Clinicopathological Studies of the Dementias from an Epidemiological Viewpoint | The British Journal of Psychiatry | Cambridge Core (original) (raw)

Abstract

Studies which examine patients with and without dementia during life and then examine brain tissue after death are extremely difficult to conduct. There are now several such studies published, representing a major contribution to the understanding of the pathologies of the dementias. These studies were not designed to represent population samples and, from an epidemiological viewpoint, they are flawed because none are population-based and none represent the full range of function observed during life. It is therefore important to examine the available studies for their contributions and biases.

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders . Washington, DC: APA.Google Scholar

Alafuzoff, I., Iqbal, K., Friden, H., (1987) Histopathological criteria for progressive dementia disorders: clinical–pathological correlation and classification by multivariate data analysis. Acta Neuropathologica, 74, 209–225.CrossRefGoogle ScholarPubMed

Beardsall, L., Barkley, C. & O'Sullivan, A. (1992) The response of elderly community residents to requests for brain donation: an interim report. International Journal of Geriatric Psychiatry, 7, 199–202.CrossRefGoogle Scholar

Blessed, G., Tomlinson, B.C. & Roth, M. (1968) The association between quantitative measures and degenerative changes in the cerebral gray matter of elderly patients. British Journal of Psychiatry, 114, 797–811.CrossRefGoogle Scholar

Boller, F., Lopez, O.L. & Moossy, J. (1989) Diagnosis of dementia: clinicopathologic correlations. Neurology, 39, 76–79.CrossRefGoogle ScholarPubMed

Brayne, C. (1990) A study of dementia in a rural population. MD Thesis: University of London.Google Scholar

Brayne, C. & Calloway, P. (1990) The case identification of dementia in the community: a comparison of methods. International Journal of Geriatric Psychiatry, 5, 309–316.CrossRefGoogle Scholar

Brayne, C., Huppert, F., Paykel, E., (1992) The Cambridge project for later life: design and preliminary results. European Studies on the Incidence of Dementing Diseases, vol. II (eds Launer, L. J., Brayne, C., Dartigues, J–F., ). pp. 71–75.Google Scholar

Brown, P., Goldfarb, L.G. & Gadjusek, D.C. (1991) The new biology of spongiform encephalopathy: infectious amyloidoses with a genetic twist. Lancet, 337, 1019–1022.CrossRefGoogle ScholarPubMed

Burns, A., Luthert, P., Levy, R., (1990) Accuracy of clinical diagnosis of Alzheimer's disease. British Medical Journal, 301, 1026.CrossRefGoogle ScholarPubMed

Burns, A., Levy, R. & Jacoby, R. (1991) Diagnosis of Alzheimer's disease. British Medical Journal, 302, 48.CrossRefGoogle Scholar

Byrne, E.J., Smith, C.W. & Arie, T. (1991) The diagnosis of dementia – I clinical and pathological criteria: a review of the literature. International Journal of Geriatric Psychiatry, 6, 199–208.CrossRefGoogle Scholar

Chadwick, C. (1992) The MRC multicentre study of cognitive function and ageing. European Studies on the Incidence of Dementing Diseases, vol. II (eds Launer, L. J., Brayne, C., Dartigues, J–F., ). , 37–43.Google Scholar

Cohen, J. (1960) A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37–46.CrossRefGoogle Scholar

Crystal, H., Dickson, D., Fuld, P., (1988) Clinico–pathological studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology, 38, 1682–1687.CrossRefGoogle Scholar

del Ser, T., Bermejo, F., Portera, A., (1990) Vascular dementia. A clinicopathological study. Journal of the Neurological Sciences, 96, 1–17.CrossRefGoogle ScholarPubMed

Duyckaerts, C., Delaere, P., Hauw, J.J., (1990) Rating of the lesions in senile dementia of the Alzheimer type: concordance between laboratories. A European multi–centre study under the auspices of EURAGE. Journal of Neurological Sciences, 97, 295–323.CrossRefGoogle Scholar

Esiri, M. (1992) Dementia and normal ageing: neuropathology. Dementia and Normal Ageing (eds Huppert, F., Brayne, C. & O'Connor, D.). Cambridge: Cambridge University Press.Google Scholar

