Four Core Genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels (original) (raw)
De Vries GJ, Rissman EF, Simerly RB, Yang LY, Scordalakes EM, Auger CJ, et al. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci. 2002;22:9005–14. PubMed Google Scholar
Arnold AP, Burgoyne PS. Are XX and XY brain cells intrinsically different? Trends Endocrinol Metab. 2004;15:6–11. ArticleCASPubMed Google Scholar
Arnold AP. The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues. Horm Behav. 2009;55:570–8. ArticlePubMed CentralCASPubMed Google Scholar
Arnold AP. Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues. J Neuroendocrinol. 2009;21:377–86. ArticlePubMed CentralCASPubMed Google Scholar
Arnold AP, Chen X. What does the "four core genotypes" mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol. 2009;30:1–9. ArticlePubMed CentralPubMed Google Scholar
Cox KH, Bonthuis PJ, Rissman EF. Mouse model systems to study sex chromosome genes and behavior: Relevance to humans. Front Neuroendocrinol. 2014;35:405–19. ArticleCASPubMed Google Scholar
Lovell-Badge R, Robertson E. XY female mice resulting from a heritable mutation in the primary testis-determining gene. Tdy Dev. 1990;109:635–46. CAS Google Scholar
Mahadevaiah SK, Odorisio T, Elliott DJ, Rattigan A, Szot M, Laval SH, et al. Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities. Hum Mol Genet. 1998;7:715–27. ArticleCASPubMed Google Scholar
Abel JM, Witt DM, Rissman EF. Sex differences in the cerebellum and frontal cortex: roles of estrogen receptor alpha and sex chromosome genes. Neuroendocrinol. 2011;93:230–40. ArticleCAS Google Scholar
Markham JA, Jurgens HA, Auger CJ, De Vries GJ, Arnold AP, Juraska JM. Sex differences in mouse cortical thickness are independent of the complement of sex chromosomes. Neurosci. 2003;116:71–5. ArticleCAS Google Scholar
Barker JM, Torregrossa MM, Arnold AP, Taylor JR. Dissociation of genetic and hormonal influences on sex differences in alcoholism-related behaviors. J Neurosci. 2010;30:9140–4. ArticlePubMed CentralCASPubMed Google Scholar
Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Rattigan A, et al. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001;29:49–53. ArticleCASPubMed Google Scholar
Bonthuis PJ, Cox KH, Rissman EF. X-chromosome dosage affects male sexual behavior. Horm Behav. 2012;64:565–72. Article Google Scholar
McPhie-Lalmansingh AA, Tejada LD, Weaver JL, Rissman EF. Sex chromosome complement affects social interactions in mice. Horm Behav. 2008;54:565–70. ArticlePubMed CentralPubMed Google Scholar
Burgoyne PS, Ojarikre OA, Turner JM. Evidence that postnatal growth retardation in XO mice is due to haploinsufficiency for a non-PAR X gene. Cytogenet Genome Res. 2002;99:252–6. ArticleCASPubMed Google Scholar
Moore S, Patel R, Hannsun G, Yang J, Tiwari-Woodruff SK. Sex chromosome complement influences functional callosal myelination. Neurosci. 2013;245:166–78. ArticleCAS Google Scholar
Caeiro XE, Mir FR, Vivas LM, Carrer HF, Cambiasso MJ. Sex chromosome complement contributes to sex differences in bradycardic baroreflex response. Hypertension. 2011;58:505–11. ArticleCASPubMed Google Scholar
Ngun TC, Ghahramani NM, Creek MM, Williams-Burris SM, Barseghyan H, Itoh Y, et al. Feminized behavior and brain gene expression in a novel mouse model of Klinefelter Syndrome. Arch Sex Behav. 2014;43:1043–57. ArticlePubMed Google Scholar
Carruth LL, Reisert I, Arnold AP. Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci. 2002;5:933–4. ArticleCASPubMed Google Scholar
Palaszynski KM, Smith DL, Kamrava S, Burgoyne PS, Arnold AP, Voskuhl RR. A Yin-Yang effect between sex chromosome complement and sex hormones on the immune response. Endocrinol. 2005;146:3280–5. ArticleCAS Google Scholar
