Recent advances of novel targeted therapy in non-small cell lung cancer (original) (raw)
References
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Muray T, Thun MJ: Cancer Statistics, 2008. Ca Cancer J Clin. 2008, 58: 71-96. 10.3322/CA.2007.0010. ArticlePubMed Google Scholar
Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. Ca Cancer J Clin. 2005, 55: 74-108. ArticlePubMed Google Scholar
Weinberg RA: Growth factor receptors can function as oncoproteins. The biology of cancer. Edited by: Elizabeth Zayatz. 2007, New York: Garland Science, 129-131. 1 Google Scholar
Sporn MB, Todaro GJ: Autocrine secretion and malignant transformation of cells. N Engl J Med. 1980, 303: 878-80. ArticleCASPubMed Google Scholar
Citri A, Yarden Y: EGF-ERBB signaling: towards the systems level. Nat Rev Mol Cell Biol. 2006, 7: 505-16. 10.1038/nrm1962. ArticleCASPubMed Google Scholar
Hynes NH, Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer. 2005, 5: 341-54. 10.1038/nrc1609. ArticleCASPubMed Google Scholar
Fukuoka M, Yano S, Giaccone G, Tumura T, Nakagawa K, Douillard JY, Nishiwaki Y, Vansteenkiste J, Kudoh S, Rischin D, Eek R, Horai T, Noda K, Takata I, Smit E, Averbuch S, Macleod A, Feyereislova A, Dong RP, Badelga J: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small cell lung cancer (the IDEAL 1 Trial). J Clin Oncol. 2003, 21: 2237-2246. 10.1200/JCO.2003.10.038. ArticleCASPubMed Google Scholar
Kris MG, Natale RB, Herbst RS, Lynch TJ, Prager D, Belani CP, Schiller JH, Kelly K, Spiridonidis H, Sandler A, Albain KS, Cella D, Wolf MK, Averbuch SD, Ochs JJ, Kay AC: Efficacy of gefitinib, and inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA. 2003, 290: 2149-2158. 10.1001/jama.290.16.2149. ArticleCASPubMed Google Scholar
Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, Thongprasert S, Tan EH, Pemberton K, Archer V, Carroll K: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomized, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005, 366: 1527-1537. 10.1016/S0140-6736(05)67625-8. ArticleCASPubMed Google Scholar
Crinò L, Cappuzzo F, Zatloukal P, Reck M, Pesek M, Thompson JC, Ford HE, Hirsch FR, Varella-Garcia M, Ghiorghiu S, Duffield EL, Armour AA, Speake G, Cullen M: Gefitinib versus vinorelbine in chemotherapy-naive elderly patients with advanced non-small-cell lung cancer (INVITE): a randomized, phase II study. J Clin Oncol. 2008, 26: 4253-4260. 10.1200/JCO.2007.15.0672. ArticlePubMedCAS Google Scholar
Pérez-Soler R, Chachoua A, Hammond LA, Rowinsky EK, Huberman M, Karp D, Rigas J, Clark GM, Santabárbara P, Bonomi P: Determinants of tumor response and survival with erlotinib in patients with non-small-cell lung cancer. J Clin Oncol. 2004, 22: 3238-3247. 10.1200/JCO.2004.11.057. ArticlePubMedCAS Google Scholar
Perez-Soler R: Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non small-cell lung cancer. Clin Lung Cancer. 2004, 6 (Suppl 1): S20-S23. 10.3816/CLC.2004.s.010. ArticleCASPubMed Google Scholar
Herbst RS, Johnson DH, Mininberg E, Carbone DP, Henderson T, Kim ES, Blumenschein G, Lee JJ, Liu DD, Truong MT, Hong WK, Tran H, Tsao A, Xie D, Ramies DA, Mass R, Seshagiri S, Eberhard DA, Kelley SK, Sandler A: Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer. J Clin Oncol. 2005, 23: 2544-2555. 10.1200/JCO.2005.02.477. ArticleCASPubMed Google Scholar
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, van Kooten M, Dediu M, Findlay B, Tu D, Johnston D, Bezjak A, Clark G, Santabárbara P, Seymour L, National Cancer Institute of Canada Clinical Trials Group: Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005, 353: 123-132. 10.1056/NEJMoa050753. ArticleCASPubMed Google Scholar
Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, Levitan N, Gressot L, Vincent M, Burkes R, Coughlin S, Kim Y, Berille J: Prospective randomized trial of docetaxel versus best supportive care in patients with nonsmall-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000, 18: 2095-2103. CASPubMed Google Scholar
Bezjak A, Tu D, Seymour L, Clark G, Trajkovic A, Zukin M, Ayoub J, Lago S, de Albuquerque Ribeiro R, Gerogianni A, Cyjon A, Noble J, Laberge F, Chan RT, Fenton D, von Pawel J, Reck M, Shepherd FA, National Cancer Institute of Canada Clinical Trials Group Study BR.21: Symptom improvement in lung cancer patients treated with erlotinib: quality of life analysis of the national cancer institute of Canada clinical trials group study BR.21. J Clin Oncol. 2006, 24: 3831-3837. 10.1200/JCO.2006.05.8073. ArticleCASPubMed Google Scholar
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Rosell R, Miller V, Natale RB, Schiller JH, Von Pawel J, Pluzanska A, Gatzemeier U, Grous J, Ochs JS, Averbuch SD, Wolf MK, Rennie P, Fandi A, Johnson DH: Gefitinib in combination with gemcitabine and cisplatin in advanced non small-cell lung cancer: a phase III trial – INTACT 1. J Clin Oncol. 2004, 22: 777-784. 10.1200/JCO.2004.08.001. ArticleCASPubMed Google Scholar
Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, Scagliotti G, Rosell R, Oliff I, Reeves JA, Wolf MK, Krebs AD, Averbuch SD, Ochs JS, Grous J, Fandi A, Johnson DH: Gefitinib in combination with paclitaxel and carboplatin in advanced nonsmall-cell lung cancer: a phase III trial – INTACT 2. J Clin Oncol. 2004, 22: 785-794. 10.1200/JCO.2004.07.215. ArticleCASPubMed Google Scholar
Herbst RS, Prager D, Hermann R, Fehrenbacher L, Johnson BE, Sandler A, Kris MG, Tran HT, Klein P, Li X, Ramies D, Johnson DH, Miller VA, TRIBUTE Investigator Group: TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol. 2005, 23: 5892-5899. 10.1200/JCO.2005.02.840. ArticleCASPubMed Google Scholar
Gatzemeier U, Pluzanska A, Szczesna A, Kaukel E, Roubec J, De Rosa F, Milanowski J, Karnicka-Mlodkowski H, Pesek M, Serwatowski P, Ramlau R, Janaskova T, Vansteenkiste J, Strausz J, Manikhas GM, Von Pawel J: Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol. 2007, 25: 1545-1552. 10.1200/JCO.2005.05.1474. ArticleCASPubMed Google Scholar
Gandara DR, Gumerlock PH: Epidermal growth factor receptor tyrosine kinase inhibitors plus chemotherapy: case close or is the jury still out?. J Clin Oncol. 2005, 25: 5856-5858. 10.1200/JCO.2005.05.030. Article Google Scholar
Tracy S, Mukohara T, Hansen M, Meyerson M, Johnson BE, Jänne PA: Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255. Cancer Res. 2004, 64: 7241-7244. 10.1158/0008-5472.CAN-04-1905. ArticleCASPubMed Google Scholar
Shepherd FA: Molecular selection of patients for first-line treatment of advanced non-small-cell lung cancer with epidermal growth factor inhibitors: not quite ready for prime time. J Clin Oncol. 2008, 26: 2426-2427. 10.1200/JCO.2007.15.4286. ArticlePubMed Google Scholar
Khambata-Ford S, Garrett CR, Meropol NJ, Basik M, Harbison CT, Wu S, Wong TW, Huang X, Takimoto CH, Godwin AK, Tan BR, Krishnamurthi SS, Burris HA, Poplin EA, Hidalgo M, Baselga J, Clark EA, Mauro DJ: Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol. 2007, 25: 3230-3237. 10.1200/JCO.2006.10.5437. ArticleCASPubMed Google Scholar
Van Cutsem E, Lang I, D'haens G, Moiseyenko V, Zaluski J, Folprecht G, Tejpar S, Kisker O, Stroh C, Rougier P: KRAS status and efficacy in the first-line treatment of patients with metastatic colorectal cancer treated with FOLFIRI without or without cetuximab [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 2- Google Scholar
Bokemeyer C, Bondarenko I, Hartmann JT, De Braud FG, Volovat C, Nippgen J, Stroh C, Celik I, Koralewski P: KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer with FOLFOX with or without cetuximab: the OPUS experience [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 4000- Google Scholar
Lacouture ME: Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat Rev Cancer. 2006, 6: 803-812. 10.1038/nrc1970. ArticleCASPubMed Google Scholar
Clynes RA, Towers TL, Presta LG, Ravetch JV: Inhibitory Fc receptors modulate in vivo cytotoxicty against tumor targets. Nature Med. 2000, 6: 443-446. 10.1038/74704. ArticleCASPubMed Google Scholar
Rossi A, Maione P, Gridelli C: Cetuximab in advanced non-small-cell lung cancer. Crit Rev Oncol Hematol. 2006, 59: 139-49. 10.1016/j.critrevonc.2006.02.006. ArticlePubMed Google Scholar
Herbst RS, Chansky K, Kelly K, Atkins JN, Davies AM, Dakhil SR, Albain KS, Kim ES, Crowley JJ, Gandara DR: A phase II randomized selection trial evaluating concurrent chemotherapy plus cetuximab or chemotherapy followed by cetuximab in patients with advanced nonsmall cell lung cancer (NSCLC): final report of SWOG 0342 [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7545- Google Scholar
Belani CP, Ramalingam S, Schreeder M, Steis R, Guidice R, Marshland T, Butler B: Phase II study of cetuximab in combination with carboplatin and docetaxel for patients with advanced/metastatic non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7643- Google Scholar
Butts CA, Bodkin D, Middleman EL, Englund CW, Ellison D, Alam YZ, Pautret V, Weber M, Kreisman H, Shepherd FA: Gemcitabine/platinum alone or in combination with cetuximab as first-line treatment for advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7539- Google Scholar
Rosell R, Robinet G, Szczesna A, Ramlau R, Constenla M, Mennecier BC, Pfeifer W, O'Byrne KJ, Welte T, Kolb R, Pirker R, Chemaissani A, Perol M, Ranson MR, Ellis PA, Pilz K, Reck M: Randomized phase II study of cetuximab plus cisplatin/vinorelbine compared with cisplatin/vinorelbine alone as first-line therapy in EGFR-expressing advanced non-small-cell lung cancer. Ann Oncol. 2008, Google Scholar
Pirker R, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Park K, Gatzemeier U, Bajeta E, Emig M, Pereira JR: FLEX: A randomized, multicenter, phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 3-10.1200/JCO.2008.16.1190. Article Google Scholar
