Inhibition of Primary ADP-Induced Platelet Aggregation in Normal Subjects after Administration of Nitrofurantoin (Furadantin) (original) (raw)

Research Article Free access | 10.1172/JCI107437

1Department of Medicine, Northwestern University School of Medicine and the Veterans Administration Research Hospital, Chicago, Illinois 60611

Find articles by Rossi, E. in:[JCI](/search/results?q=author.first%5Fname%3A%22Ennio C.%22+author.last%5Fname%3A%22Rossi%22&search%5Ftype=advanced) |PubMed |Google Scholar

1Department of Medicine, Northwestern University School of Medicine and the Veterans Administration Research Hospital, Chicago, Illinois 60611

Find articles by Levin, N. in:[JCI](/search/results?q=author.first%5Fname%3A%22Nathan W.%22+author.last%5Fname%3A%22Levin%22&search%5Ftype=advanced) |PubMed |Google Scholar

Published October 1, 1973 -More info

Published October 1, 1973 -Version history

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Abstract

The evidence indicating that platelets may play a role in the occurrence of certain thromboembolic phenomena has stimulated a search for inhibitors of platelet function. This report presents data to indicate that nitrofurantoin is a potent inhibitor of primary ADP-induced platelet aggregation. The addition of 10 μM nitrofurantoin to citrated platelet-rich plasma obtained from 12 normal subjects produced a 29±6% (2 SD) inhibition of the velocity of platelet aggregation induced by 2 μM ADP. The inhibitory effect of nitrofurantoin demonstrated competitive kinetics in respect to ADP. The intravenous (180 mg) or oral (200 mg) administration of nitrofurantoin produced a serum nitrofurantoin concentration ranging from 2.7 to 23 μM in 28 normal subjects. Platelet-rich plasma obtained from these subjects demonstrated inhibition of the velocity of ADP-induced platelet aggregation that correlated with the log of the serum nitrofurantoin concentration (P < 0.001). Collagen-induced platelet aggregation was also inhibited in a dose-related manner, and the bleeding time was significantly prolonged in the two subjects with the highest serum nitrofurantoin concentration. These studies indicate that nitrofurantoin in vivo inhibits platelet function to a degree that is proportional to the serum nitrofurantoin concentration.

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