Chen X, Watkins R, Delot E, Reliene R, Schiestl RH, Burgoyne PS, et al. Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol. 2008;68:265–73. ArticleCASPubMed Google Scholar
Chen X, Grisham W, Arnold AP. X chromosome number causes sex differences in gene expression in adult mouse striatum. Eur J Neurosci. 2009;29:768–76. ArticlePubMed Google Scholar
Chen X, McClusky R, Chen J, Beaven SW, Tontonoz P, Arnold AP, et al. The number of X chromosomes causes sex differences in adiposity in mice. PLoS Genet. 2012;8:e1002709. ArticlePubMed CentralCASPubMed Google Scholar
Chen X, McClusky R, Itoh Y, Reue K, Arnold AP. X and Y chromosome complement influence adiposity and metabolism in mice. Endocrinol. 2013;154:1092–104. ArticleCAS Google Scholar
Chen X, Williams-Burris SM, McClusky R, Ngun TC, Ghahramani N, Barseghyan H, et al. The Sex Chromosome Trisomy mouse model of XXY and XYY: metabolism and motor performance. Biol Sex Differ. 2013;4:15. ArticlePubMed CentralPubMed Google Scholar
Park JH, Burns-Cusato M, Dominguez-Salazar E, Riggan A, Shetty S, Arnold AP, et al. Effects of sex chromosome aneuploidy on male sexual behavior. Genes Brain Behav. 2008;7:609–17. ArticlePubMed CentralCASPubMed Google Scholar
Cocquet J, Ellis PJ, Yamauchi Y, Mahadevaiah SK, Affara NA, Ward MA, et al. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244. ArticlePubMed CentralPubMed Google Scholar
Quinn JJ, Hitchcott PK, Umeda EA, Arnold AP, Taylor JR. Sex chromosome complement regulates habit formation. Nat Neurosci. 2007;10:1398–400. ArticleCASPubMed Google Scholar
Corre C, Friedel M, Vousden DA, Metcalf A, Spring S, Qiu LR, et al. Separate effects of sex hormones and sex chromosomes on brain structure and function revealed by high-resolution magnetic resonance imaging and spatial navigation assessment of the Four Core Genotype mouse model**.** Brain Struct Funct. 2014;epub Dec 2.
Reynard LN, Cocquet J, Burgoyne PS. The multi-copy mouse gene Sycp3-like Y-linked (Sly) encodes an abundant spermatid protein that interacts with a histone acetyltransferase and an acrosomal protein. Biol Reprod. 2009;81:250–7. ArticlePubMed CentralCASPubMed Google Scholar
Cox KH, Rissman EF. Sex differences in juvenile mouse social behavior are influenced by sex chromosomes and social context. Genes Brain Behav. 2011;10:465–72. ArticlePubMed CentralCASPubMed Google Scholar
Robinson DP, Huber SA, Moussawi M, Roberts B, Teuscher C, Watkins R, et al. Sex chromosome complement contributes to sex differences in Coxsackievirus B3 but not Influenza A virus pathogenesis. Biol Sex Differ. 2011;2:8. ArticlePubMed CentralPubMed Google Scholar
Dadam FM, Caeiro XE, Cisternas CD, Macchione AF, Cambiasso MJ, Vivas L. Effect of sex chromosome complement on sodium appetite and Fos-immunoreactivity induced by sodium depletion. Am J Physiol Regul Integr Comp Physiol. 2014;306:R175–84. ArticleCASPubMed Google Scholar
Sasidhar MV, Itoh N, Gold SM, Lawson GW, Voskuhl RR. The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY. Ann Rheum Dis. 2012;71:1418–22. ArticleCASPubMed Google Scholar
Scerbo MJ, Freire-Regatillo A, Cisternas CD, Brunotto M, Arevalo MA, Garcia-Segura LM, et al. Neurogenin 3 mediates sex chromosome effects on the generation of sex differences in hypothalamic neuronal development. Front Cell Neurosci. 2014;8:188. ArticlePubMed CentralPubMed Google Scholar
Durcova-Hills G, Burgoyne P, McLaren A. Analysis of sex differences in EGC imprinting. Dev Biol. 2004;268:105–10. ArticleCASPubMed Google Scholar
Seney ML, Ekong KI, Ding Y, Tseng GC, Sibille E. Sex chromosome complement regulates expression of mood-related genes. Biol Sex Differ. 2013;4:20. ArticlePubMed CentralPubMed Google Scholar