Fazekas, F., Chawluk, J.B., Alavi, A., (1987) MR signal abnormalities at 1.5T in Alzheimer's dementia and normal aging. American Journal of Radiology, 149, 351–356.Google Scholar

Fox, J.H., Penn, R., Clasen, R., (1985) Pathological diagnosis in clinically typical Alzheimer's disease. New England Journal of Medicine, 313, 1419–1420.Google ScholarPubMed

Hodges, J. (1992) Pick's disease. Dementia (eds Burns, A. & Levy, R.). London: Chapman and Hall .Google ScholarPubMed

Holland, C.A. & Rabbitt, P. (1991) The course and causes of cognitive change with advancing age. Reviews in Clinical Gerontology, 1, 81–96.CrossRefGoogle Scholar

Homer, A., Honavar, M., Lantos, P., (1988) Diagnosing dementia: do we get it right? British Medical Journal, 297, 894–896.CrossRefGoogle ScholarPubMed

Houx, P.J., Vreeling, F.W. & Jolles, J. (1991) Rigorous health screening reduces age effect on memory scanning task. Brain and Cognition, 15, 246–260.CrossRefGoogle ScholarPubMed

Jellinger, K., Danielczyk, W., Fishcher, P., (1990) Clinicopathological analysis of dementia disorders in the elderly. Journal of the Neurological Sciences, 95, 239–258.CrossRefGoogle ScholarPubMed

Joachim, C.L., Morris, J.H. & Selkoe, D.J. (1988) Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Annals of Neurology, 24, 50–56.CrossRefGoogle ScholarPubMed

Katzman, R., Brown, T., Fuld, P., (1983) Validation of a short orientation–memory-concentration test of cognitive impairment. American Journal of Psychiatry, 140, 734–739.Google Scholar

Katzman, R., Brown, T., Fuld, P., (1986) Significance of neurotransmitter abnormalities in Alzheimer's disease. Research in Public Association Research Nervous and Mental Disorders, 64, 279–286.Google ScholarPubMed

Katzman, R., Terry, R., de Teresa, R., (1988) Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Annals of Neurology, 23, 138–144.CrossRefGoogle ScholarPubMed

Kay, E.W., Henderson, A.S., Scott, R., (1985) Dementia and depression among the elderly living in the Hobart community: the effect of the diagnostic criteria on the prevalence rates. Psychological Medicine, 15, 771–788.CrossRefGoogle ScholarPubMed

Kellett, J.M., Gilleard, C., Homer, A., (1991) Diagnosis of Alzheimer's disease. British Medical Journal, 302, 47.Google Scholar

Kretzschmer, H.A., Honold, G., Seitelberg, F., (1991) Prion protein mutation in family first reported by Gerstmann, Straeussler and Scheinker. Lancet, 337, 1160.CrossRefGoogle Scholar

Kukull, W.A., Larson, E.B., Reifler, B.V., (1990) Interrater reliability of Alzheimer's disease diagnosis. Neurology, 40, 257–260.CrossRefGoogle ScholarPubMed

Lindley, R.I. & Dennis, M.S. (1991) Diagnosis of Alzheimer's disease. British Medical Journal, 302, 47.CrossRefGoogle Scholar

Larson, E.B., Reifler, B.V., Sumi, S.M., (1986) Diagnostic tests in the evaluation of dementia: A prospective study of 200 elderly outpatients. Archives of Internal Medicine, 146, 1917–1922.CrossRefGoogle ScholarPubMed

Lennox, G., Lowe, J., Byrne, E.J., (1989) Diffuse lewy body disease. Lancet, i, 323–324.CrossRefGoogle Scholar

Little, A., Hemsley, D., Bergmann, K., (1987) Comparison of the sensitivity of three instruments for the detection of cognitive decline in the elderly living at home. British Journal of Psychiatry, 150, 808–814.CrossRefGoogle ScholarPubMed

Mann, D.M., Yates, P.O., Marcyniuk, B., (1987) Loss of neurones from cortical and subcortical areas in Down's syndrome patients at middle age. Quantitative comparisons with younger Down's patients and patients with Alzheimer's disease. Journal of the Neurological Sciences, 80, 79–89.CrossRefGoogle ScholarPubMed