Baselga J, Pfister D, Cooper MR, Cohen R, Burtness B, Bos M, D'Andrea G, Seidman A, Norton L, Gunnett K, Falcey J, Anderson V, Waksal H, Mendelsohn J: Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol. 2000, 18: 904-914. CASPubMed Google Scholar
Freeman D, Sun J, Bass R, Jung K, Ogbagabriel S, Elliott G, Radinsky R: Panitumumab and cetuximab epitope mapping and in vitro activity [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 14536- Google Scholar
Schmiedel J, Blaukat A, Li S, Knöchel T, Ferguson KM: Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell. 2008, 13: 365-373. 10.1016/j.ccr.2008.02.019. ArticlePubMed CentralCASPubMed Google Scholar
Weiner LM, Belldegrun A, Rowinsky E, Crawford J, Lockbaum P, Huang S, Arends R, Schwab G, Figlin R: Updated results from a dose and schedule study of panitumumab (ABX-EGF) monotherapy, in patients with advanced solid malignancies [abstract]. J Clin Oncol. 2005, 23 (Suppl 16): 3059- Google Scholar
Socinski MA: Antibodies to the epidermal growth factor receptor in non-small cell lung cancer: current status of matuzumab and panitumumab. Clin Cancer Res. 2007, 13 (Suppl 15): 4597-4601. 10.1158/1078-0432.CCR-07-0335. ArticleCAS Google Scholar
Crawford J, Sandler AB, Hammond LA, Schiller J, Belani C, Kozloff M, Johnson D, Fleishman A, Lee S, Takeshita K: ABX-EGF in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer (NSCLC) [abstract]. J Clin Oncol. 2004, 22 (Suppl 14): 7083- Google Scholar
Vanhoefer U, Tewes M, Rojo F, Dirsch O, Schleucher N, Rosen O, Tillner J, Kovar A, Braun AH, Trarbach T, Seeber S, Harstrick A, Baselga J: Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J Clin Oncol. 2004, 22: 175-184. 10.1200/JCO.2004.05.114. ArticleCASPubMed Google Scholar
Kollmannsberger C, Schittenhelm M, Honecker F, Tillner J, Weber D, Oechsle K, Kanz L, Bokemeyer C: A phase I study of the humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody EMD 72000 (matuzumab) in combination with paclitaxel in patients with EGFR-positive advanced non-small-cell lung cancer (NSCLC). Ann Oncol. 2006, 17: 1007-1013. 10.1093/annonc/mdl042. ArticleCASPubMed Google Scholar
Salazar R, Tabernero J, Rojo F, Jimenez E, Montaner I, Casado E, Sala G, Tillner J, Malik R, Baselga J: Dose-dependent inhibition of the EGFR and signalling pathways with the anti-EGFR monoclonal antibody (MAb) EMD 72000 administered every three weeks (q3w). A phase I pharmacokinetic/pharmacodynamic (PK/PD) study to define the optimal biological dose (OBD) [abstract]. J Clin Oncol. 2004, 22 (Suppl 14): 2002- Google Scholar
Rivera F, Vega-Villegas ME, Lopez-Brea MF, Marquez R: Current situation of panitumumab, matuzumab, nimotuzumab and zalutumumab. Acta Oncol. 2008, 47: 9-19. 10.1080/02841860701704724. ArticleCASPubMed Google Scholar
Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ: Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res. 2007, 13: 3913-3921. 10.1158/1078-0432.CCR-06-2610. ArticleCASPubMed Google Scholar
Testa JR, Siegfried JM: Chromosome abnormalities in human non-small cell lung cancer. Cancer Res. 1992, 52 (Suppl 9): 2702s-2706s. CASPubMed Google Scholar
Sharma SV, Bell DW, Settleman J, Haber DA: Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 2007, 7: 169-181. 10.1038/nrc2088. ArticleCASPubMed Google Scholar
Kosaka T, Yatabe Y, Endoh H, Kuwano H, Takahashi T, Mitsudomi T: Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res. 2004, 64: 8919-8923. 10.1158/0008-5472.CAN-04-2818. ArticleCASPubMed Google Scholar
Janne PA, Engelman JA, Johnson BE: Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology. J Clin Oncol. 2005, 23: 3227-3234. 10.1200/JCO.2005.09.985. ArticleCASPubMed Google Scholar
Marchetti A, Martella C, Felicioni L, Barassi F, Salvatore S, Chella A, Camplese PP, Iarussi T, Mucilli F, Mezzetti A, Cuccurullo F, Sacco R, Buttitta F: EGFR mutations in non-small-cell lung caner: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment. J Clin Oncol. 2005, 23: 857-865. 10.1200/JCO.2005.08.043. ArticleCASPubMed Google Scholar
Sordella R, Bell DW, Haber DA, Settleman J: Gefitinib-sensitizing EGFR mutations in lugn cancer activate anti-apoptotic pathways. Science. 2004, 305: 1163-1167. 10.1126/science.1101637. ArticleCASPubMed Google Scholar
Jiang J, Greulich H, Jänne PA, Sellers WR, Meyerson M, Griffin JD: Epidermal growth factor-independent transformation of Ba/F3 cells with cancer-derived epidermal growth factor receptor mutants induces gefitinib sensitive cell cycle progression. Cancer Res. 2005, 65: 8968-8974. 10.1158/0008-5472.CAN-05-1829. ArticleCASPubMed Google Scholar
Predkin L, Wistuba LL: Epidermal growth factor receptor abnormalities in lung cancer. Pathogenic and clinical implications. Ann Diagn Pathol. 2006, 10: 306-315. 10.1016/j.anndiagpath.2006.06.011. Article Google Scholar
