Intraperitoneal CCK and Fourth-Intraventricular Apo AIV Require Both Peripheral and NTS CCK1R to Reduce Food Intake in Male Rats (original) (raw)

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

*Address all correspondence and requests for reprints to: Chunmin C. Lo,

Departments of Pathology and Laboratory Medicine, 2120 East Galbraith Road, Building A, Cincinnati, OH 45237–0507.

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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1Departments of Pathology and Laboratory Medicine (C.C.L., W.S.D., S.K.H., M.G., A.L., P.T.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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2Departments of Psychiatry and Behavioral Neuroscience (S.C.W.), Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio 45237–0507

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Received:

11 September 2013

Accepted:

12 February 2014

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Chunmin C. Lo, W. Sean Davidson, Stephanie K. Hibbard, Maria Georgievsky, Alexander Lee, Patrick Tso, Stephen C. Woods, Intraperitoneal CCK and Fourth-Intraventricular Apo AIV Require Both Peripheral and NTS CCK1R to Reduce Food Intake in Male Rats, Endocrinology, Volume 155, Issue 5, 1 May 2014, Pages 1700–1707, https://doi.org/10.1210/en.2013-1846
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Apolipoprotein AIV (Apo AIV) and cholecystokinin (CCK) are secreted in response to fat consumption, and both cause satiation via CCK 1 receptor (CCK-1R)-containing vagal afferent nerves to the nucleus of the solitary tract (NTS), where Apo AIV is also synthesized. Fasted male Long-Evans rats received ip CCK-8 or fourth-ventricular (i4vt) Apo AIV alone or in combination. Food intake and c-Fos proteins (a product of the c-Fos immediate-early gene) were assessed. i4vt Apo AIV and/or ip CCK at effective doses reduced food intake and activated c-Fos proteins in the NTS and hypothalamic arcuate nucleus and paraventricular nucleus. Blockade of the CCK-1R by i4vt lorglumide adjacent to the NTS attenuated the satiating and c-Fos-stimulating effects of CCK and Apo AIV, alone or in combination. Maintenance on a high-fat diet (HFD) for 10 weeks resulted in weight gain and attenuation of both the behavioral and c-Fos responses to a greater extent than occurred in low-fat diet-fed and pair-fed HFD animals. These observations suggest that NTS Apo AIV or/and peripheral CCK requires vagal CCK-1R signaling to elicit satiation and that maintenance on a HFD reduces the satiating capacity of these 2 signals.

Copyright © 2014 by the Endocrine Society

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