Comparison of Ethinyl-Estradiol Plus Cyproterone Acetate Versus Metformin Effects on Classic Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome (original) (raw)

Journal Article

,

1_Departments of Endocrinology (M.L.-R., F.A.-B., J.I.B.-C., E.M.-B., H.F.E.-M.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

Search for other works by this author on:

,

Francisco Álvarez-Blasco

1_Departments of Endocrinology (M.L.-R., F.A.-B., J.I.B.-C., E.M.-B., H.F.E.-M.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

Search for other works by this author on:

,

José I. Botella-Carretero

1_Departments of Endocrinology (M.L.-R., F.A.-B., J.I.B.-C., E.M.-B., H.F.E.-M.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

Search for other works by this author on:

,

1_Departments of Endocrinology (M.L.-R., F.A.-B., J.I.B.-C., E.M.-B., H.F.E.-M.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

Search for other works by this author on:

,

2_Department of Biochemistry-Research (M.A.L.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

3_Department of Centro de Investigación Biomédica en Red (CIBER) Fisiopatologia Obesidad y Nutrición (CB06/03) (M.A.L.), Instituto de Salud Carlos III, E-28029 Madrid, Spain_

Search for other works by this author on:

Héctor F. Escobar-Morreale

1_Departments of Endocrinology (M.L.-R., F.A.-B., J.I.B.-C., E.M.-B., H.F.E.-M.), Hospital Universitario Ramón y Cajal and Universidad de Alcalá, E-28034 Madrid, Spain_

*Address all correspondence and requests for reprints to: Héctor F. Escobar-Morreale, M.D., Ph.D., Department of Endocrinology, Hospital Universitario Ramón y Cajal and Universidad de Alcalá, Carretera de Colmenar Viejo Km 9,1. 28034 Madrid, Spain.

Search for other works by this author on:

Received:

07 February 2007

• • Article contents
  • Figures & tables
  • Video
  • Audio
  • Supplementary Data
• Cite

Cite

Manuel Luque-Ramírez, Francisco Álvarez-Blasco, José I. Botella-Carretero, Elena Martínez-Bermejo, Miguel A. Lasunción, Héctor F. Escobar-Morreale, Comparison of Ethinyl-Estradiol Plus Cyproterone Acetate Versus Metformin Effects on Classic Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome, The Journal of Clinical Endocrinology & Metabolism, Volume 92, Issue 7, 1 July 2007, Pages 2453–2461, https://doi.org/10.1210/jc.2007-0282
Close

Navbar Search Filter Mobile Enter search term Search

Abstract

Context: Oral contraceptives may worsen the metabolic profile of patients with polycystic ovary syndrome (PCOS), favoring the use of insulin sensitizers in these patients.

Objective: The aim of the study was to compare the effects of a contraceptive pill on metabolic classic cardiovascular risk factors with those of the insulin sensitizer metformin.

Design: We conducted a randomized, parallel, open-label clinical trial.

Setting: The study was conducted at an academic hospital.

Patients: Thirty-four consecutive PCOS patients were studied.

Interventions: Patients were randomized to oral treatment with metformin (850 mg twice daily) or with the Diane35 Diario pill (35 μg of ethinyl-estradiol plus 2 mg of cyproterone acetate) for 24 wk.

Main Outcome Measures: Hyperandrogenism, lipid profiles, and indexes of glucose tolerance and insulin sensitivity were measured at baseline and after 12 and 24 wk of treatment.

Results: Diane35 Diario resulted in higher reductions in hirsutism score and serum androgen levels compared with metformin. Menstrual regularity was restored in all the patients treated with Diane35 Diario compared with only 50% of those receiving metformin. Plasma apolipoprotein A-I and HDL-phospholipid levels increased with Diane35 Diario, whereas metformin did not induce any change in the lipid profile. On the contrary, the insulin sensitivity index increased with metformin but did not change with Diane35 Diario. No differences in the frequencies of abnormalities of glucose tolerance and dyslipidemia were found between both treatments.

Conclusions: Diane35 Diario appears to be superior to metformin for the control of hyperandrogenism and for the restoration of menstrual regularity in PCOS patients, and it is not associated with any clinically relevant worsening in the classic metabolic cardiovascular risk profile of these women.

Copyright © 2007 by The Endocrine Society

You do not currently have access to this article.

Personal account

• Sign in with email/username & password
• Get email alerts
• Save searches
• Purchase content
• Activate your purchase/trial code
• Add your ORCID iD

Get help with access

Institutional access

Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:

IP based access

Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.

Sign in through your institution

Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.

1. Click Sign in through your institution.
2. Select your institution from the list provided, which will take you to your institution's website to sign in.
3. When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
4. Following successful sign in, you will be returned to Oxford Academic.

If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.

Sign in with a library card

Enter your library card number to sign in. If you cannot sign in, please contact your librarian.

Society Members

Society member access to a journal is achieved in one of the following ways:

Sign in through society site

Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:

1. Click Sign in through society site.
2. When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
3. Following successful sign in, you will be returned to Oxford Academic.

If you do not have a society account or have forgotten your username or password, please contact your society.

Sign in using a personal account

Some societies use Oxford Academic personal accounts to provide access to their members. See below.

Personal account

A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.

Some societies use Oxford Academic personal accounts to provide access to their members.

Viewing your signed in accounts

Click the account icon in the top right to:

• View your signed in personal account and access account management features.
• View the institutional accounts that are providing access.

Signed in but can't access content

Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.

Institutional account management

For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.

Purchase

Short-term Access

To purchase short-term access, please sign in to your personal account above.

Don't already have a personal account? Register

Comparison of Ethinyl-Estradiol Plus Cyproterone Acetate Versus Metformin Effects on Classic Metabolic Cardiovascular Risk Factors in Women with the Polycystic Ovary Syndrome - 24 Hours access

EUR €38.00

GBP £33.00

USD $41.00

Rental

This article is also available for rental through DeepDyve.

Citations

Views

Altmetric

Metrics

Total Views 2,148

1,486 Pageviews

662 PDF Downloads

Since 1/1/2017

Citations

81 Web of Science

×

Email alerts

More on this topic

Related articles in PubMed

Citing articles via

• Latest

• Most Read

• Most Cited

More from Oxford Academic