Neurobiology of Periventricular Leukomalacia in the Premature Infant (original) (raw)

• Guyer B, Hoyert DL, Martin JA, Ventura SJ, MacDorman MF, Strobino DM 1999 Annual summary of vital statistics—1998. Pediatrics 104: 1229–1246
  PubMed CAS Google Scholar
• Wood NS, Markow N, Costeloe K, Gibson AT, Wilkinson AR 2000 Neurologic and developmental disability after extremely preterm birth. N Engl J Med 343: 378–384
  PubMed CAS Google Scholar
• Hack M, Wilson-Costello D, Friedman H, Taylor GH, Schluchter M, Fanaroff AA 2000 Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g. Arch Pediatr Adolesc Med 154: 725–731
  PubMed CAS Google Scholar
• Hack M, Taylor G, Klein N, Mercuri-Minich N 2000 Functional limitations and special health care needs of 10- to 14-year old children weighing less than 750 grams at birth. Pediatrics 106: 554–560
  PubMed CAS Google Scholar
• Volpe JJ 2001 Neurology of the Newborn. WB Saunders: Philadelphia, 217–497.
  Google Scholar
• Inder T, Huppi PS, Zientara GP, Maier SE, Jolesz FA, di Salvo D, Robertson R, Barnes PD, Volpe JJ 1999 Early detection of periventricular leukomalacia by diffusion-weighted magnetic resonance imaging techniques. J Pediatr 134: 631–634
  PubMed CAS Google Scholar
• De Reuck JL 1984 Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants. Acta Neurol Scand 70: 391–395
  PubMed CAS Google Scholar
• Takashima S, Tanaka K 1978 Development of cerebrovascular architecture and its relationship to periventricular leukomalacia. Arch Neurol 35: 11–16
  PubMed CAS Google Scholar
• Takashima S 1982 Pathology on neonatal hypoxic brain damage and intracranial hemorrhage: factors important in their pathogenesis. In: Fukuyama Y, Arima M, Maekawa K, Yamaguchi K, eds. International Congress Series No. 579, Child Neurology. Excerpta Medica: Amsterdam, 141–153.
  Google Scholar
• Rorke LB 1992 Anatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury. Brain Pathol 2: 211–221
  PubMed CAS Google Scholar
• Larroche JC 1977 Developmental Pathology of the Neonate. Excerpta Medica: New York, 399–408.
  Google Scholar
• Altman DI, Powers WJ, Perlman JM, Herscovitch P, Volpe SL, Volpe JJ 1988 Cerebral blood flow requirement for brain viability in newborn infants is lower than in adults. Ann Neurol 24: 218–226
  PubMed CAS Google Scholar
• Greisen G 1986 Cerebral blood flow in preterm infants during the first week of life. Acta Paediatr Scand 75: 43–51
  PubMed CAS Google Scholar
• Greisen G, Trojaborg W 1987 Cerebral blood flow, Paco2 changes, and visual evoked potentials in mechanically ventilated, preterm infants. Acta Paediatr Scand 76: 394–400
  PubMed CAS Google Scholar
• Pryds O, Greisen G, Friis-Hansen B 1988 Compensatory increase of CBF in preterm infants during hypoglycaemia. Acta Paediatr Scand 77: 632–637
  PubMed CAS Google Scholar
• Pryds O, Greisen G 1989 Effect of Paco2 and haemoglobin concentration on day to day variation of CBF in preterm neonates. Acta Paediatr Scand Suppl 360: 33–36
  PubMed CAS Google Scholar
• Greisen G, Pryds O 1989 Low CBF, discontinuous EEG activity, and periventricular brain injury in ill, preterm neonates. Brain Dev 11: 164–168
  PubMed CAS Google Scholar
• Pryds O, Greisen G, Lou H, Friis-Hansen B 1990 Vasoparalysis associated with brain damage in asphyxiated term infants. J Pediatr 117: 119–125
  PubMed CAS Google Scholar
• Pryds O, Greisen G 1990 Preservation of single-flash visual evoked potentials at very low cerebral oxygen delivery in preterm infants. Pediatr Neurol 6: 151–158
  PubMed CAS Google Scholar
• Borch K, Greisen G 1998 Blood flow distribution in the normal human preterm brain. Pediatr Res 41: 28–33
  Google Scholar
• Powers WJ, Grubb RL, Darriet D, Raichle ME 1985 Cerebral blood flow and cerebral metabolic rate of oxygen requirements for cerebral function and viability in humans. J Cereb Blood Flow Metab 5: 600–608
  PubMed CAS Google Scholar
• Lou HC, Lassen NA, Tweed WA, Johnson G, Jones M, Palahniuk RJ 1979 Pressure passive cerebral blood flow and breakdown of the blood-brain barrier in experimental fetal asphyxia. Acta Paediatr Scand 68: 57–63
  PubMed CAS Google Scholar
• Pryds O, Greisen G, Lou H, Friis-Hansen B 1989 Heterogeneity of cerebral vasoreactivity in preterm infants supported by mechanical ventilation. J Pediatr 115: 638–645
  PubMed CAS Google Scholar
• Pryds O, Edwards AD 1996 Cerebral blood flow in the newborn infant. Arch Dis Child 74: F63–F69
  CAS Google Scholar
