Myocardial Triglyceride Content and Epicardial Fat Mass in Human Obesity: Relationship to Left Ventricular Function and Serum Free Fatty Acid Levels (original) (raw)

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

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2Departments of Clinical Physiology (J.P.P.), FIN-20521, Turku, Finland

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3Radiology (M.K., R.P.), FIN-20521, Turku, Finland

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

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5PET Centre (E.F., P.I.), 56126 Pisa, Italy

6Institute of Clinical Physiology, CNR National Research Council, and Department of Internal Medicine (E.F.), University of Pisa School of Medicine, 56126 Pisa, Italy

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

4Medicine (P.N., P.I.), University of Turku, FIN-20521, Turku, Finland

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3Radiology (M.K., R.P.), FIN-20521, Turku, Finland

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1Turku PET Centre (M.K., H.-R.L., A.V., J.K., P.N., P.I.) FIN-20521, Turku, Finland

4Medicine (P.N., P.I.), University of Turku, FIN-20521, Turku, Finland

5PET Centre (E.F., P.I.), 56126 Pisa, Italy

*Address all correspondence and requests for reprints to: Patricia Iozzo, M.D., Ph.D., Turku PET Centre, University of Turku, P.O. Box 52, FIN-20521, Turku, Finland.

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Published:

01 November 2006

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Mikko Kankaanpää, Hanna-Riikka Lehto, Jussi P. Pärkkä, Markku Komu, Antti Viljanen, Ele Ferrannini, Juhani Knuuti, Pirjo Nuutila, Riitta Parkkola, Patricia Iozzo, Myocardial Triglyceride Content and Epicardial Fat Mass in Human Obesity: Relationship to Left Ventricular Function and Serum Free Fatty Acid Levels, The Journal of Clinical Endocrinology & Metabolism, Volume 91, Issue 11, 1 November 2006, Pages 4689–4695, https://doi.org/10.1210/jc.2006-0584
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Abstract

Context and Objective: Ectopic fat accumulation within and around the myocardial wall has been implicated in the pathogenesis of heart disease in obesity. We evaluated myocardial and epicardial fat, left ventricular (LV) function, and metabolic risk factors in nine (five lean, four moderately obese) men.

Methods: Myocardial fat percent was quantified in the septum by proton magnetic resonance spectroscopy. Reproducibility was assessed by triplicate systolic and diastolic measurements. LV parameters and epicardial fat were determined by magnetic resonance imaging. Waist-to-hip ratio and liver enzymes (alanine transaminase) were used as surrogate markers of visceral and liver fat contents.

Results: Myocardial fat (2.1 ± 0.5 vs. 0.8 ± 0.1, P = 0.03) and epicardial fat (120 ± 33 vs. 55 ± 12 g, P = 0.08) were higher in obese than lean subjects. Individuals with above-median alanine transaminase values had a 4-fold elevation in myocardial fat. The coefficient of variation of repeated myocardial fat percent determinations was 17 ± 3 and 23 ± 3% in systole and diastole, respectively. Myocardial fat was correlated with free fatty acid (FFA) levels (r = 0.76; P = 0.017), epicardial fat (r = 0.69; P = 0.042), and waist-to-hip ratio (r = 0.70; P = 0.035), and it showed a tendency to associate positively with LV work. Epicardial fat was associated with peripheral vascular resistance (positively) and the cardiac index (negatively). FFA levels were significantly correlated with LV mass (r = 0.72; P = 0.030) and forward work (r = 0.74; P = 0.023).

Conclusions/Interpretation: The accumulation of triglyceride in and around the myocardium of moderately obese individuals is significant, and it is related to FFA exposure, generalized ectopic fat excess, and peripheral vascular resistance. These changes precede LV overload and hypertrophy.

Copyright © 2006 by The Endocrine Society

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