Seney ML, Chang LC, Oh H, Wang X, Tseng GC, Lewis DA, et al. The role of genetic sex in affect regulation and expression of GABA-related enes across species. Front Psychiatry. 2013;4:104. ArticlePubMed CentralPubMed Google Scholar
Ehlen JC, Hesse S, Pinckney L, Paul KN. Sex chromosomes regulate nighttime sleep propensity during recovery from sleep loss in mice. PLoS ONE. 2013;8:e62205. ArticlePubMed CentralCASPubMed Google Scholar
Seu E, Groman SM, Arnold AP, Jentsch JD. Sex chromosome complement influences operant responding for a palatable food in mice. Genes Brain Behav. 2014;13:527–34. ArticleCASPubMed Google Scholar
Ellis PJ, Clemente EJ, Ball P, Toure A, Ferguson L, Turner JM, et al. Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids. Hum Mol Genet. 2005;14:2705–15. ArticleCASPubMed Google Scholar
Smith-Bouvier DL, Divekar AA, Sasidhar M, Du S, Tiwari-Woodruff SK, King JK, et al. A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med. 2008;205:1099–108. ArticlePubMed CentralCASPubMed Google Scholar
Gatewood JD, Wills A, Shetty S, Xu J, Arnold AP, Burgoyne PS, et al. Sex chromosome complement and gonadal sex influence aggressive and parental behaviors in mice. J Neurosci. 2006;26:2335–42. ArticleCASPubMed Google Scholar
Szot M, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Toure A. von GE et al. Does Rbmy have a role in sperm development in mice? Cytogenet Genome Res. 2003;103:330–6. ArticleCASPubMed Google Scholar
Gioiosa L, Chen X, Watkins R, Klanfer N, Bryant CD, Evans CJ, et al. Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice. Horm Behav. 2008;53:124–30. ArticlePubMed CentralCASPubMed Google Scholar
Gioiosa L, Chen X, Watkins R, Umeda EA, Arnold AP. Sex chromosome complement affects nociception and analgesia in newborn mice. J Pain. 2008;9:962–9. ArticlePubMed CentralPubMed Google Scholar
Toure A, Szot M, Mahadevaiah SK, Rattigan A, Ojarikre OA, Burgoyne PS. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics. 2004;166:901–12. ArticlePubMed CentralCASPubMed Google Scholar
Toure A, Clemente EJ, Ellis P, Mahadevaiah SK, Ojarikre OA, Ball PA, et al. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biol. 2005;6:R102. ArticlePubMed CentralPubMed Google Scholar
Ishikawa H, Rattigan A, Fundele R, Burgoyne PS. Effects of sex chromosome dosage on placental size in mice. Biol Reprod. 2003;69:483–8. ArticleCASPubMed Google Scholar
Van Nas A, GuhaThakurta D, Wang SS, Yehya N, Horvath S, Zhang B, et al. Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinol. 2009;150:1235–49. Article Google Scholar
Ji H, Zheng W, Wu X, Liu J, Ecelbarger CM, Watkins R, et al. Sex chromosome effects unmasked in angiotensin II-induced hypertension. Hypertension. 2010;55:1275–82. ArticlePubMed CentralCASPubMed Google Scholar
Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, et al. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011;21:787–93. ArticlePubMed CentralCASPubMed Google Scholar
Vernet N, Mahadevaiah SK, Ellis PJ, de Rooij DG, Burgoyne PS. Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis. Reproduction. 2012;144:433–45. ArticlePubMed CentralCASPubMed Google Scholar
Kopsida E, Lynn PM, Humby T, Wilkinson LS, Davies W. Dissociable effects of Sry and sex chromosome complement on activity, feeding and anxiety-related behaviours in mice. PLoS ONE. 2013;8:e73699. ArticlePubMed CentralCASPubMed Google Scholar
Wagner CK, Xu J, Pfau JL, Quadros PS, De Vries GJ, Arnold AP. Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status. Endocrinol. 2004;145:1046–9. ArticleCAS Google Scholar
Kuljis DA, Loh DH, Truong D, Vosko AM, Ong ML, McClusky R, et al. Gonadal- and sex-chromosome-dependent sex differences in the circadian system. Endocrinol. 2013;154:1501–12. ArticleCAS Google Scholar