• Muller AM, Morales C, Briner J, Baenziger O, Duc G, Bucher HU 1997 Loss of CO2 reactivity of cerebral blood flow is associated with severe brain damage in mechanically ventilated very low birth weight infants. Eur J Paediatr Neurol 5: 157–163
  Google Scholar
• Pryds O 1991 Control of cerebral circulation in the high-risk neonate. Ann Neurol 30: 321–329
  PubMed CAS Google Scholar
• Younkin DP, Reivich M, Jaggi JL, Obrist WD, Delivoria-Papadopoulos M 1987 The effect of hematocrit and systolic blood pressure on cerebral blood flow in newborn infants. J Cereb Blood Flow Metab 7: 295–299
  PubMed CAS Google Scholar
• Boylan GB, Young K, Panerai RB, Rennie JM, Evans DH 2000 Dynamic cerebral autoregulation in sick newborn infants. Pediatr Res 48: 12–17
  PubMed CAS Google Scholar
• Papile LA, Rudolph AM, Heymann MA 1985 Autoregulation of cerebral blood flow in the preterm fetal lamb. Pediatr Res 19: 159–161
  PubMed CAS Google Scholar
• Szymonowicz W, Walker AM, Yu VY, Stewart ML, Cannata J, Cussen L 1990 Regional cerebral blood flow after hemorrhagic hypotension in the preterm, near-term, and newborn lamb. Pediatr Res 28: 361–366
  PubMed CAS Google Scholar
• Tsuji M, du Plessis A, Taylor G, Crocker R, Volpe JJ 1998 Near infrared spectroscopy detects cerebral ischemia during hypotension in piglets. Pediatr Res 44: 591–595
  PubMed CAS Google Scholar
• Soul JS, Taylor GA, Wypij D, du Plessis AJ, Volpe JJ 2000 Noninvasive detection of changes in cerebral blood flow by near-infrared spectroscopy in a piglet model of hydrocephalus. Pediatr Res 48: 445–449
  PubMed CAS Google Scholar
• Tsuji M, Saul JP, du Plessis A, et al 2000 Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatrics 106: 625–632
  PubMed CAS Google Scholar
• Yue X, Mehmet H, Penrice J, Cooper C, Cady E, Wyatt JS, Reynolds EO, Edwards AD, Squier MV 1997 Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia. Neuropathol Appl Neurobiol 23: 16–25
  PubMed CAS Google Scholar
• Rees S, Stringer M, Just Y, Hooper SB, Harding R 1997 The vulnerability of the fetal sheep brain to hypoxemia at mid-gestation. Brain Res Dev Brain Res 103: 103–118
  PubMed CAS Google Scholar
• Mallard EC, Rees S, Stringer M, Cock MI, Harding R 1998 Effects of chronic placental insufficiency on brain development in fetal sheep. Pediatr Res 43: 262–270
  PubMed CAS Google Scholar
• Reddy K, Mallard C, Guan J, Marks K, Bennet L, Gunning M, Gunn A, Gluckman P, Williams C 1998 Maturational change in the cortical response to hypoperfusion injury in the fetal sheep. Pediatr Res 43: 674–682
  PubMed CAS Google Scholar
• Ikeda T, Murata Y, Quilligan EJ, Choi BH, Parer JT, Doi S, Park SD 1998 Physiologic and histologic changes in near- term fetal lambs exposed to asphyxia by partial umbilical cord occlusion. Am J Obstet Gynecol 178: 24–32
  PubMed CAS Google Scholar
• Jelinski SE, Yager JY, Juurlink BHJ 1999 Preferential injury of oligodendroblasts by a short hypoxic-ischemic insult. Brain Res 815: 150–153
  PubMed CAS Google Scholar
• Uehara H, Yoshioka H, Kawase S, Nagai H, Ohmae T, Hasegawa K, Sawada T 1999 A new model of white matter injury in neonatal rats with bilateral carotid artery occlusion. Brain Res 837: 213–220
  PubMed CAS Google Scholar
• Follett PL, Rosenberg PA, Volpe JJ, Jensen FE 2000 NBQX attenuates excitotoxic injury in developing white matter. J Neurosci 20: 9235–9241
  PubMed CAS PubMed Central Google Scholar
• Matsuda T, Okuyama K, Cho K, Hoshi N, Matsumoto Y, Kobayashi Y, Fujimoto S 1999 Induction of antenatal periventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep. Am J Obstet Gynecol 181: 725–730
  PubMed CAS Google Scholar
• Duncan JR, Cock ML, Harding R, Rees SM 2000 Relation between damage to the placenta and the fetal brain after late-gestation placental embolization and fetal growth restriction in sheep. Am J Obstet Gynecol 183: 1013–1022
  PubMed CAS Google Scholar
• Back SA, Luo NL, Borenstein NS, Levine JM, Volpe JJ, Kinney HC 2001 Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci 21: 1302–1312
  PubMed CAS PubMed Central Google Scholar
• Back SA, Gan X, Li Y, Rosenberg PR, Volpe JJ 1998 Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion. J Neurosci 18: 6241–6253
  PubMed CAS PubMed Central Google Scholar
• Halliwell B, Gutteridge JC 1990 Role of free radicals and catalytic metal ions in human disease: an overview. In: Packer AN, ed. Methods in Enzymology, Vol 186. Academic Press: San Diego, 1–85.