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004, 350: 2129-2139. 10.1056/NEJMoa040938. ArticleCASPubMed Google Scholar
Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004, 304: 1497-1500. 10.1126/science.1099314. ArticleCASPubMed Google Scholar
Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA. 2004, 101: 13306-13311. 10.1073/pnas.0405220101. ArticlePubMed CentralCASPubMed Google Scholar
Bell DW, Lynch TJ, Haserlat SM, Harris PL, Okimoto RA, Brannigan BW, Sgroi DC, Muir B, Riemenschneider MJ, Iacona RB, Krebs AD, Johnson DH, Giaccone G, Herbst RS, Manegold C, Fukuoka M, Kris MG, Baselga J, Ochs JS, Haber DA: Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol. 2005, 23: 8081-8092. 10.1200/JCO.2005.02.7078. ArticleCASPubMed Google Scholar
Sequist LV, Bell DW, Lynch TJ, Haber DA: Molecular predictors of response to epidermal growth factor receptor antagonsits in non-small-cell lung cancer. J Clin Oncol. 2007, 25: 587-595. 10.1200/JCO.2006.07.3585. ArticleCASPubMed Google Scholar
Hirsch FR, Dziadziuszko R, Varella-Garcia M, Franklin WA, Gandara DR, Bunn PA: First-generation epidermal growth factor receptor inhibitors in non-small cell lung cancer: clinical impact of the epidermal growth factor receptor fluorescence in situ hybridization assay. J Thorac Oncol. 2008, 3 (Suppl 2): S138-S142. ArticlePubMed Google Scholar
Tsao MS, Sakurada A, Cutz JC, Zhu CQ, Kamel-Reid S, Squire J, Lorimer I, Zhang T, Liu N, Daneshmand M, Marrano P, da Cunha Santos G, Lagarde A, Richardson F, Seymour L, Whitehead M, Ding K, Pater J, Shepherd FA: Erlotinib in lung cancer – molecular and clinical predictors of outcome. N Engl J Med. 2005, 353: 133-144. 10.1056/NEJMoa050736. ArticleCASPubMed Google Scholar
Cappuzzo F, Hirsch FR, Rossi E, Bartolini S, Ceresoli GL, Bemis L, Haney J, Witta S, Danenberg K, Domenichini I, Ludovini V, Magrini E, Gregorc V, Doglioni C, Sidoni A, Tonato M, Franklin WA, Crino L, Bunn PA, Varella-Garcia M: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst. 2005, 97: 643-655. ArticleCASPubMed Google Scholar
Hirsch FR, Varella-Garcia M, Bunn PA, Franklin WA, Dziadziuszko R, Thatcher N, Chang A, Parikh P, Pereira JR, Ciuleanu T, von Pawel J, Watkins C, Flannery A, Ellison G, Donald E, Knight L, Parums D, Botwood N, Holloway B: Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non small-cell lung cancer. J Clin Oncol. 2006, 24: 5034-5042. 10.1200/JCO.2006.06.3958. ArticleCASPubMed Google Scholar
Mok T, Wu Y, Thongprasert S, Yang C, Chu D, Saijo N, Jiang H, Watkins C, Armour A, Masahiro Fukuoka: Phase III, randomised, open-label, first-line study of gefitinib (g) vs carboplatin/paclitaxel (c/p) in clinically selected patients with advanced non-small-cell lung cancer (NSCLC) (IPASS) [abstract]. Ann Oncol. 2008, 19 (Suppl 8): LBA2- Google Scholar
Mok TS, Leong S, Liu X, Ichinose Y, Sriuranpong V, Liam C, Chen Y, Duffield E, Rukazenkov Y, Fukuoka M: Gefitinib (G) vs carboplatin/paclitaxel (C/P) in clinically selected chemonaïve patients (pts) with advanced non-small-cell lung cancer (NSCLC) in Asia (IPASS): randomized, open-label, phase III study. Chicago Multidisciplinary symposium in thoracic oncology 2008: 13–15 November 2008; Chicago. 2008, 100- Google Scholar
Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL, Li LY, Watkins CL, Sellers MV, Lowe ES, Sun Y, Liao ML, Osterlind K, Reck M, Armour AA, Shepherd FA, Lippman SM, Douillard JY: Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomized phase III trial. Lancet. 2008, 372: 1809-1818. 10.1016/S0140-6736(08)61758-4. ArticleCASPubMed Google Scholar
Kelly K, Huang C: Biological agents in non-small cell lung cancer: a review of recent advances and clinical results with a focus on epidermal growth factor receptor and vascular endothelial growth factor. J Thorac Oncol. 2008, 3: 664-673. 10.1097/JTO.0b013e3181758141. ArticlePubMed Google Scholar
Dziadziuszko R, Witta SE, Cappuzzo F, Park S, Tanaka K, Danenberg PV, Barón AE, Crino L, Franklin WA, Bunn PA, Varella-Garcia M, Danenberg KD, Hirsch FR: Epidermal growth factor receptor messenger RNA expression, gene dosage, and gefitinib sensitivity in non-small cell lung cancer. Clin Cancer Res. 2006, 12: 3078-3084. 10.1158/1078-0432.CCR-06-0106. ArticleCASPubMed Google Scholar
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS: K-ras mutations in non-small-cell lung carcinoma: a review. Clin Lung Cancer. 2006, 8: 30-38. 10.3816/CLC.2006.n.030. ArticleCASPubMed Google Scholar
Husgafvel-Pursiainen K, Hackman P, Ridanpää M, Anttila S, Karjalainen A, Partanen T, Taikina-Aho O, Heikkilä L, Vainio H: K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos. Int J Cancer. 1993, 53: 250-256. 10.1002/ijc.2910530213. ArticleCASPubMed Google Scholar
