Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 (original) (raw)

Journal Article

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Department of Pathology, Stanford University School of Medicine

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Stanford, California

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USA

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Center for Experimental Medicine, Institute of Medical Science, University of Tokyo

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Tokyo

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Japan

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Department of Pathology, Stanford University School of Medicine

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Stanford, California

,

USA

Atopy Research Center, Juntendo University

,

Tokyo

,

Japan

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Department of Pathology, Stanford University School of Medicine

,

Stanford, California

,

USA

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Received:

03 October 2006

Revision received:

29 November 2006

Accepted:

10 January 2007

Published:

16 February 2007

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Susumu Nakae, Yoichiro Iwakura, Hajime Suto, Stephen J Galli, Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17, Journal of Leukocyte Biology, Volume 81, Issue 5, May 2007, Pages 1258–1268, https://doi.org/10.1189/jlb.1006610
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Abstract

Recent evidence fromseveral groups indicates that IL-17-producing Th17 cells, rather than, as once was thought, IFN-γ-producing Th1 cells, can represent the key effector cells in the induction/development of several autoimmune and allergic disorders. Although Th17 cells exhibit certain phenotypic and developmental differences from Th1 cells, the extent of the differences between these two T cell subsets is still not fully understood. We found that the expression profile of cell surface molecules on Th17 cells has more similarities to that of Th1 cells than Th2 cells. However, although certain Th1-lineage markers [i.e., IL-18 receptor α, CXCR3, and T cell Ig domain, mucin-like domain-3 (TIM-3)], but not Th2-lineage markers (i.e., T1/ST2, TIM-1, and TIM-2), were expressed on Th17 cells, the intensity of expression was different between Th17 and Th1 cells. Moreover, the expression of CTLA-1, ICOS, programmed death ligand 1, CD153, Fas, and TNF-related activation-induced cytokine was greater on Th17 cells than on Th1 cells. We found that IL-23 or IL-17 can suppress Th1 cell differentiation in the presence of exogenous IL-12 in vitro. We also confirmed that IL-12 or IFN-γ can negatively regulate Th17 cell differentiation. However, these cytokines could not modulate such effects on T cell differentiation in the absence of APC.

© 2007 Society for Leukocyte Biology

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