  Google Scholar
• Chan PH 1992 Oxygen radicals in focal cerebral ischemia. Brain Pathol 4: 59–65
  Google Scholar
• Rangan U, Bulkley GA 1993 Prospects for treatment of free radical mediated injury. Br Med Bull 49: 700–718
  PubMed CAS Google Scholar
• Fellman V, Raivio KO 1997 Reperfusion injury as the mechanism of brain damage after perinatal asphyxia. Pediatr Res 41: 599–606
  PubMed CAS Google Scholar
• Armstead WM, Mirro R, Busija DW, Leffler CW 1988 Postischemic generation of superoxide anion by newborn pig brain. Am J Physiol 225: H401–H403
  Google Scholar
• Palmer C, Smith MB, Williams GD 1991 Allopurinol preserves cerebral energy metabolism during perinatal hypoxic-ischemic injury and reduces brain damage in a dose dependent manner. J Cereb Blood Flow Metab 11: S114–S149
  Google Scholar
• Palmer C, Towfighi J, Roberts RL, Heitjan DF 1993 Allopurinol administered after inducing hypoxia-ischemia reduces brain injury in 7-day-old rats. Pediatr Res 33: 405–411
  PubMed CAS Google Scholar
• Pourcyrous M, Leffler CW, Bada HS, Korones SB, Busija DW 1993 Brain superoxide anion generation in asphyxiated piglets and the effect of indomethacin at therapeutic dose. Pediatr Res 34: 366–369
  PubMed CAS Google Scholar
• Hasegawa K, Yoshioka H, Sawada T, Nishikawa H 1993 Direct measurement for free radicals in the neonatal mouse brain subjected to hypoxia: an electron spin resonance spectroscopic study. Brain Res 607: 161–166
  PubMed CAS Google Scholar
• Kjellmer I, Andiné P, Hagberg H, Thiringer K 1989 Extracellular increase of hypoxanthine and xanthine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia. Brain Res 478: 241–247
  PubMed CAS Google Scholar
• Palmer C, Vannucci RC, Towfighi J 1990 Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr Res 27: 332–336
  PubMed CAS Google Scholar
• Rosenberg AA, Murdaugh E, White CW 1989 The role of oxygen free radicals in postasphyxia cerebral hypoperfusion in newborn lambs. Pediatr Res 26: 215–219
  PubMed CAS Google Scholar
• Thordstein M, Bagenholm R, Thiringer K, Kjellmer I 1993 Scavengers of free oxygen radicals in combination with magnesium ameliorate perinatal hypoxic-ischemic brain damage in the rat. Pediatric Res 34: 23–26
  CAS Google Scholar
• Bagenholm R, Nilsson A, Gotborg CW, Kjellmer I 1998 Free radicals are formed in the brain of fetal sheep during reperfusion after cerebral ischemia. Pediatr Res 43: 271–275
  PubMed CAS Google Scholar
• Bagenholm R, Nilsson UA, Kjellmer I 1997 Formation of free radicals in hypoxic ischemic brain damage in the neonatal rat, assessed by an endogenous spin trap and lipid peroxidation. Brain Res 773: 132–138
  PubMed CAS Google Scholar
• Palmer C, Menzies SL, Roberts RL, Pavlick G, Connor JR 1999 Changes in iron histochemistry after hypoxic-ischemic brain injury in the neonatal rat. J Neurosci Res 56: 60–71
  PubMed CAS Google Scholar
• Taylor DL, Edwards AD, Mehmet H 1999 Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol 9: 93–117
  PubMed CAS Google Scholar
• Wakatsuki A, Izumiya C, Okatani Y, Sagara Y 1999 Oxidative damage in fetal rat brain induced by ischemia and subsequent reperfusion: relation to arachidonic acid peroxidation. Biol Neonate 76: 84–91
  PubMed CAS Google Scholar
• Tan S, Zhou F, Nielsen VG, Wang ZW, Gladson CL, Parks DA 1999 Increased injury following intermittent fetal hypoxia-reoxygenation is associated with increased free radical production in fetal rabbit brain. J Neuropathol Exp Neurol 58: 972–981
  PubMed CAS Google Scholar
• Sarco DP, Becker J, Palmer C, Sheldon RA, Ferriero DM 2000 The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain. Neurosci Lett 282: 113–116
  PubMed CAS Google Scholar
• Fullerton HJ, Ditelberg JS, Chen SF, et al 1998 Copper/zinc superoxide dismutase transgenic brain accumulates hydrogen peroxide after perinatal hypoxia ischemia. Ann Neurol 44: 357–364
  PubMed CAS Google Scholar
• Chan PH 2001 Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cerebral Blood Flow Metab 21: 2–14
  CAS Google Scholar
