Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice (original) (raw)

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Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

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Argentina

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Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

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Argentina

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Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

,

Argentina

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Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

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Argentina

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Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

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Argentina

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María C Pistoresi-Palencia

Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba

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Argentina

Correspondence: Departamento de Bioquímica Clínica, CIBICI (CONICET), Facultad de Ciencias Químicas, UNC, Haya de la Torre y Medina Allende, Ciudad Universitaria, (5000) Córdoba, Argentina. E-mail: cpistore@bioclin.fcq.unc.edu.ar

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Revision received:

10 February 2005

Accepted:

11 February 2005

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Diego Alignani, Belkys Maletto, Miriam Liscovsky, Andrea Rópolo, Gabriel Morón, María C Pistoresi-Palencia, Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice, Journal of Leukocyte Biology, Volume 77, Issue 6, Jun 2005, Pages 898–905, https://doi.org/10.1189/jlb.0604330
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Abstract

We have previously demonstrated that subcutaneously administered ovalbumin (OVA) plus synthetic oligodeoxynucleotides containing immunostimulatory CpG motifs (CpG-ODN) as adjuvant stimulate cellular and humoral immunity and promote T helper cell type 1 differentiation in aged mice. The present study assessed the ability of CpG-ODN to induce an OVA-specific immune response after oral immunization in young (3-month-old) and aged (18-month-old) BALB/c mice. Oral OVA/CpG-ODN immunization induces a similar OVA-specific T cell-proliferative response (in mucosal and systemic tissues), immunoglobulin G (IgG) in plasma, and IgA in intestinal washes in both groups of ages. The OVA-specific humoral immune response observed in aged mice was similar to the one observed in young mice, peaking at day 7 after the last oral immunization and was present over 40 days after the last oral immunization. The pattern of cytokines released in culture supernatants in both groups of mice was similar, with specific interferon-γ secretion in the absence of interleukin-5 responses. These results provide evidence that orally administered OVA/CpG-ODN induces a young-like, specific, immune response against OVA in aged mice, showing that CpG-ODN might be used as a mucosal adjuvant during aging.

© 2005 Society for Leukocyte Biology

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