Manning, F.C. (1991) Diagnosis of Alzheimer's disease. British Medical Journal, 302, 47–48.CrossRefGoogle Scholar

Martin, E.M., Wilson, R.S., Penn, R.D., (1987) Cortical biopsy results in Alzheimer's disease: correlation with cognitive deficits. Neurology, 37, 1201–1204.CrossRefGoogle ScholarPubMed

McKhann, G., Drachman, D., Folstein, M., (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS–ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed

Merskey, H., Blume, W.T., Colhoun, E.H., (1985) Correlative studies in Alzheimer's disease. Progress in Neuropsychopharmacology and Biological Psychiatry, 9, 509–514.CrossRefGoogle ScholarPubMed

Meyer, J.S., McClintie, K.L., Rogers, R.L., (1988) Aetiological considerations and risk factors for multi–infarct dementia. Journal of Neurology, Neurosurgery and Psychiatry, 51, 1489–1497.CrossRefGoogle ScholarPubMed

Miller, F.B., Hicks, S.P., D'Amato, C.J., (1984) A descriptive study of neuritic plaques and neurofibrillary tangles in an autopsy population. American Journal of Epidemiology, 3, 331–341.CrossRefGoogle Scholar

Mirra, S.S., Heyman, A., McKeel, D., (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II Standardisation of the neuropathic assessment of Alzheimer's disease. Neurology, 41, 479–486.CrossRefGoogle Scholar

Molsa, P.K., Paljarvi, L., Rinne, J.O., (1985) Validity of clinical diagnosis in dementia: a prospective clinicopathological study. Journal of Neurology, Neurosurgery and Psychiatry, 48, 1085–1090.CrossRefGoogle ScholarPubMed

Molsa, P.K., Sako, E., Paljarvi, L., (1987) Alzheimer's disease: neuropathological correlates of cognitive and motor disorders. Acta Neurological Scandinavica, 75, 376–384.CrossRefGoogle ScholarPubMed

Morris, J.C., Mohs, R.C., Rogers, H., (1988a) Consortium to establish a registry for Alzheimer's disease (CERAD). Clinical and neuropsychological assessment for Alzheimer's disease. Psychopharmacology Bulletin, 24, 641–652.Google ScholarPubMed

Morris, J.C., McKeel, D.W., Fulling, K., (1988b) Validation of clinical diagnostic criteria for Alzheimer's disease. Annals of Neurology, 24, 17–22.CrossRefGoogle ScholarPubMed

Morris, J.C., McKeel, D.W., Storandt, M., (1991) Very mild Alzheimer's disease: informant–based clinical, psychometric and pathologic distinction from normal aging. Neurology, 41, 469–478.CrossRefGoogle ScholarPubMed

Mortimer, J. (1992) Risk factors for dementia. Dementia and Normal Ageing (eds Huppert, F., Brayne, C. & O'Connor, D.). Cambridge: Cambridge University Press.Google Scholar

Neary, D., Snowden, J.S., Mann, D.M., (1986) Alzheimer's disease: a correlative study. Journal of Neurology, Neurosurgery and Psychiatry, 49, 229–237.CrossRefGoogle ScholarPubMed

Newton, R.D. (1948) The identity of Alzheimer's disease and senile dementia and their relationship to senility. Journal of Mental Science, 94, 225–249.CrossRefGoogle ScholarPubMed

Osuntokun, B.O., Ogunniyi, L. I. G, Lekwaumwa, T.A., (1991) Epidemiology of dementia in Nigerian Africans. Advances in Neurology (ed. Chopra, J. S.). Amsterdam: Elsevier.Google Scholar

Perl, D.P. & Pendlebury, W.W. (1984) Aluminium accumulation in neurofibrillary tangle (NFT) bearing intraneuronal X–ray spectrometry studies of unstained tissue sections. Journal of Neuropathology and Experimental Neurology, 43, 349.CrossRefGoogle Scholar

Perry, E.K., Tomlinson, B.E., Blessed, G., (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. British Medical Journal, ii, 1457–1459.CrossRefGoogle Scholar

Perry, E.K., Curtis, M., Dick, D.J., (1985) Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 48, 413–421.CrossRefGoogle ScholarPubMed

Pollitt, P. (1992) Carers and dementia. Dementia and Normal Ageing (eds Huppert, F., Brayne, C. & O'Connor, D.). Cambridge: Cambridge University Press.Google Scholar

Risse, S.C., Raskind, M.A., Nochlin, D., (1989) Neuropathological findings in patients with clinical diagnoses of probable Alzheimer's disease. American Journal of Psychiatry, 147, 168–172.Google Scholar

Rose, G. (1989) The mental health of populations. The Scope of Epidemiological Psychiatry (eds Williams, P., Wilkinson, G. & Rawnsley, K.). London and New York: Routledge.Google Scholar

Roth, M., Tomlinson, B.E. & Blessed, G. (1966) Correlation between scores for dementia and counts of “senile plaques” in cerebral grey matter of elderly subjects. Nature, 209, 109–110.CrossRefGoogle ScholarPubMed

Roth, M., Huppert, F., Tym, E., (1988) CAMDEX. The Cambridge Examination for Mental Disorders of the Elderly. Cambridge: Cambridge University Press.Google Scholar

Sulkava, R., Haltia, M., Paetau, A., (1983) Accuracy of clinical diagnosis in primary degenerative dementia: a correlation with neuropathological findings. Journal of Neurology, Neurosurgery and Psychiatry, 46, 9–13.CrossRefGoogle ScholarPubMed

Sumpter, P.Q., Mann, D.M., Davies, C.A., (1986) A quantitative study of the ultrastructure of pyramidal neurons of the cerebral cortex in Alzheimer's disease in relationship to the degree of dementia. Neuropathology and Applied Neurobiology, 12, 321–329.CrossRefGoogle Scholar

Svanborg, A. (1988) The health of the elderly population: results from longitudinal studies with age–cohort comparisons. Research and the Ageing Population. Chichester: Wiley. 134, 3–16.)Google Scholar

Tierney, M.C., Fisher, R.H., Lewis, A.J., (1988) The NINCDS–ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinico-pathological study of 57 cases. Neurology, 38, 359–364.CrossRefGoogle Scholar

Todorov, A.B., Go, R.C., Constantinidis, J., (1975) Specificity of the clinical diagnosis of dementia. Journal of the Neurological Sciences, 26, 81–98.CrossRefGoogle ScholarPubMed

Tomlinson, B.E., Blessed, G. & Roth, M. (1968) Observations on the brains of demented old people. Journal of Neurological Sciences, 7, 331–356.CrossRefGoogle ScholarPubMed

van Duijn, C.M., Hendriks, L., Cruts, M., (1991) Amyloid precursor protein gene mutation in early onset Alzheimer's disease. Lancet, 337, 978.CrossRefGoogle ScholarPubMed

Wade, J.P.H., Mirsen, T.R., Hachinski, V.C., (1987) The clinical diagnosis of Alzheimer's disease. Archives of Neurology, 44, 24–29.CrossRefGoogle ScholarPubMed

Whalley, L.J. (1987) Current Approaches. Alzheimer's Disease (eds Malkin, J. C. & Rossor, M. N.). Duphar Laboratories.Google Scholar

Wilcock, G.K. & Esiri, M.M. (1982) Plaques, tangles and dementia. A quantitative study. Journal of Neurological Sciences, 56, 343–356.CrossRefGoogle ScholarPubMed

Wilcock, G.K., Hope, R.A., Brooks, D.N., (1989) Recommended minimum data to be collected in research studies in Alzheimer's disease. The MRC (UK) Alzheimer's Disease Workshop Steering Committee. Journal of Neurology, Neurosurgery and Psychiatry, 52, 693–700.CrossRefGoogle ScholarPubMed

Wisniewski, H.M., Rabe, A., Silverman, W., (1988) Neuropathological diagnosis of Alzheimer's disease: a survey of current practices. Alzheimer Disease and Associated Disorders, 2, 396–414.CrossRefGoogle Scholar

World Health Organization (1992) The ICD–10 Classification of Mental and Behavioural Disorders. Geneva: WHO.Google Scholar

Zubenko, G.S. (1990) Progression of illness in the differential diagnosis of primary dementia. American Journal of Psychiatry, 147, 435–438.Google ScholarPubMed