• Rosenberg PA, Li Y, Back SA, Volpe JJ 1999 Intracellular redox state determines whether nitric oxide is toxic or protective to rat oligodendrocytes in culture. J Neurochem 73: 476–484
  PubMed CAS Google Scholar
• Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ 1993 Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms and prevention. J Neurosci 13: 1441–1453
  PubMed CAS PubMed Central Google Scholar
• Yonezawa M, Back SA, Gan X, Rosenberg PA, Volpe JJ 1996 Cystine deprivation induces oligodendroglial death: rescue by free radical scavengers and by a diffusible glial factor. J Neurochem 67: 566–573
  PubMed CAS Google Scholar
• Bonfoco E, Krainc D, Ankacrona M, Nicotera P, Lipton SA 1995 Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with _N_-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci USA 92: 7162–7166
  PubMed CAS PubMed Central Google Scholar
• Choi DW 1996 Ischemia-induced neuronal apoptosis. Curr Opin Neurobiol 6: 667–672
  PubMed CAS Google Scholar
• Gilles FH, Leviton A, Dooling EC 1983 The Developing Human Brain: Growth and Epidemiologic Neuropathology. John Wright, Inc: Boston, 244–315.
  Google Scholar
• Rorke LB 1982 Pathology of Perinatal Brain Injury. Raven Press: New York, 45–67.
  Google Scholar
• Connor JR, Fine RE 1987 Development of transferrin-positive oligodendrocytes in the rat central nervous system. J Neurosci Res 17: 51–59
  PubMed CAS Google Scholar
• Connor JR, Menzies SL 1990 Altered distribution of iron in the central nervous system of myelin deficient rats. Neuroscience 34: 265–271
  PubMed CAS Google Scholar
• Connor JR, Menzies SL 1996 Relationship of iron to oligodendrocytes and myelination. Glia 17: 83–93
  PubMed CAS Google Scholar
• Thorburne SK, Juurlink BHJ 1996 Low glutathione and high iron govern the susceptibility of oligodendroglial precursors to oxidative stress. J Neurochem 67: 1014–1022
  PubMed CAS Google Scholar
• Juurlink BHJ 1997 Response of glial cells to ischemia: roles of reactive oxygen species and glutathione. Neurosci Biobehav Rev 21: 151–166
  PubMed CAS Google Scholar
• Juurlink BHJ, Thorburne SK, Hertz L 1998 Peroxide-scavenging deficit underlies oligodendrocyte susceptibility to oxidative stress. Glia 22: 371–378
  PubMed CAS Google Scholar
• Laszkiewicz I, Mouzannar R, Wiggins RC, Konat GW 1999 Delayed oligodendrocyte degeneration induced by brief exposure to hydrogen peroxide. J Neurosci Res 55: 303–310
  PubMed CAS Google Scholar
• Ditelberg JS, Sheldon RA, Epstein CJ, Ferriero DM 1996 Brain injury after perinatal hypoxia-ischemia is exacerbated in copper/zinc superoxide dismutase transgenic mice. Pediatr Res 39: 204–208
  PubMed CAS Google Scholar
• Groenendaal F, Shadid M, McGowan JE, Mishra OP, van Bel F 2000 Effects of deferoxamine, a chelator of free iron, on Na+,K+-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs. Pediatr Res 48: 560–654
  PubMed CAS Google Scholar
• Houdou S, Kuruta H, Hasegawa M 1991 Developmental immunohistochemistry of catalase in the human brain. Brain Res 556: 267–270
  PubMed CAS Google Scholar
• Ozawa H, Nishida A, Mito T, Takashima S 1994 Development of ferritin-positive cells in cerebrum of human brain. Pediatr Neurol 10: 44–48
  PubMed CAS Google Scholar
• Iida K, Takashima S, Ueda K 1995 Immunohistochemical study of myelination and oligodendrocyte in infants with periventricular leukomalacia. Pediatr Neurol 13: 296–304
  PubMed CAS Google Scholar
• Varsila E, Pitkanen O, Hallman M, Andersson S 1994 Immaturity-dependent free radical activity in premature infants. Pediatr Res 36: 55–59
  PubMed CAS Google Scholar
• Ogihara T, Okamoto R, Kim HS, Nagai A, Morinobu T, Moji H, Kamegai H, Hirano K, Ogihara H, Tamai H, Mino M 1996 New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease. Pediatr Res 39: 117–119
  PubMed CAS Google Scholar
• Inder TE, Darlow BA, Winterbourn SKB, Graham CC, Sanderson P, Taylor KJ 1996 The correlation of elevated levels of an index of lipid peroxidation (MDA-TBA) with adverse outcome in the very low birthweight infant. Acta Paediatr 85: 1116–1122
  PubMed CAS Google Scholar
• Lubec G, Widness JA, Hayde M, Menzel D, Pollak A 1997 Hydroxyl radical generation in oxygen-treated infants. Pediatrics 100: 700–704
