IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY (original) (raw)

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SASAKI ATSUSHI ,

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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S. LIOTTA ANTHONY ,

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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M. LUCKEY MARJORIE ,

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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N. MARGIORIS ANDREW ,

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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SUDA TOSHIHIRO ,

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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T.KRIEGER DOROTHY

1Division of Endocrinology, Department of Medicine Mount Sinai Medical Center, New York, New York 10029; Department of Obstetrics and Gynecology Mount Sinai Medical Center, New York, New York 10029; Department of Medicine Tokyo Women's Medical College, Tokyo 162, Japan

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Published:

01 October 1984

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SASAKI ATSUSHI, S. LIOTTA ANTHONY, M. LUCKEY MARJORIE, N. MARGIORIS ANDREW, SUDA TOSHIHIRO, T.KRIEGER DOROTHY, IMMUNOREACTIVE CORTICOTROPIN-RELEASING FACTOR IS PRESENT IN HUMAN MATERNAL PLASMA DURING THE THIRD TRIMESTER OF PREGNANCY, The Journal of Clinical Endocrinology & Metabolism, Volume 59, Issue 4, 1 October 1984, Pages 812–814, https://doi.org/10.1210/jcem-59-4-812
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Abstract

Immunoreactive (IR) corticotropin-releasing factor (CRF)-like activity was detectable in the majority of plasma samples obtained from women in the third trimester of pregnancy (68.7 ± 23.6 pg/ml(14.4 ± 4.9 fmol/ml); mean ± SE, n=15), but not in plasma (<10 pg/ml) from first (n=9) or second (n=ll) trimester of pregnancy, 1 day post partum (n=7), non-pregnant women (n=10), or in plasma obtained from patients with Cushing's disease (n=2) or Nelson's syndrome (n=l), or in basal (n=6) or ether-stressed (n=6) rat plasma. Gel filtration of third trimester pooled plasma revealed that the majority of such material eluted with Kav of rat CRF(1–41). The IR CRF(1–41)-sized material eluted with the identical retention time as rat CRF in a reverse phase high performance liquid chromatography (HPLC) system. The detection of IR CRF exclusively in third trimester maternal plasma, together with our previous demonstration that material physicochemically indistinguishable from it is present in human term placental extracts, suggests that the placenta may be the source of plasma IR CRF.

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Copyright © 1984 by The Endocrine Society

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