Islet Number Rather Than Islet Size Is a Major Determinant of β- and α-Cell Mass in Humans (original) (raw)
Journal Article
1Departments of Internal Medicine (K.K., Y.S., S.S., H.I.), Keio University School of Medicine, Tokyo 160-8582, Japan
Search for other works by this author on:
1Departments of Internal Medicine (K.K., Y.S., S.S., H.I.), Keio University School of Medicine, Tokyo 160-8582, Japan
*Address all correspondence and requests for reprints to: Yoshifumi Saisho, MD, PhD, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Search for other works by this author on:
1Departments of Internal Medicine (K.K., Y.S., S.S., H.I.), Keio University School of Medicine, Tokyo 160-8582, Japan
Search for other works by this author on:
2Pathology (T.Y.), Keio University School of Medicine, Tokyo 160-8582, Japan
Search for other works by this author on:
1Departments of Internal Medicine (K.K., Y.S., S.S., H.I.), Keio University School of Medicine, Tokyo 160-8582, Japan
Search for other works by this author on:
Received:
09 October 2013
Accepted:
28 January 2014
Cite
Kinsei Kou, Yoshifumi Saisho, Seiji Sato, Taketo Yamada, Hiroshi Itoh, Islet Number Rather Than Islet Size Is a Major Determinant of β- and α-Cell Mass in Humans, The Journal of Clinical Endocrinology & Metabolism, Volume 99, Issue 5, 1 May 2014, Pages 1733–1740, https://doi.org/10.1210/jc.2013-3731
Close
Navbar Search Filter Mobile Enter search term Search
Objective:
The objective of the study was to clarify the relative contribution of islet number and islet size to β- and α-cell mass in humans.
Research Design and Methods:
We obtained the pancreas at autopsy from 72 Japanese adults with no history of diabetes or pancreatitis (aged 47 ± 12 years, body mass index 24.1 ± 5.0 kg/m2). Pancreatic sections were stained for insulin or glucagon, and fractional β-cell area (%BCA) and α-cell area (%ACA) were measured. Islet number and islet size as well as β-cell turnover were also quantified. Glycosylated hemoglobin measured within 1 year prior to death was obtained in 38 individuals.
Results:
There was considerable interindividual variation in islet density and mean islet size, with a significant negative correlation between the two (r = −0.25, P = .03). There were significant positive correlations between islet density and %BCA or %ACA (r = 0.63, P < .001, and r = 0.41, P = .001), whereas mean islet size correlated with neither of them. Islet density as well as %BCA, but not mean islet size, was negatively correlated with glycosylated hemoglobin (r = −0.37, P = .02, and r = −0.36, P = .03).
Conclusion:
The present study suggests that islet number rather than islet size is a major determinant of β- and α-cell mass in humans. Interindividual difference in islet number may contribute to susceptibility to development of glucose intolerance.
Copyright © 2014 by the Endocrine Society
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution's website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution's website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see "Sign in through society site" in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Islet Number Rather Than Islet Size Is a Major Determinant of β- and α-Cell Mass in Humans - 24 Hours access
EUR €39.00
GBP £33.00
USD $43.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Email alerts
Related articles in PubMed
Citing articles via
More from Oxford Academic