  PubMed CAS Google Scholar
• Lackmann GM, Hesse L, Tollner U 1996 Reduced iron-associated antioxidants in premature newborns suffering intracerebral hemorrhage. Free Radic Biol Med 20: 407–409
  PubMed CAS Google Scholar
• Saugstad OD 1997 Bronchopulmonary dysplasia and oxidative stress: are we closer to an understanding of the pathogenesis of BPD?. Acta Paediatr 86: 1277–1282
  PubMed CAS Google Scholar
• Silvers KM, Gibson AT, Russell JM, Powers HJ 1998 Antioxidant activity, packed cell transfusions, and outcome in premature infants. Arch Dis Child 78: F214–F219
  CAS Google Scholar
• Luukkainen R, Aejmelaeus R, Alho H, MetsaKetela T, Ikonen SR, Salo MK 1999 Plasma chain-breaking antioxidants in preterm infants with good and poor short-term outcome. Free Radic Res 30: 189–197
  PubMed CAS Google Scholar
• Rogers S, Witz G, Anwar M, Hiatt M, Hegyi T 2000 Antioxidant capacity and oxygen radical diseases in the preterm newborn. Arch Pediatr Adolesc Med 154: 544–548
  PubMed CAS Google Scholar
• Buonocore G, Perrone S, Longini M, Terzuoli L, Bracci R 2000 Total hydroperoxide and advanced oxidation protein products in preterm hypoxic babies. Pediatr Res 47: 221–224
  PubMed CAS Google Scholar
• Inder TE, Mocatta T, Darlow BA, Winterbourn CC 2000 Elevated free radical products in the cerebrospinal fluid of premature infants with white matter injury. Ann Neurol Abstr 48: 37( abstr)
  Google Scholar
• Armstrong DL, Sauls CD, Goddard-Finegold J 1987 Neuropathologic findings in short-term survivors of intraventricular hemorrhage. Am J Dis Child 141: 617–621
  PubMed CAS Google Scholar
• Takashima S, Mito T, Houdou S, Ando Y 1989 Relationship between periventricular hemorrhage, leukomalacia and brainstem lesions in prematurely born infants. Brain Dev 11: 121–124
  PubMed CAS Google Scholar
• Leviton A, Gilles F 1996 Ventriculomegaly, delayed myelination, white matter hypoplasia, and “periventricular” leukomalacia. How are they related?. Pediatr Neurol 15: 127–136
  PubMed CAS Google Scholar
• Kuban K, Sanocka U, Leviton A, Allred EN, Pagano M, Dammann O, Share J, Rosenfeld D, Abiri M, DiSalvo D, Doubilet P, Kairam R, Kazam E, Kirpekar M, Schonfeld S 1999 White matter disorders of prematurity: association with intraventricular hemorrhage and ventriculomegaly. J Pediatr 134: 539–546
  PubMed CAS Google Scholar
• Savman K, Nilsson UA, Blennow M, Kjellmer I, Whitelaw A 2001 Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilation. Pediatr Res 49: 208–212
  PubMed CAS Google Scholar
• Banker BQ, Larroche JC 1962 Periventricular leukomalacia of infancy. Arch Neurol 7: 386–410
  PubMed CAS Google Scholar
• Meng SZ, Arai Y, Deguchi K, Takashima S 1997 Early detection of axonal and neuronal lesions in prenatal-onset periventricular leukomalacia. Brain Dev 19: 480–484
  PubMed CAS Google Scholar
• Deguchi K, Oguchi K, Matsuura N, Armstrong DD, Takashima S 1999 Periventricular leukomalacia: relation to gestational age and axonal injury. Pediatr Neurol 20: 370–374
  PubMed CAS Google Scholar
• Ohyu J, Marumo G, Ozawa H, Takashima S, Nakajima K, Kohsaka S, Hamai Y, Machida Y, Kobayashi K, Ryo E, Baba K, Kozuma S, Okai T, Taketani Y 1999 Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion. Brain Dev 21: 248–252
  PubMed CAS Google Scholar
• Battistin L, Grynbaum A, Lajtha A 1971 The uptake of various amino acids by the mouse brain in vivo. Brain Res 29: 85–99
  PubMed CAS Google Scholar
• Fonnum FJ 1984 Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42: 1–11
  PubMed CAS Google Scholar
• Beneveniste H 1991 The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovasc Metab Rev 3: 213–245
  Google Scholar
• Fern R, Moller T 2000 Rapid ischemic cell death in immature oligodendrocytes: a fatal glutamate release feedback loop. J Neurosci 20: 34–42
  PubMed CAS PubMed Central Google Scholar
• Nicholls D, Attwell D 1991 The release and uptake of excitatory amino acids. Trends Pharmacol Sci 13: 68–74
  Google Scholar
• Yoshioka A, Bacskai B, Pleasure D 1996 Pathophysiology of oligodendroglial excitotoxicity. J Neurosci Res 46: 427–438