Ahrendt SA, Decker PA, Alawi EA, Zhu Yr YR, Sanchez-Cespedes M, Yang SC, Haasler GB, Kajdacsy-Balla A, Demeure MJ, Sidransky D: Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer. 2001, 92: 1525-1530. 10.1002/1097-0142(20010915)92:6<1525::AID-CNCR1478>3.0.CO;2-H. ArticleCASPubMed Google Scholar
Soung YH, Lee JW, Kim SY, Seo SH, Park WS, Nam SW, Song SY, Han JH, Park CK, Lee JY, Yoo NJ, Lee SH: Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. Virchows Arch. 2005, 446: 483-488. 10.1007/s00428-005-1254-y. ArticleCASPubMed Google Scholar
Eberhard DA, Johnson BE, Amler LC, Goddard AD, Heldens SL, Herbst RS, Ince WL, Jänne PA, Januario T, Johnson DH, Klein P, Miller VA, Ostland MA, Ramies DA, Sebisanovic D, Stinson JA, Zhang YR, Seshagiri S, Hillan KJ: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol. 2005, 23: 5900-5909. 10.1200/JCO.2005.02.857. ArticleCASPubMed Google Scholar
Zhu CQ, da Cunha Santos G, Ding K, Sakurada A, Cutz JC, Liu N, Zhang T, Marrano P, Whitehead M, Squire JA, Kamel-Reid S, Seymour L, Shepherd FA, Tsao MS, National Cancer Institute of Canada Clinical Trials Group Study BR.21: Role of KRAS and EGFR as biomarkers of response to erlotinib in national cancer institute of Canada clinical trials group study BR.21. J Clin Oncol. 2008, 26: 4268-4275. 10.1200/JCO.2007.14.8924. ArticleCASPubMed Google Scholar
Hirsch FR, Varella-Garcia M, Dziadziuszko R, Xiao Y, Gajapathy S, Skokan M, Lin M, O'Neill V, Bunn PA: Fluorescence in situ hybridization subgroup analysis of tribute, a phase III trial of erlotinib plus carboplatin and paclitaxel in non-small cell lung cancer. Clin Cancer Res. 2008, 14: 6317-6323. 10.1158/1078-0432.CCR-08-0539. ArticlePubMed CentralCASPubMed Google Scholar
Kelly K, Huang C: Biologic agents in non-small cell lung cancer: a review of recent advances and clinical results with a focus on epidermal growth factor receptor and vascular endothelial growth factor. J Thorac Oncol. 2008, 3: 664-673. 10.1097/JTO.0b013e3181758141. ArticlePubMed Google Scholar
Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B: EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005, 352: 786-792. 10.1056/NEJMoa044238. ArticleCASPubMed Google Scholar
Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2005, 2: 225-234. 10.1371/journal.pmed.0020225. ArticleCAS Google Scholar
Blencke S, Zech B, Engkvist O, Greff Z, Orfi L, Horváth Z, Kéri G, Ullrich A, Daub H: Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004, 11: 691-701. 10.1016/j.chembiol.2004.02.029. ArticleCASPubMed Google Scholar
Elkind NB, Szentpétery Z, Apáti A, Ozvegy-Laczka C, Várady G, Ujhelly O, Szabó K, Homolya L, Váradi A, Buday L, Kéri G, Német K, Sarkadi B: Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD Gefitinib). Cancer Res. 1839, 65: 1770-1777. 10.1158/0008-5472.CAN-04-3303. Article Google Scholar
Gendreau SB, Ventura R, Keast P, Laird AD, Yakes FM, Zhang W, Bentzien F, Cancilla B, Lutman J, Chu F, Jackman L, Shi Y, Yu P, Wang J, Aftab DT, Jaeger CT, Meyer SM, De Costa A, Engell K, Chen J, Martini JF, Joly AH: Inhibition of the T790M gatekeeper mutant of the epidermal growth factor receptor by EXEL-7647. Clin Cancer Res. 2007, 13: 3713-3723. 10.1158/1078-0432.CCR-06-2590. ArticleCASPubMed Google Scholar
Rizvi N, Kris M, Miller V, Krug L, Bekele S, Dowlati A, Rowland K, Tonda M, Mitchell B, Ruckdeschel J, Chaplen R, Aggarwal N, Gadgeel S: A phase II study of XL647 in Non-small cell lung cancer patients enriched for presence of EGFR mutations, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. San Francisco, CA. 2007, B124- Google Scholar
Spicer J, Calvert H, Vidal L, Azribi F, Perrett R, Shahidi M, Temple G, Futreal A, De Bono J, Plummer R: Activity of BIBW an oral irreversible dual EGFR/HER2 inhibitor, in non-small cell lung cancer with mutated EGFR. World Lung Cancer Congress. Seoul. 2992, D7-02. Google Scholar
Erlichman C, Hidalgo M, Boni JP, Martins P, Quinn SE, Zacharchuk C, Amorusi P, Adjei AA, Rowinsky EK: Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors. J Clin Oncol. 2006, 24: 2252-2260. 10.1200/JCO.2005.01.8960. ArticleCASPubMed Google Scholar
Harari D, Yarden Y: Molecular mechanisms underlying ErbB2/HER2 action in breast cancer. Oncogene. 2000, 19: 6102-6114. 10.1038/sj.onc.1203973. ArticleCASPubMed Google Scholar
Mounawar M, Mukeria A, Le Calvez F, Hung RJ, Renard H, Cortot A, Bollart C, Zaridze D, Brennan P, Boffetta P, Brambilla E, Hainaut P: Patterns of EGFR, HER2, TP53, and KRAS mutations of p14arf expression in non-small cell lung cancers in relation to smoking history. Cancer Res. 2007, 67: 5667-5672. 10.1158/0008-5472.CAN-06-4229. ArticleCASPubMed Google Scholar
