similar to those secreted by cloned mouse T cells of the TH2 type. The mast-cell-derived cytokines include IL-3, IL-4, IL-5 and IL-6. Not only in vitro mast cell lines, but also in vivo derived peritoneal mast cells secrete cytokines. An in vivo derived cell, in mouse spleen and bone marrow, secretes IL-4 and other cytokines upon stimulation with calcium ionophores or by FcεRI cross-linking or FcγRII cross-linking. The IL-4-producing cells are highly enriched in the FcεR+ subset of spleen and bone marrow cells. These FcεR+ cells produce large amounts of IL-4, and they have characteristics similar to those of immature mast cells and/or basophils. It is possible that cytokines produced by mast cells and/or basophils participate in allergic inflammatory diseases.
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© 1991 S. Karger AG, Basel
1991
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