  PubMed CAS Google Scholar
• McDonald JW, Althomsons SP, Hyrc KL, Choi DW, Goldberg MP 1998 Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity. Nat Med 4: 291–297
  PubMed CAS Google Scholar
• Matute C, SanchezGomez MV, MartinezMillan L, Miledi R 1997 Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc Natl Acad Sci USA 94: 8830–8835
  PubMed CAS PubMed Central Google Scholar
• Gan XD, Back SA, Rosenberg PA, Volpe JJ 1997 Stage-specific vulnerability of rat oligodendrocytes in culture to non-NMDA receptor mediated toxicity. Soc Neurosci 2: 17420 Abstr
  Google Scholar
• Matute C 1998 Characteristics of acute and chronic kainate excitotoxic damage to the optic nerve. Proc Natl Acad Sci USA 95: 10229–10234
  PubMed CAS PubMed Central Google Scholar
• Sanchez-Gomez MV, Matute C 1999 AMPA and kainate receptors each mediate excitotoxicity in oligodendroglial cultures. Neurobiol Dis 6: 475–485
  PubMed CAS Google Scholar
• Pitt D, Werner P, Raine CS 2000 Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 6: 67–70
  PubMed CAS Google Scholar
• Yoshioka A, Yamaya Y, Saiki S, Kanemoto M, Hirose G, Beesley J, Pleasure D 2000 Non-_N_-methyl-d-aspartate glutamate receptors mediate oxygen–glucose deprivation-induced oligodendroglial injury. Brain Res 854: 207–215
  PubMed CAS Google Scholar
• Follett PL, Koh S, Fu JM, Volpe JJ, Jensen FE 2000 Protective effects of topiramate in a rodent model of periventricular leukomalacia. Ann Neurol 48: 34A
  Google Scholar
• Gilles FH, Leviton A, Kerr CS 1976 Susceptibility of the neonatal feline telencephalic white matter to a lipopolysaccharide. J Neurol Sci 27: 183–191
  PubMed CAS Google Scholar
• Gilles FH, Averill DR, Kerr CS 1977 Neonatal endotoxin encephalopathy. Ann Neurol 2: 49–56
  PubMed CAS Google Scholar
• Leviton A, Gilles FH 1984 Acquired perinatal leukoencephalopathy. Ann Neurol 16: 1–10
  PubMed CAS Google Scholar
• Yoon BH, Kim CJ, Romero R, Jun JK, Park KH, Choi ST, Chi JG 1997 Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits. Am J Obstet Gynecol 177: 797–802
  PubMed CAS Google Scholar
• Debillon T, Gras-Leguen C, Verielle V, Winer N, Caillon J, Roze JC, Gressens P 2000 Intrauterine infection induces programmed cell death in rabbit periventricular white matter. Pediatr Res 47: 736–742
  PubMed CAS Google Scholar
• Perlman JM, Risser R, Broyles RS 1996 Bilateral cystic periventricular leukomalacia in the premature infant: associated risk factors. Pediatrics 97: 822–827
  PubMed CAS Google Scholar
• Zupan V, Gonzalez P, Lacaze-Masmonteil T, Boithias C, d'Allest AM, Dehan M, Gabilan JC 1996 Periventricular leukomalacia: risk factors revisited. Dev Med Child Neurol 38: 1061–1067
  PubMed CAS Google Scholar
• Grether JK, Nelson KB, Emery ES, Cummins SK 1996 Prenatal and perinatal factors and cerebral palsy in very low birth weight infants. J Pediatr 128: 407–414
  PubMed CAS Google Scholar
• O'Shea TM, Klinepeter KL, Meis PJ, Dillard RG 1998 Intrauterine infection and the risk of cerebral palsy in very low-birthweight infants. Pediatr Perinatal Epidemiol 12: 72–83
  CAS Google Scholar
• Baud O, Ville Y, Zupan V, Boithias C, Lacaze-Masmonteil T, Gabilan JC, Frydman R, Dehan M 1998 Are neonatal brain lesions due to intrauterine infection related to mode of delivery?. Br J Obstet Gynaecol 105: 121–124
  PubMed CAS Google Scholar
• Dammann O, Allred EN, Veelken N 1998 Increased risk of spastic diplegia among very low birth weight children after preterm labor or prelabor rupture of membranes. J Pediatr 132: 531–535
  PubMed CAS Google Scholar
• Leviton A, Paneth N, Reuss ML, Susser M, Allred EN, Dammann O, Kuban K, Van Marter LJ, Pagano M, Hegyi T, Hiatt M, Sanocka U, Shahrivar F, Abiri M, Disalvo D, Doubilet P, Kairam R, Kazam E, Kirpekar M, Rosenfeld D, Schonfeld S, Share J, Collins M, Genest D, Shen-Schwarz S 1999 Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Pediatr Res 46: 566–575
  PubMed CAS Google Scholar
• Hansen A, Leviton A 1999 Labor and delivery characteristics and risks of cranial ultrasonographic abnormalities among very-low-birth-weight infants. Am J Obstet Gynecol 181: 997–1006
