Serum Concentrations of Alkaline Phosphatase Isoenzymes and Osteocalcin in Normal Pregnancy* (original) (raw)
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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1Departments of Obstetrics (A.R., A.D., H.W.P.Q., G.P., M.G.C.) and Nuclear Medicine (G.M., I.F.), Guy's Hospital; Cavendish Clinic (D.C., J.C.S.) London, England; The Department of Chemical Pathology, Hammersmith Hospital (K.W.) London, England
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Cite
A. RODIN, A. DUNCAN, H. W. P. QUARTERO, G. PISTOFIDIS, G. MASHITER, K. WHITAKER, D. CROOK, J. C. STEVENSON, M. G. CHAPMAN, I. FOGELMAN, Serum Concentrations of Alkaline Phosphatase Isoenzymes and Osteocalcin in Normal Pregnancy, The Journal of Clinical Endocrinology & Metabolism, Volume 68, Issue 6, 1 June 1989, Pages 1123–1127, https://doi.org/10.1210/jcem-68-6-1123
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Abstract
We measured serum alkaline phosphatase isoenzymes and osteocalcin levels in 40 healthy women at 4-week intervals throughout uncomplicated pregnancies and 6 weeks after delivery in 17 women. Serum bone alkaline phosphatase was significantly higher in the third trimester than in early pregnancy (P < 0.001), and this elevation was still apparent at the end of the puerperium, suggesting increased bone turnover. Serum osteocalcin was not detected (<0.2 _μ_g/L) after the first trimester in the majority of women, and it reappeared within 48 h after delivery. The disappearance of osteocalcin after the first trimester and its rapid reappearance after delivery suggest placental clearance of this peptide. We conclude that serum osteocalcin measurements cannot be used as a marker of bone metabolism during pregnancy.
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Copyright © 1989 by The Endocrine Society
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