Elevated Production Rate of 1,25-Dihydroxyvitamin D in Patients with Absorptive Hypercalciuria* (original) (raw)
Journal Article
,
1Departments of Medicine and Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510
Search for other works by this author on:
,
1Departments of Medicine and Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510
Search for other works by this author on:
,
1Departments of Medicine and Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510
Search for other works by this author on:
,
1Departments of Medicine and Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510
Search for other works by this author on:
1Departments of Medicine and Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510
Search for other works by this author on:
Published:
01 September 1985
Cite
KARL L. INSOGNA, ARTHUR E. BROADUS, BARBARA E. DREYER, ALICE F. ELLISON, JOSEPH M. GERTNER, Elevated Production Rate of 1,25-Dihydroxyvitamin D in Patients with Absorptive Hypercalciuria, The Journal of Clinical Endocrinology & Metabolism, Volume 61, Issue 3, 1 September 1985, Pages 490–495, https://doi.org/10.1210/jcem-61-3-490
Close
Navbar Search Filter Mobile Enter search term Search
Abstract
Previous studies of 1,25-dihydroxyvitamin D [1,25-(OH)2D] kinetics in normal subjects using the pulse injection technique have led to conflicting results, and only limited data are available concerning 1,25-(OH)2D kinetics in hypercalciuric patients. We developed an infusion equilibrium technique that measures the metabolic clearance and production rates of 1,25-(OH)2D and applied this technique in 13 normal subjects and 9 well characterized patients with absorptive hypercalciuria; all subjects were studied after 10 days on a 400-mg calcium intake. All subjects received a constant infusion of [3H]1,25-(OH)2D3 (20,000 dpm/min). Purified plasma radioactivity reached steady state levels after 15 h, and between 15 and 19 h, serial measurements of purified plasma radioactivity and endogenous 1,25-(OH)2D were made for calculation of metabolic clearance and production rates.
In the 13 normal subjects, the MCR values were within a narrow range, with a mean ± SD value of 37 ± 6 ml/min, which, when combined with the mean steady state concentration of endogenous 1,25-(OH)2D (42 ± 6 pg/ml), yielded a mean production rate of 2.2 ± 0.5 μg/day. In the 9 patients with absorptive hypercalciuria, MCR values also were tightly clustered, with a mean of 35 ± 4 ml/min. However, the mean endogenous steady state 1,25-(OH)2D level was significantly elevated in these patients, such that the calculated mean 1,25-(OH)2D production rate was significantly elevated at 3.4 ± 0.5 μg/day. In 7 of the 9 patients with absorptive hypercalciuria, production rates exceeded the highest values found in the normal subjects. These data demonstrate disordered 1,25-(OH)2D production as opposed to metabolic clearance in the syndrome of absorptive hypercalciuria.
This content is only available as a PDF.
Copyright © 1985 by The Endocrine Society
You do not currently have access to this article.
Personal account
- Sign in with email/username & password
- Get email alerts
- Save searches
- Purchase content
- Activate your purchase/trial code
- Add your ORCID iD
Get help with access
Institutional access
Access to content on Oxford Academic is often provided through institutional subscriptions and purchases. If you are a member of an institution with an active account, you may be able to access content in one of the following ways:
IP based access
Typically, access is provided across an institutional network to a range of IP addresses. This authentication occurs automatically, and it is not possible to sign out of an IP authenticated account.
Sign in through your institution
Choose this option to get remote access when outside your institution. Shibboleth/Open Athens technology is used to provide single sign-on between your institution’s website and Oxford Academic.
- Click Sign in through your institution.
- Select your institution from the list provided, which will take you to your institution's website to sign in.
- When on the institution site, please use the credentials provided by your institution. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If your institution is not listed or you cannot sign in to your institution’s website, please contact your librarian or administrator.
Sign in with a library card
Enter your library card number to sign in. If you cannot sign in, please contact your librarian.
Society Members
Society member access to a journal is achieved in one of the following ways:
Sign in through society site
Many societies offer single sign-on between the society website and Oxford Academic. If you see ‘Sign in through society site’ in the sign in pane within a journal:
- Click Sign in through society site.
- When on the society site, please use the credentials provided by that society. Do not use an Oxford Academic personal account.
- Following successful sign in, you will be returned to Oxford Academic.
If you do not have a society account or have forgotten your username or password, please contact your society.
Sign in using a personal account
Some societies use Oxford Academic personal accounts to provide access to their members. See below.
Personal account
A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions.
Some societies use Oxford Academic personal accounts to provide access to their members.
Viewing your signed in accounts
Click the account icon in the top right to:
- View your signed in personal account and access account management features.
- View the institutional accounts that are providing access.
Signed in but can't access content
Oxford Academic is home to a wide variety of products. The institutional subscription may not cover the content that you are trying to access. If you believe you should have access to that content, please contact your librarian.
Institutional account management
For librarians and administrators, your personal account also provides access to institutional account management. Here you will find options to view and activate subscriptions, manage institutional settings and access options, access usage statistics, and more.
Purchase
Short-term Access
To purchase short-term access, please sign in to your personal account above.
Don't already have a personal account? Register
Elevated Production Rate of 1,25-Dihydroxyvitamin D in Patients with Absorptive Hypercalciuria* - 24 Hours access
EUR €38.00
GBP £33.00
USD $41.00
Rental
This article is also available for rental through DeepDyve.
Citations
Views
Altmetric
Metrics
Total Views 16
2 Pageviews
14 PDF Downloads
Since 9/1/2017
| Month: | Total Views: |
|---|---|
| September 2017 | 1 |
| October 2017 | 1 |
| November 2017 | 1 |
| April 2018 | 2 |
| February 2019 | 1 |
| May 2019 | 1 |
| June 2019 | 1 |
| December 2019 | 1 |
| January 2020 | 1 |
| February 2020 | 1 |
| April 2020 | 1 |
| October 2020 | 1 |
| March 2023 | 1 |
| September 2023 | 1 |
| December 2023 | 1 |
Citations
88 Web of Science
×
Email alerts
Citing articles via
More from Oxford Academic