Cohen EE, Lingen MW, Martin LE, Harris PL, Brannigan BW, Haserlat SM, Okimoto RA, Sgroi DC, Dahiya S, Muir B, Clark JR, Rocco JW, Vokes EE, Haber DA, Bell DW: Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR. Clin Cancer Res. 2005, 11: 8105-8108. 10.1158/1078-0432.CCR-05-0926. ArticleCASPubMed Google Scholar
Shigematsu H, Takahashi T, Nomura M, Majmudar K, Suzuki M, Lee H, Wistuba II, Fong KM, Toyooka S, Shimizu N, Fujisawa T, Minna JD, Gazdar AF: Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res. 2005, 65: 1642-1646. 10.1158/0008-5472.CAN-04-4235. ArticleCASPubMed Google Scholar
Zinner RG, Glisson BS, Fossella FV, Pisters KM, Kies MS, Lee PM, Massarelli E, Sabloff B, Fritsche HA, Ro JY, Ordonez NG, Tran HT, Yang Y, Smith TL, Mass RD, Herbst RS: Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpressing disease. Lung Cancer. 2004, 44: 99-110. 10.1016/j.lungcan.2003.09.026. ArticlePubMed Google Scholar
Langer CJ, Stephenson P, Thor A, Vangel M, Johnson DH, Eastern Cooperative Oncology Group Study 2598: Trastuzumab in the treatment of advanced non-small-cell lung cancer: is there a role? Focus on Eastern Cooperative Oncology Group study 2598. J Clin Oncol. 2004, 22: 1180-1187. 10.1200/JCO.2004.04.105. ArticleCASPubMed Google Scholar
Gatzemeier U, Groth G, Butts C, Van Zandwijk N, Shepherd F, Ardizzoni A, Barton C, Ghahramani P, Hirsh V: Randomized phase II trial of gemcitabine-cisplatin with or without trastuzumab in Her2-positive non-small-cell lung cancer. Ann Oncol. 2004, 15: 19-27. 10.1093/annonc/mdh031. ArticleCASPubMed Google Scholar
Clamon G, Herndon J, Kern J, Govindan R, Garst J, Watson D, Green M, Cancer and Leukemia Group B: Lack of trastuzumab activity in non-small-cell lung carcinoma with overexpression of erb-B2: 39810: a phase II trial of Cancer and Leukemia Group B. Cancer. 2005, 103: 1670-1675. 10.1002/cncr.20950. ArticleCASPubMed Google Scholar
Besse B, Ropert S, Soria JC: Targeted therapies in lung cancer. Annals Onc. 2007, 18: 135-142. Article Google Scholar
Janne PA, Schellens JH, Engelman JA, Eckhardt SG, Millham R, Denis LJ, Britten CD, Wong SG, Boss DS, Camidge DR: Preliminary activity and safety results from a phase I clinical trial of PF-00299804, an irreversible pan-HER inhibitor, in patients (pts) with NSCLC [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 8027- Google Scholar
Balsara BR, Pei J, Mitsuuchi Y, Page R, Klein-Szanto A, Wang H, Unger M, Testa JR: Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis. 2004, 25: 2053-2059. 10.1093/carcin/bgh226. ArticleCASPubMed Google Scholar
Bjornsti MA, Houghton PJ: The TOR pathway: a target for cancer therapy. Nature Rev Cancer. 2004, 4: 335-348. 10.1038/nrc1362. ArticleCAS Google Scholar
Gridelli C, Maione P, Rossi A: The potential role of mTOR inhibitors in non-small cell lung cancer. Oncologist. 2008, 13: 139-147. 10.1634/theoncologist.2007-0171. ArticleCASPubMed Google Scholar
Molina JR, Mandrekar SJ, Rowland K, Reuter NF, Jett JR, Marks R, Schild SE, Adjei A: A phase II NCCTG "window of opportunity front-line" study of the mTOR inhibitor, CCI-779 (temosirolimus) given as a single agent in patients with advanced NSCLC. J Thorac Oncol. 2007, 2 (suppl 4): S413-10.1097/01.JTO.0000283298.56701.a0. Article Google Scholar
Papadimitrakopoulou V, Soria JC, Douillard JY, Giaccone G, Wolf J, Crino L, Cappuzzo F, Sharma S, Gross SH, Shepherd FA: A phase II study of RAD001 (r) (everolimus) monotherapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) failing prior platinum-based chemotherapy (c) or prior c and EGFR inhibitors (EGFR-I) [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7589- Google Scholar
Di Cosimo S, Matar P, Rojo F, Guzman M, Rodriguez S, Jimenez J, Arribas J, Cognetti F, Lane H, Baselga J: Schedule-dependent effects of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus (RAD001) [abstract]. J Clin Oncol. 2004, 22 (Suppl 14): 3074- Google Scholar
Milton DT, Riely GJ, Azzoli CG, Gomez JE, Heelan RT, Kris MG, Krug LM, Pao W, Pizzo B, Rizvi NA, Miller VA: Phase 1 trial of everolimus and gefitinib in patients with advanced non small-cell lung cancer. Cancer. 2007, 110: 599-605. 10.1002/cncr.22816. ArticleCASPubMed Google Scholar
Papadimitrakopoulou V, Blumenschein GR, Leighl NB, Bennouna J, Soria JC, Burris HA, Dimitrijevic S, Kunz T, Di Scala L, Johnson BE: A phase I/II study investigating the combination of RAD001 (r) (everolimus) and erlotinib (e) as 2nd and 3rd line therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC) previously treated with chemotherapy I: phase I results [abstract]. J Clin Oncol. 2008, 26 (Suppl 15): 8051- Google Scholar
Kumar Pal S, Figlin RA, Keckamp KL: The role of targeting mammalian target of rapamycin in lung cancer. Clin Lung Cancer. 2008, 9: 340-345. 10.3816/CLC.2008.n.049. ArticleCAS Google Scholar
Ferrara N: VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer. 2002, 2: 795-803. 10.1038/nrc909. ArticleCASPubMed Google Scholar
Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005, 23: 1011-27. 10.1200/JCO.2005.06.081. ArticleCASPubMed Google Scholar
Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M: Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family. Oncogene. 1990, 5: 519-524. CASPubMed Google Scholar
Terman B: Identification of a new endothelial cell growth factor receptor tyrosine kinase. Oncogene. 1991, 6: 1677-1683. CASPubMed Google Scholar
Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K: Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol. 2000, 156: 1499-1504. ArticlePubMed CentralCASPubMed Google Scholar
Hiratsuka S, Maru Y, Okada A, Seiki M, Noda T, Shibuya M: Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis. Cancer Res. 2001, 61: 1207-1213. CASPubMed Google Scholar
Fong GH, Rossant J, Gertsenstein M, Breitman ML: Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995, 376: 66-70. 10.1038/376066a0. ArticleCASPubMed Google Scholar
Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M: Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA. 1998, 95: 9349-9354. 10.1073/pnas.95.16.9349. ArticlePubMed CentralCASPubMed Google Scholar
Price DJ, Miralem T, Jiang S, Steinberg R, Avraham H: Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ. 2001, 12: 129-135. CASPubMed Google Scholar
Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM: Expression and function of vascular endothelial growth factor receptor 1 on human colorectal cancer cells. Oncogene. 2005, 24: 2647-2653. 10.1038/sj.onc.1208246. ArticleCASPubMed Google Scholar
Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT, Chung DC, Sahani DV, Kalva SP, Kozin SV, Mino M, Cohen KS, Scadden DT, Hartford AC, Fischman AJ, Clark JW, Ryan DP, Zhu AX, Blaszkowsky LS, Chen HX, Shellito PC, Lauwers GY, Jain RK: Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004, 10: 145-147. 10.1038/nm988. ArticlePubMed CentralCASPubMed Google Scholar
Jain RK: Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005, 307: 58-62. 10.1126/science.1104819. ArticleCASPubMed Google Scholar
Jain RK, Munn LL: Vascular normalization as a rationale for combining chemotherapy with antiangiogenesis agents. Principles and Practice of Oncology Updates. 2007, 21: 1-7. Google Scholar
Verheul HM, Lolkema MP, Qian DZ, Hilkes YH, Liapi E, Akkerman JW, Pili R, Voest EE: Platelets take up the monoclonal antibody bevacizumab. Clin Cancer Res. 2007, 13: 5341-10.1158/1078-0432.CCR-07-0847. ArticleCASPubMed Google Scholar
Sandler A, Gray R, Perry MC, Brahmer J, Schiller JH, Dowlati A, Lilenbaum R, Johnson DH: Paclitaxel-carboplatin alone or with bevacizumab for non-small cell lung cancer. N Engl J Med. 2006, 355: 2542-2540. 10.1056/NEJMoa061884. ArticleCASPubMed Google Scholar
Manegold C, von Pawel J, Zatloukal P, Ramlau R, Gorbounova V, Hirsch V, Leighl N, Mezger J, Archer V, Reck M, the BO17704 study group: Randomized, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naïve patients with advanced or recurrent non-squamous no-small cell lung cancer (NSCLC): BO17704 [abstract]. J Clin Oncol. 2007, 25: 967s- Google Scholar
Reck M, von Pawel J, Zatlouka P, Ramlau R, Gorbounova V, Hirsh V, Leighl N, Mezger J, Archer V, Manegold C: First-line bevacizumab combined with cisplatin/gemcitabine (CG) in patients (PTS) with advanced non-small cell lung cancer (NSCLC): AVAIL (BO17704), a phase III randomized study. Chicago Multidisciplinary symposium in thoracic oncology 2008: 13–15 November 2008; Chicago. 2008, 101- Google Scholar
Reily GJ, Miller VA: Vascular endothelial growth factor trap in non-small cell lung cancer. Clin Cancer Res. 2007, 13: 4623s-4626s. 10.1158/1078-0432.CCR-07-0544. ArticleCAS Google Scholar
Massarelli E, Miller VA, Leighl NB, Rosen PJ, Albain KS, Hart LL, Melnyk O, Sternas L, Ackerman J, Herbst RS: Phase II study of the efficacy and safety of intravenous (iv) AVE0005 (VEGF Trap) given every 2 weeks in patients (pts) with platinum- and erlotinib-resistant adenocarcinoma of the lung (NSCLC) [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7627- Google Scholar
Aita M, Fasola G, Defferrari C, Brianti A, Bello MG, Follador A, Sinaccio G, Pronzato P, Grossi F: Targeting the VEGF pathway: antiangiogenic strategies in the treatment of non-small cell lung cancer. Crit Rev Oncol Hematol. 2008, 68: 183-196. 10.1016/j.critrevonc.2008.05.002. ArticlePubMed Google Scholar
Hida T, Kozaki K, Muramatsu H, Masuda A, Shimizu S, Mitsudomi T, Sugiura T, Ogawa M, Takahashi T: Cyclooxygenase-2 inhibitor induces apoptosis and enhances cytotoxicity of various anticancer agents in non-small cell lung cancer cell lines. Clin Cancer Res. 2000, 6: 2006-2011. CASPubMed Google Scholar
