Widespread long-term gene transfer to mouse skeletal muscles and heart. (original) (raw)

Research Article Free access | 10.1172/JCI115902

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Find articles by Stratford-Perricaudet, L. in:[JCI](/search/results?q=author.first%5Fname%3A%22L D%22+author.last%5Fname%3A%22Stratford-Perricaudet%22&search%5Ftype=advanced) |PubMed |Google Scholar

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Find articles by Makeh, I. in:JCI |PubMed |Google Scholar

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Find articles by Perricaudet, M. in:JCI |PubMed |Google Scholar

Institut Gustave Roussy, Centre National de la Recherche Scientifique, UA 1301, Villejuif, France.

Find articles by Briand, P. in:JCI |PubMed |Google Scholar

Published August 1, 1992 -More info

Published August 1, 1992 -Version history

View PDF

Abstract

Successful treatment of muscular disorders awaits an adapted gene delivery protocol. The clinically applicable technique used for hematopoietic cells which is centered around implantation of retrovirally modified cells may not prove sufficient for a reversal of phenotype when muscle diseases are concerned. We report here efficient, long-term in vivo gene transfer throughout mouse skeletal and cardiac muscles after intravenous administration of a recombinant adenovirus. This simple, direct procedure raises the possibility that muscular degenerative diseases might one day be treatable by gene therapy.

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history