  PubMed CAS Google Scholar
• Redline RW, Wilson-Costelo D, Borawski E, Fanaroff AA, Hack M 2000 The relationship between placental and other perinatal risk factors for neurologic impairment in very low birth weight children. Pediatr Res 47: 721–726
  PubMed CAS Google Scholar
• Resch B, Vollaard E, Maurer U, Haas J, Rosegger H, Muller W 2000 Risk factors and determinants of neurodevelopmental outcome in cystic periventricular leucomalacia. Eur J Pediatr 159: 663–670
  PubMed CAS Google Scholar
• Wu YW, Colford JM 2000 Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA 284: 1417–1424
  PubMed CAS Google Scholar
• Yoon BH, Romero R, Park JS, Kim CJ, Kim SH, Choi JH, Han TR 2000 Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 182: 675–681
  PubMed CAS Google Scholar
• De Felice C, Toti P, Laurini RN, Stumpo M, Picciolini E, Todros T, Tanganelli P, Buonocore G, Bracci R 2001 Early neonatal brain injury in histologic chorioamnionitis. J Pediatr 138: 101–104
  PubMed CAS Google Scholar
• Yoon BH, Romero R, Yang SH, Jun JK, Kim IO, Choi JH, Syn HC 1996 Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 174: 1433–1440
  PubMed CAS Google Scholar
• Yoon BH, Jun JK, Romero R, Park KH, Gomez R, Choi JH, Kim IO 1997 Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1β, and tumor necrosis factor-α), neontal brian white matter lesions, and cerebral palsy. Am J Obstet Gynecol 177: 19–26
  PubMed CAS Google Scholar
• Grether JK, Nelson KB 1997 Maternal infection and cerebral palsy in infants of normal birth weight. JAMA 287: 207–211
  Google Scholar
• Nelson KB, Dambrosia JM, Grether JK, Phillips TM 1998 Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 44: 665–675
  PubMed CAS Google Scholar
• Grether JK, Nelson KB, Dambrosia JM, Phillips TM 1999 Interferons and cerebral palsy. J Pediatr 134: 324–332
  PubMed CAS Google Scholar
• Deguchi K, Mizuguchi M, Takashima S 1996 Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia. Pediatr Neurol 14: 13–16
  PubMed CAS Google Scholar
• Deguchi K, Oguchi K, Takashima S 1997 Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol 16: 296–300
  PubMed CAS Google Scholar
• Yoon BH, Romero R, Kim CJ, Koo JN, Choe G, Syn HC, Chi JG 1997 High expression of tumor necrosis factor-alpha and interleukin-6 in periventricular leukomalacia. Am J Obstet Gynecol 177: 406–411
  PubMed CAS Google Scholar
• Selmaj K, Raine CS, Farooq M 1991 Cytokine cytotoxicity against oligodendrocytes: apoptosis induced by lymphotoxin. J Immunol 147: 1522–1529
  PubMed CAS Google Scholar
• Louis JC, Magal E, Takayama S, Varon S 1993 CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259: 689–692
  PubMed CAS Google Scholar
• Mayer M, Noble M 1994 _N_-acetyl- l -cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proc Natl Acad Sci USA 91: 7496–7500
  PubMed CAS PubMed Central Google Scholar
• Vartanian T, Li Y, Zhao MJ, Stefansson K 1995 Interferon-γ-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1: 732–743
  PubMed PubMed Central CAS Google Scholar
• Agresti C, D'Urso D, Levi G 1996 Reversible inhibitory effects of interferon-γ- and tumour necrosis factor-α on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur J Neurosci 8: 1106–1116
  PubMed CAS Google Scholar
• Merrill JE, Ignarro LJ, Sherman MP 1993 Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151: 2132–2141
  PubMed CAS Google Scholar
• Andrews T, Zhang P, Bhat NR 1998 TNFα potentiates IFNγ-induced cell death in oligodendrocyte progenitors. J Neurosci Res 54: 574–583
  PubMed CAS Google Scholar
• Burgmaier G, Schonrock LM, Kuhlmann T, Richter-Landsberg C, Bruck W 2000 Association of increased Bcl-2 expression with rescue from tumor necrosis factor-α- induced cell death in the oligodendrocyte cell line OLN-93. J Neurochem 75: 2270–2276
  PubMed CAS PubMed Central Google Scholar
• Popko B, Baerwald KD 1999 Oligodendroglial response to the immune cytokine interferon gamma. Neurochem Res 24: 331–338
  PubMed CAS Google Scholar
