Transgenic expression of tpr-met oncogene leads to development of mammary hyperplasia and tumors. (original) (raw)

Research Article Free access | 10.1172/JCI118744

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov

Find articles by Liang, T. in:[JCI](/search/results?q=author.first%5Fname%3A%22T J%22+author.last%5Fname%3A%22Liang%22&search%5Ftype=advanced) |PubMed |Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov

Find articles by Reid, A. in:[JCI](/search/results?q=author.first%5Fname%3A%22A E%22+author.last%5Fname%3A%22Reid%22&search%5Ftype=advanced) |PubMed |Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov

Find articles by Xavier, R. in:JCI |PubMed |Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov

Find articles by Cardiff, R. in:[JCI](/search/results?q=author.first%5Fname%3A%22R D%22+author.last%5Fname%3A%22Cardiff%22&search%5Ftype=advanced) |PubMed |Google Scholar

Department of Medicine, Massachusetts General Hospital, Boston 02114, USA. liangt@bdg.niddk.nih.gov

Find articles by Wang, T. in:[JCI](/search/results?q=author.first%5Fname%3A%22T C%22+author.last%5Fname%3A%22Wang%22&search%5Ftype=advanced) |PubMed |Google Scholar

Published June 15, 1996 -More info

Published June 15, 1996 -Version history

View PDF

Abstract

Receptor tyrosine kinases are important in cell signal transduction and proliferation. Abnormal expression of tyrosine kinases often leads to malignant transformation. C-met is a tyrosine kinase receptor and its ligand is hepatocyte growth factor (HGF). HGF/c-met plays diverse role in regulation of cell growth, shape and movement. Constitutively activated met, such as tpr-met, is a potent oncogene in vitro, but its carcinogenic role in vivo remains unclear. Our study demonstrates that expression of tpr-met leads to development of mammary tumors and other malignancies in transgenic mice, and suggests that deregulated met expression may be involved in mammary carcinogenesis.

Version history