Lilenbaum R, Socinski MA, Altorki NK, Hart LL, Keresztes RS, Hariharan S, Morrison ME, Fayyad R, Bonomi P: Randomized phase II trial of docetaxel/irinotecan and gemcitabine/irinotecan with or without celecoxib in the second-line treatment of non-small-cell lung cancer. J Clin Oncol. 2006, 24: 4825-10.1200/JCO.2006.07.4773. ArticleCASPubMed Google Scholar
Scagliotti GV, Novello S, Brahmer J, Govindan R, Rosell R, Belani C, Atkins J, Tye L, Chao R, Socinski MA: A phase II study of continuous daily sunitinib dosing in patients with previously-treated advanced non-small cell lung cancer (NSCLC). 12th World Conference on Lung Cancer, Seoul, Korea, September 2–6, 2007. J Thorac Oncol. 2007, 2 (Suppl 4): S470-10.1097/01.JTO.0000283418.42111.77. Article Google Scholar
Socinski MA: Current status and evolving role of sunitinib in non-small cell lung cancer. J Thorac Oncol. 2008, 3 (suppl 2): S119-S123. ArticlePubMed Google Scholar
Robert F, Sandler A, Schiller JH, Ilagan J, VerMeulen W, Harper K, Liu G, Tye L, Chao R, Traynor A: A phase I dose-escalation and pharmacokinetic (PK) study of sunitinib (SU) plus docetaxel (D) in patients (pts) with advanced solid tumors (STs) [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 3543- Google Scholar
Gatzemeier U, Blumenschein G, Fosella F, Simantov R, Elting J, Bigwood D, Cihon F, Reck M: Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma [abstract]. J Clin Oncol. 2006, 24 (Suppl 18): 7002- Google Scholar
Schiller JH, Flaherty KT, Redlinger M, Binger K, Eun J, Petrenciuc O, O'Dwyer P: Sorafenib combined with carboplatin/paclitaxel for advanced non-small cell lung cancer: A phase I subset analysis [abstract]. J Clin Oncol. 2006, 24 (Suppl 18): 7194- Google Scholar
Adjei AA, Molina JR, Hillman SL, Luyun RF, Reuter NF, Rowland KM, Jett JR, Mandrekar SJ, Schild SE: A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: a north central cancer treatment group study [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7547- Google Scholar
Blumenschein G: Sorafenib in lung cancer: clinical developments and future directions. J Thorac Oncol. 2008, 3 (suppl 2): S124-S127. ArticlePubMed Google Scholar
Heymach JV, Johnson BE, Prager D, Csada E, Roubec J, Pesek M, Spásová I, Belani CP, Bodrogi I, Gadgeel S, Kennedy SJ, Hou J, Herbst RS: Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol. 2007, 25: 4270-4277. 10.1200/JCO.2006.10.5122. ArticleCASPubMed Google Scholar
Schiller JH, Larson T, Ou SI, Limentani SA, Sandler AB, Vokes EE, Kim S, Liau KF, Bycott PW, Olszanski AJ: Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase II trial [abstract]. J Clin Oncol. 2007, 25 (Suppl 18): 7507- Google Scholar
Fanucchi MP, Fossella FV, Belt R, Natale R, Fidias P, Carbone DP, Govindan R, Raez LE, Robert F, Ribeiro M, Akerley W, Kelly K, Limentani SA, Crawford J, Reimers HJ, Axelrod R, Kashala O, Sheng S, Schiller JH: Randomized phase II study of bortezomib alone and bortezomib in combination with docetaxel in previously treated advanced non-small-cell lung cancer. J Clin Oncol. 2006, 24: 5025-5033. 10.1200/JCO.2006.06.1853. ArticleCASPubMed Google Scholar
Davies AM, McCoy J, Lara PN, Gumerlock PH, Crowley J, Gandara DR, Southwest Oncology Group Thoracic Committee: Bortezomib + gemcitabine (gem)/carboplatin (carbo) results in encouraging survival in advanced non-small cell lung cancer (NSCLC): results of a phase II southwest oncology group (SWOG) trial (S0339)[abstract]. J Clin Oncol. 2006, 24 (Suppl 18): 7017- Google Scholar
Davies AM, Lara PN, Mack PC, Gandara DR: Incorporating bortezomib into the treatment of lung cancer. Clin Cancer Res. 2007, 13 (Suppl 15): 4647s-4651s. 10.1158/1078-0432.CCR-07-0334. ArticleCAS Google Scholar
Xu XC, Sozzi G, Lee JS, Lee JJ, Pastorino U, Pilotti S, Kurie JM, Hong WK, Lotan R: Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: Implications for lung cancer development. J Natl Cancer Inst. 1997, 89: 624-629. 10.1093/jnci/89.9.624. ArticleCASPubMed Google Scholar
Houle B, Rochette-Egly C, Bradley WE: Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells. Proc Natl Acad Sci USA. 1993, 90: 985-989. 10.1073/pnas.90.3.985. ArticlePubMed CentralCASPubMed Google Scholar
Blumenschein GR, Khuri FR, von Pawel J, Gatzemeier U, Miller WH, Jotte RM, Le Treut J, Sun SL, Zhang JK, Dziewanowska ZE, Negro-Vilar A: Phase III trial comparing carboplatin, paclitaxel, and bexarotene with carboplatin and paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT II. J Clin Oncol. 2008, 26: 1879-1885. 10.1200/JCO.2007.12.2689. ArticleCASPubMed Google Scholar
Ramlau R, Zatloukal P, Jassem J, Schwarzenberger P, Orlov SV, Gottfried M, Pereira JR, Temperley G, Negro-Vilar R, Rahal S, Zhang JK, Negro-Vilar A, Dziewanowska ZE: Randomized phase III trial comparing bexarotene (L1069-49)/cisplatin/vinorelbine with cisplatin/vinorelbine in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT I. J Clin Oncol. 2008, 26: 1886-1892. 10.1200/JCO.2007.12.2614. ArticleCASPubMed Google Scholar