Immunoreactive Human Epidermal Growth Factor in Human Pancreatic Juice* (original) (raw)
Journal Article
,
1Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, and the Division of Clinical Nutrition, Kyoto University Faculty of Medicine Kyoto 606, Japan; Department of Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan
Search for other works by this author on:
,
1Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, and the Division of Clinical Nutrition, Kyoto University Faculty of Medicine Kyoto 606, Japan; Department of Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan
Search for other works by this author on:
,
1Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, and the Division of Clinical Nutrition, Kyoto University Faculty of Medicine Kyoto 606, Japan; Department of Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan
Search for other works by this author on:
,
1Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, and the Division of Clinical Nutrition, Kyoto University Faculty of Medicine Kyoto 606, Japan; Department of Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan
Search for other works by this author on:
1Third Division, Department of Medicine, Kobe University School of Medicine, Kobe 650, and the Division of Clinical Nutrition, Kyoto University Faculty of Medicine Kyoto 606, Japan; Department of Medicine, Kyoto University Faculty of Medicine Kyoto 606, Japan
Search for other works by this author on:
Received:
15 October 1981
Cite
YUKIO HIRATA, MASAHITO UCHIHASHI, MASAKO NAKAJIMA, TAKUO FUJITA, SHIGERU MATSUKURA, Immunoreactive Human Epidermal Growth Factor in Human Pancreatic Juice, The Journal of Clinical Endocrinology & Metabolism, Volume 54, Issue 6, 1 June 1982, Pages 1242–1245, https://doi.org/10.1210/jcem-54-6-1242
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Human epidermal growth factor (hEGF), whichstimulates the growth of a variety of cells in culture, has recentlybeen isolated from human urine. In the present study, we identifiedsignificant amounts of immunoreactive (IR) hEGF (mean± SE, 2.3 ±0.09 ng/ml; n = 3) in human pancreatic juice. TheIR-hEGF materials were immunologically indistinguishablefrom standard hEGF, although they were only 5% as active inreceptor binding to human placental membrane as in RIA. Gelexclusion chromatography of the pancreatic juice under neutraland acidic conditions revealed three distinct IR-hEGF componentswith different molecular sizes. Incubation of l25I-labeledhEGF with either the pancreatic juice or the high molecularweight component(s) yielded no aggregationor degradationproducts. These data suggest that fully immunoreactive butmuch less bioactive hEGF-like substances which are heterogeneousin size are secreted into human pancreatic juice. Theirtissue (s) of origin and physiological functions, if any, remain tobe elucidated. (J Clin Endocrinol Metab54: 1242, 1982)
This content is only available as a PDF.
Copyright © 1982 by The Endocrine Society
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Immunoreactive Human Epidermal Growth Factor in Human Pancreatic Juice* - 24 Hours access
EUR €38.00
GBP £33.00
USD $41.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Metrics
Total Views 7
0 Pageviews
7 PDF Downloads
Since 9/1/2017
| Month: | Total Views: |
|---|---|
| September 2017 | 1 |
| March 2022 | 2 |
| May 2022 | 1 |
| July 2022 | 1 |
| June 2023 | 1 |
| October 2023 | 1 |
Citations
58 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic