Potentiation of antidepressant medications by phase advance of the sleep-wake cycle (original) (raw)
Publication: American Journal of Psychiatry
Abstract
Four patients with major depression who were unresponsive to antidepressant medications rapidly improved and remained euthymic after an advance of the sleep-wake cycle. Phase advance of the sleep-wake cycle and antidepressant treatment may have complementary effects on the circadian system. The authors suggest that the combination may be useful in treating drug nonresponders and in hastening response to antidepressant drugs.
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American Journal of Psychiatry
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Published in print: May 1985
Published online: 1 April 2006
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