Ketoconazole administration in hypercortisolemic depression (original) (raw)
Publication: American Journal of Psychiatry
Abstract
Ketoconazole, an antiglucocorticoid drug, was administered to 10 hypercortisolemic depressed patients for up to 6 weeks. Three patients dropped out because of side effects or intercurrent illness. The remaining seven had significant ketoconazole-associated decreases in serum cortisol levels and in depression ratings. Antiglucocorticoid agents may be useful probes for investigating the sequelae of hypercortisolemia in patients with major depression.
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American Journal of Psychiatry
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Published in print: May 1993
Published online: 1 April 2006
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