Ward MA, Burgoyne PS. The effects of deletions of the mouse Y chromosome long arm on sperm function–intracytoplasmic sperm injection (ICSI)-based analysis. Biol Reprod. 2006;74:652–8. ArticleCASPubMed Google Scholar
Kuo J, Hamid N, Bondar G, Dewing P, Clarkson J, Micevych P. Sex differences in hypothalamic astrocyte response to estradiol stimulation. Biol Sex Differ. 2010;1:7. ArticlePubMed CentralCASPubMed Google Scholar
Wijchers PJ, Yandim C, Panousopoulou E, Ahmad M, Harker N, Saveliev A, et al. Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well. Dev Cell. 2010;19:477–84. ArticleCASPubMed Google Scholar
Li J, Chen X, McClusky R, Ruiz-Sundstrom M, Itoh Y, Umar S, et al. The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two. Cardiovasc Res. 2014;102:375–94. ArticleCASPubMed Google Scholar
Xu J, Arnold AP. Sexually dimorphic expression of co-repressor Sin3A in mouse kidneys. Endocr Res. 2005;31:111–9. ArticleCASPubMed Google Scholar
Liu J, Ji H, Zheng W, Wu X, Zhu JJ, Arnold AP, et al. Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17beta-oestradiol-dependent and sex chromosome-independent. Biol Sex Differ. 2010;1:6. ArticlePubMed CentralCASPubMed Google Scholar
Xu J, Deng X, Watkins R, Disteche CM. Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons. J Neurosci. 2008;28:4521–7. ArticlePubMed CentralCASPubMed Google Scholar
Xu J, Deng X, Disteche CM. Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain. PLoS One. 2008;3:e2553. ArticlePubMed CentralPubMed Google Scholar
Xu J, Burgoyne PS, Arnold AP. Sex differences in sex chromosome gene expression in mouse brain. Hum Mol Genet. 2002;11:1409–19. ArticleCASPubMed Google Scholar
Xu J, Taya S, Kaibuchi K, Arnold AP. Sexually dimorphic expression of Usp9x is related to sex chromosome complement in adult mouse brain. Eur J Neurosci. 2005;21:3017–22. ArticleCASPubMed Google Scholar
Xu J, Taya S, Kaibuchi K, Arnold AP. Spatially and temporally specific expression in mouse hippocampus of Usp9x, a ubiquitin-specific protease involved in synaptic development. J Neurosci Res. 2005;80:47–55. ArticleCASPubMed Google Scholar
Xu J, Watkins R, Arnold AP. Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain. Gene Expr Patterns. 2006;6:146–55. ArticleCASPubMed Google Scholar
Yamauchi Y, Riel JM, Stoytcheva Z, Burgoyne PS, Ward MA. Deficiency in mouse Y chromosome long arm gene complement is associated with sperm DNA damage. Genome Biol. 2010;11:R66. ArticlePubMed CentralPubMed Google Scholar
Manwani B, Bentivegna K, Benashski SE, Venna VR, Xu Y, Arnold AP, et al. Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement. J Cereb Blood Flow Metab. 2015;35:221–9. ArticleCASPubMed Google Scholar
Schneider JE, Wysocki CJ, Nygy J, Whitney G. Determining the sex of neonatal mice (Mus musculus). Behav Res Methods Instrum. 1978;10:105. Article Google Scholar
Hotchkiss AK, Vandenbergh JG. The anogenital distance index of mice (Mus musculus domesticus): an analysis. Contemp Top Lab Anim Sci. 2005;44:46–8. CASPubMed Google Scholar
Ninomiya T, Iwabuchi T, Soga Y, Yuki A. Direct sequencing of flanking regions of a transgene amplified by inverted PCR. Agric Biol Chem. 1990;54:1869–72. ArticleCASPubMed Google Scholar
Arnold C, Hodgson IJ. Vectorette PCR: a novel approach to genomic walking. PCR Methods Appl. 1991;1:39–42. ArticleCASPubMed Google Scholar
Benjamini Y, Drai D, Elmer G, Kafkafi N, Golani I. Controlling the false discovery rate in behavior genetics research. Behav Brain Res. 2001;125:279–84. ArticleCASPubMed Google Scholar
Du S, Itoh N, Askarinam S, Hill H, Arnold AP, Voskuhl RR. XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2014;111:2806–11. ArticlePubMed CentralCASPubMed Google Scholar