• Baerwald KD, Popko B 1998 Developing and mature oligodendrocytes respond differently to the immune cytokine interferon-gamma. J Neurosci Res 52: 230–239
  PubMed CAS Google Scholar
• Dommergues M-A, Patkai J, Renauld J-C, Evrard P, Gressens P 2000 Proinflammatory cytokines and interleukin-9 exacerbate excitotoxic lesions of the newborn murine neopallium. Ann Neurol 47: 54–63
  PubMed CAS Google Scholar
• Tahraoui SL, Marret S, Bodenant C, Leroux P, Dommergues MA, Evrard P, Gressens P 2001 Central role of microglia in neonatal excitotoxic lesions ef the murine periventricular white matter. Brain Pathol 11: 56–71
  PubMed CAS Google Scholar
• Gehrmann J, Banati RB, Wiessnert C, Hossmann KA, Kreutzberg GW 1995 Reactive microglia in cerebral ischaemia: an early mediator of tissue damage?. Neuropathol Appl Neurobiol 21: 277–289
  PubMed CAS Google Scholar
• Park YM, Han M-Y, Blackburn RV, Lee YJ 1998 Overexpression of HSP25 reduces the level of TNFα-induced oxidative DNA damage biomarker, 8-hydroxy-2′-deoxyguanosine, in L929 cells. J Cell Physiol 174: 27–34
  PubMed CAS Google Scholar
• Basu S, Eriksson M 1998 Oxidative injury and survival during endotoxemia. FEBS Lett 438: 159–160
  PubMed CAS Google Scholar
• Trembovler V, BeitYannai E, Younis F, Gallily R, Horowitz M, Shohami E 1999 Antioxidants attenuate acute toxicity of tumor necrosis factor-alpha induced by brain injury in rat. J Interferon Cytokine Res 19: 791–795
  PubMed CAS Google Scholar
• Wilde GJC, Pringle AK, Sundstrom LE, Mann DA, Iannotti F 2000 Attenuation and augmentation of ischaemia-related neuronal death by tumour necrosis factor-alpha in vitro. Eur J Neurosci 12: 3863–3870
  PubMed CAS Google Scholar
• Gaynor E, Bouvier C, Spaet TH 1970 Vascular lesions: possible pathogenetic basis of the generalized Shwartzman reaction. Science 170: 986–988
  PubMed CAS Google Scholar
• McGrath JM, Stewart GJ 1969 The effects of endotoxin on vascular endothelium. J Exp Med 129: 833–848
  PubMed PubMed Central CAS Google Scholar
• Young RS, Yagel SK, Towfighi J 1983 Systemic and neuropathologic effects of E. coli endotoxin in neonatal dogs. Pediatr Res 17: 349–353
  PubMed CAS Google Scholar
• Ando M, Takashima S, Mito T 1988 Endotoxin, cerebral blood flow, amino acids and brain damage in young rabbits. Brain Dev 10: 365–370
  PubMed CAS Google Scholar
• Brian JE, Faraci FM 1998 Tumor necrosis factor-α-induced dilatation of cerebral arterioles. Stroke 29: 509–515
  PubMed CAS Google Scholar
• Grether JK, Hoogstrate J, WalshGreene E, Nelson KB 2000 Magnesium sulfate for tocolysis and risk of spastic cerebral palsy in premature children born to women without preeclampsia. Am J Obstet Gynecol 183: 717–725
  PubMed CAS Google Scholar
• Leviton A, Dammann O, Allred EN, Kuban K, Pagano M, Van Marter L, Paneth N, Reuss ML, Susser M 1999 Antenatal corticosteroids and cranial ultrasonographic abnormalities. Am J Obstet Gynecol 181: 1007–1017
  PubMed CAS Google Scholar
• Canterino JC, Verma U, Visintainer PF, Elimian A, Klein SA, Tejani N 2001 Antenatal steroids and neonatal periventricular leukomalacia. Obstet Gynecol 97: 135–139
  PubMed CAS Google Scholar
• Whitelaw A, Thoresen M 2000 Antenatal steroids and the developing brain. Arch Dis Child Fetal Neonatal Ed 83: F154–F157
  PubMed PubMed Central CAS Google Scholar
• Shinwell ES, Karplus M, Reich D, Weintraub Z, Blazer S, Bader D, Yurman S, Dolfin T, Kogan A, Dollberg S, Arbel E, Goldberg M, Gur I, Naor N, Sirota L, Mogilner S, Zaritsky A, Barak M, Gottfried E 2000 Early postnatal dexamethasone treatment and increased incidence of cerebral palsy. Arch Dis Child Fetal Neonatal Ed 83: F177–F181
  PubMed PubMed Central CAS Google Scholar
• Murphy BP, Inder TE, Huppi PS, Warfield S, Zientara GP, Kikinis R, Jolesz FA, Volpe JJ 2001 Impaired cerebral cortical gray matter growth after treatment with dexamethasone for neonatal chronic lung disease. Pediatrics 107: 217–221
  PubMed CAS Google Scholar
• Thebaud B, Lacaze-Masmonteil T, Watterberg K 2001 Postnatal glucocorticoids in very preterm infants: “the good, the bad, and the ugly”?. Pediatrics 107: 413–415
  PubMed CAS Google Scholar