Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus (original) (raw)

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1Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 862 (P.C., O.L.), F-33077 Bordeaux, France

2Neurocentre Magendie, and Université de Bordeaux (P.C., M.G., O.L.), F-33077 Bordeaux, France

*Address all correspondence and requests for reprints to: Philippe Ciofi, Institut National de la Santé et de la Recherche Médicale Unité 862, Neurocentre Magendie, 146 rue Léo Saignat, F-33077 Bordeaux Cedex, France.

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2Neurocentre Magendie, and Université de Bordeaux (P.C., M.G., O.L.), F-33077 Bordeaux, France

3Centre National de la Recherche Scientifique (M.G.), Unite Mixte de Recherche 5227, F-33077 Bordeaux, France

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1Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 862 (P.C., O.L.), F-33077 Bordeaux, France

2Neurocentre Magendie, and Université de Bordeaux (P.C., M.G., O.L.), F-33077 Bordeaux, France

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4EA2972 (P.L.), Université de Bordeaux, F-33405 Talence, France

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5INSERM Unité 837 (A.L., V.P.), F-59045 Lille, France

6Université de Lille 2 (A.L., V.P.), F-59045 Lille, France

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5INSERM Unité 837 (A.L., V.P.), F-59045 Lille, France

6Université de Lille 2 (A.L., V.P.), F-59045 Lille, France

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7Department of Neurobiology and Physiology (J.E.L.), Northwestern University, Evanston, IL 60208

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Published:

01 December 2009

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Philippe Ciofi, Maurice Garret, Olivier Lapirot, Pierrette Lafon, Anne Loyens, Vincent Prévot, Jon E. Levine, Brain-Endocrine Interactions: A Microvascular Route in the Mediobasal Hypothalamus, Endocrinology, Volume 150, Issue 12, 1 December 2009, Pages 5509–5519, https://doi.org/10.1210/en.2009-0584
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Abstract

Blood-borne hormones acting in the mediobasal hypothalamus, like those controlling food intake, require relatively direct access to target chemosensory neurons of the arcuate nucleus (ARC). An anatomical substrate for this is a permeable microvasculature with fenestrated endothelial cells in the ARC, a system that has awaited comprehensive documentation. Here, the immunofluorescent detection of endothelial fenestral diaphragms in the rat ARC allowed us to quantitate permeable microvessels throughout its rostrocaudal extent. We have determined that permeable microvessels are part of the subependymal plexus irrigating exclusively the ventromedial (vm) ARC from the subadjacent neuroendocrine median eminence. Unexpectedly, permeable microvessels were concentrated proximal to the pituitary stalk. This marked topography strongly supports the functional importance of retrograde blood flow from the pituitary to the vmARC, therefore making a functional relationship between peripheral long-loop, pituitary short-loop, and neuroendocrine ultra-short loop feedback, altogether converging for integration in the vmARC (formerly known as the hypophysiotrophic area), thereby so pivotal as a multicompetent brain endocrinostat.

Copyright © 2009 by The Endocrine Society

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